New optical techniques shed light on protein aggregation

FunGen-AD grantee Peter St George-Hyslop was part of a collaboration among researchers from the University of Sydney, University of Cambridge, Harvard University, and Columbia University that developed new optical methods to observe development of pathological protein aggregates in cells.

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New biomarker of early-stage Alzheimer’s disease identified in study supported by FunGen-AD

FunGen-AD investigator Carlos Cruchaga was part of a team that identified a unique biomarker that could lead to new diagnostic tests able to detect Alzheimer’s disease before symptoms appear. Levels of this protein in cerebrospinal fluid can reliably detect damage to the cells lining tiny blood vessels in the brain in Alzheimer’s disease. Blood vessel injury is an important contributor to cognitive impairment in even the earliest presymptomatic stages of the disease.

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