Publications

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    2023

  1. Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways

    Webber, CJ; Murphy, CN; Rondón-Ortiz, AN; van der Spek, SJF; Kelly, EX; Lampl, NM; Chiesa, G; Khalil, AS; Emili, A; Wolozin, B;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 20;  
    DOI: 10.1093/hmg/ddad122

  2. Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk

    Celis, K; Moreno, MDMM; Rajabli, F; Whitehead, P; Hamilton-Nelson, K; Dykxhoorn, DM; Nuytemans, K; Wang, L; Flanagan, M; Weintraub, S; Geula, C; Gearing, M; Dalgard, CL; Jin, F; Bennett, DA; Schuck, T; Pericak-Vance, MA; Griswold, AJ; Young, JI; Vance, JM;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 9;  
    DOI: 10.1002/alz.13075

  3. Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions

    Park, J; Wu, Y; Shao, W; Gendron, TF; van der Spek, SJF; Sultanakhmetov, G; Basu, A; Castellanos Otero, P; Jones, CJ; Jansen-West, K; Daughrity, LM; Phanse, S; Del Rosso, G; Tong, J; Castanedes-Casey, M; Jiang, L; Libera, J; Oskarsson, B; Dickson, DW; Sanders, DW; Brangwynne, CP; Emili, A; Wolozin, B; Petrucelli, L; Zhang, Y;
    2023;  
    Cell Reports;  
    Volume: 42;  
    Issue: 8;  
    DOI: 10.1016/j.celrep.2023.112822

  4. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1

    Lee, H; Aylward, AJ; Pearse, RV; Lish, AM; Hsieh, Y; Augur, ZM; Benoit, CR; Chou, V; Knupp, A; Pan, C; Goberdhan, S; Duong, DM; Seyfried, NT; Bennett, DA; Taga, MF; Huynh, K; Arnold, M; Meikle, PJ; De Jager, PL; Menon, V; Young, JE; Young-Pearse, TL;
    2023;  
    Cell Reports;  
    Volume: 42;  
    Issue: 8;  
    DOI: 10.1016/j.celrep.2023.112994

  5. Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature

    Berson, E; Sreenivas, A; Phongpreecha, T; Perna, A; Grandi, FC; Xue, L; Ravindra, NG; Payrovnaziri, N; Mataraso, S; Kim, Y; Espinosa, C; Chang, AL; Becker, M; Montine, KS; Fox, EJ; Chang, HY; Corces, MR; Aghaeepour, N; Montine, TJ;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1038/s41467-023-40611-4

  6. The liquid-to-solid transition of FUS is promoted by the condensate surface

    Shen, Y; Chen, A; Wang, W; Shen, Y; Ruggeri, FS; Aime, S; Wang, Z; Qamar, S; Espinosa, JR; Garaizar, A; St George-Hyslop, P; Collepardo-Guevara, R; Weitz, DA; Vigolo, D; Knowles, TPJ;
    2023;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 120;  
    Issue: 33;  
    DOI: 10.1073/pnas.2301366120

  7. Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease

    Robison, LS; Gannon, OJ; Salinero, AE; Abi-Ghanem, C; Kelly, RD; Riccio, DA; Mansour, FM; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13293-023-00536-5

  8. An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology

    Sheehan, PW; Nadarajah, CJ; Kanan, MF; Patterson, JN; Novotny, B; Lawrence, JH; King, MW; Brase, L; Inman, CE; Yuede, CM; Lee, J; Patel, TK; Harari, O; Benitez, BA; Davis, AA; Musiek, ES;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 15;  
    DOI: 10.1016/j.neuron.2023.05.006

  9. Genetic architecture of plasma Alzheimer disease biomarkers

    Bradley, J; Gorijala, P; Schindler, SE; Sung, YJ; Ances, B; Alzheimer’s Disease Neuroimaging Initiative, the Human Connectome Project; Fernandez, MV; Cruchaga, C;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 15;  
    DOI: 10.1093/hmg/ddad087

  10. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease

    Phillips, B; Western, D; Wang, L; Timsina, J; Sun, Y; Gorijala, P; Yang, C; Do, A; Nykänen, N; Alvarez, I; Aguilar, M; Pastor, P; Morris, JC; Schindler, SE; Fagan, AM; Puerta, R; García-González, P; de Rojas, I; Marquié, M; Boada, M; Ruiz, A; Perlmutter, JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez, L; Perrin, RJ; Sung, YJ; Cruchaga, C;
    2023;  
    NPJ Parkinson's disease;  
    Volume: 9;  
    Issue: 1;  
    DOI: 10.1038/s41531-023-00555-4

  11. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease

    Sung, YJ; Yang, C; Norton, J; Johnson, M; Fagan, A; Bateman, RJ; Perrin, RJ; Morris, JC; Farlow, MR; Chhatwal, JP; Schofield, PR; Chui, H; Wang, F; Novotny, B; Eteleeb, A; Karch, C; Schindler, SE; Rhinn, H; Johnson, ECB; Oh, HS; Rutledge, JE; Dammer, EB; Seyfried, NT; Wyss-Coray, T; Harari, O; Cruchaga, C;
    2023;  
    Science Translational Medicine;  
    Volume: 15;  
    Issue: 703;  
    DOI: 10.1126/scitranslmed.abq5923

  12. Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy

    Zhao, J; Jiang, L; Matlock, A; Xu, Y; Zhu, J; Zhu, H; Tian, L; Wolozin, B; Cheng, J;
    2023;  
    Light, Science & Applications;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1038/s41377-023-01191-6

  13. Autolysosomal exocytosis of lipids protect neurons from ferroptosis

    Ralhan, I; Chang, J; Moulton, MJ; Goodman, LD; Lee, NYJ; Plummer, G; Pasolli, HA; Matthies, D; Bellen, HJ; Ioannou, MS;
    2023;  
    The Journal of Cell Biology;  
    Volume: 222;  
    Issue: 6;  
    DOI: 10.1083/jcb.202207130

  14. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease

    Young-Pearse, TL; Lee, H; Hsieh, Y; Chou, V; Selkoe, DJ;
    2023;  
    Trends in Neurosciences;  
    Volume: 46;  
    Issue: 6;  
    DOI: 10.1016/j.tins.2023.03.005

  15. APOE and immunity: Research highlights

    Kloske, CM; Barnum, CJ; Batista, AF; Bradshaw, EM; Brickman, AM; Bu, G; Dennison, J; Gearon, MD; Goate, AM; Haass, C; Heneka, MT; Hu, WT; Huggins, LKL; Jones, NS; Koldamova, R; Lemere, CA; Liddelow, SA; Marcora, E; Marsh, SE; Nielsen, HM; Petersen, KK; Petersen, M; Piña-Escudero, SD; Qiu, WQ; Quiroz, YT; Reiman, E; Sexton, C; Tansey, MG; Tcw, J; Teunissen, CE; Tijms, BM; van der Kant, R; Wallings, R; Weninger, SC; Wharton, W; Wilcock, DM; Wishard, TJ; Worley, SL; Zetterberg, H; Carrillo, MC;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 6;  
    DOI: 10.1002/alz.13020

  16. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

    Filipello, F; You, S; Mirfakhar, FS; Mahali, S; Bollman, B; Acquarone, M; Korvatska, O; Marsh, JA; Sivaraman, A; Martinez, R; Cantoni, C; De Feo, L; Ghezzi, L; Minaya, MA; Renganathan, A; Cashikar, AG; Satoh, J; Beatty, W; Iyer, AK; Cella, M; Raskind, WH; Piccio, L; Karch, CM;
    2023;  
    Acta Neuropathologica;  
    Volume: 145;  
    Issue: 6;  
    DOI: 10.1007/s00401-023-02568-y

  17. Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia

    Gannon, OJ; Naik, JS; Riccio, D; Mansour, FM; Abi-Ghanem, C; Salinero, AE; Kelly, RD; Brooks, HL; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13293-023-00518-7

  18. Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease

    Panyard, DJ; McKetney, J; Deming, YK; Morrow, AR; Ennis, GE; Jonaitis, EM; Van Hulle, CA; Yang, C; Sung, YJ; Ali, M; Kollmorgen, G; Suridjan, I; Bayfield, A; Bendlin, BB; Zetterberg, H; Blennow, K; Cruchaga, C; Carlsson, CM; Johnson, SC; Asthana, S; Coon, JJ; Engelman, CD;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    DOI: 10.1002/alz.13130

  19. Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID

    Abi-Ghanem, C; Salinero, AE; Kordit, D; Mansour, FM; Kelly, RD; Venkataganesh, H; Kyaw, N; Gannon, OJ; Riccio, D; Fredman, G; Poitelon, Y; Belin, S; Kopec, AM; Robison, LS; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13293-023-00513-y

  20. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease

    Bourquard, T; Lee, K; Al-Ramahi, I; Pham, M; Shapiro, D; Lagisetty, Y; Soleimani, S; Mota, S; Wilhelm, K; Samieinasab, M; Kim, YW; Huh, E; Asmussen, J; Katsonis, P; Botas, J; Lichtarge, O;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1038/s41467-023-38374-z

  21. Advancing cell therapy for neurodegenerative diseases

    Temple, S;
    2023;  
    Cell Stem Cell;  
    Volume: 30;  
    Issue: 5;  
    DOI: 10.1016/j.stem.2023.03.017

  22. A global view of the genetic basis of Alzheimer disease

    Reitz, C; Pericak-Vance, MA; Foroud, T; Mayeux, R;
    2023;  
    Nature Reviews. Neurology;  
    Volume: 19;  
    Issue: 5;  
    DOI: 10.1038/s41582-023-00789-z

  23. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

    Qiao, M; Lee, AJ; Reyes-Dumeyer, D; Tosto, G; Faber, K; Goate, A; Renton, A; Chao, M; Boeve, B; Cruchaga, C; Pericak-Vance, M; Haines, JL; Rosenberg, R; Tsuang, D; Sweet, RA; Bennett, DA; Wilson, RS; Foroud, T; Mayeux, R; Vardarajan, BN;
    2023;  
    Annals of Clinical and Translational Neurology;  
    Volume: 10;  
    Issue: 5;  
    DOI: 10.1002/acn3.51757

  24. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease

    Huang, J; Stein, TD; Wang, Y; Ang, TFA; Tao, Q; Lunetta, KL; Massaro, J; Akhter-Khan, SC; Mez, J; Au, R; Farrer, LA; Zhang, X; Qiu, WQ; Alzheimer's Disease Neuroimaging Initiative;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 5;  
    DOI: 10.1002/alz.12851

  25. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

    Ali, M; Archer, DB; Gorijala, P; Western, D; Timsina, J; Fernández, MV; Wang, T; Satizabal, CL; Yang, Q; Beiser, AS; Wang, R; Chen, G; Gordon, B; Benzinger, TLS; Xiong, C; Morris, JC; Bateman, RJ; Karch, CM; McDade, E; Goate, A; Seshadri, S; Mayeux, RP; Sperling, RA; Buckley, RF; Johnson, KA; Won, H; Jung, S; Kim, H; Seo, SW; Kim, HJ; Mormino, E; Laws, SM; Fan, K; Kamboh, MI; Vemuri, P; Ramanan, VK; Yang, H; Wenzel, A; Rajula, HSR; Mishra, A; Dufouil, C; Debette, S; Lopez, OL; DeKosky, ST; Tao, F; Nagle, MW; Knight Alzheimer Disease Research Center (Knight ADRC); Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); ADNI-DOD, A4 Study Team; Australian Imaging Biomarkers, Lifestyle (AIBL) Study; Hohman, TJ; Sung, YJ; Dumitrescu, L; Cruchaga, C;
    2023;  
    Acta Neuropathologica Communications;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1186/s40478-023-01563-4

  26. Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer's and coronary disease pathways

    Wang, L; Western, D; Timsina, J; Repaci, C; Song, W; Norton, J; Kohlfeld, P; Budde, J; Climer, S; Butt, OH; Jacobson, D; Garvin, M; Templeton, AR; Campagna, S; O'Halloran, J; Presti, R; Goss, CW; Mudd, PA; Ances, BM; Zhang, B; Sung, YJ; Cruchaga, C;
    2023;  
    iScience;  
    Volume: 26;  
    Issue: 4;  
    DOI: 10.1016/j.isci.2023.106408

  27. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

    Brase, L; You, S; D'Oliveira Albanus, R; Del-Aguila, JL; Dai, Y; Novotny, BC; Soriano-Tarraga, C; Dykstra, T; Fernandez, MV; Budde, JP; Bergmann, K; Morris, JC; Bateman, RJ; Perrin, RJ; McDade, E; Xiong, C; Goate, AM; Farlow, M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland, GT; Kipnis, J; Karch, CM; Benitez, BA; Harari, O;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1038/s41467-023-37437-5

  28. Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity

    Honig, LS; Kang, MS; Lee, AJ; Reyes-Dumeyer, D; Piriz, A; Soriano, B; Franco, Y; Coronado, ZD; Recio, P; Mejía, DR; Medrano, M; Lantigua, RA; Teich, AF; Dage, JL; Mayeux, R;
    2023;  
    JAMA network open;  
    Volume: 6;  
    Issue: 4;  
    DOI: 10.1001/jamanetworkopen.2023.8214

  29. The role of innate lymphocytes in regulating brain and cognitive function

    Si, Y; Zhang, Y; Zuloaga, K; Yang, Q;
    2023;  
    Neurobiology of Disease;  
    Volume: 179;  
    DOI: 10.1016/j.nbd.2023.106061

  30. The complex genetic architecture of Alzheimer's disease: novel insights and future directions

    Andrews, SJ; Renton, AE; Fulton-Howard, B; Podlesny-Drabiniok, A; Marcora, E; Goate, AM;
    2023;  
    EBioMedicine;  
    Volume: 90;  
    DOI: 10.1016/j.ebiom.2023.104511

  31. Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

    Pettigrew, C; Nazarovs, J; Soldan, A; Singh, V; Wang, J; Hohman, T; Dumitrescu, L; Libby, J; Kunkle, B; Gross, AL; Johnson, S; Lu, Q; Engelman, C; Masters, CL; Maruff, P; Laws, SM; Morris, JC; Hassenstab, J; Cruchaga, C; Resnick, SM; Kitner-Triolo, MH; An, Y; Albert, M;
    2023;  
    Alzheimer's Research & Therapy;  
    Volume: 15;  
    Issue: 1;  
    DOI: 10.1186/s13195-023-01206-9

  32. Evolutionarily conserved regulators of tau identify targets for new therapies

    Kim, J; de Haro, M; Al-Ramahi, I; Garaicoechea, LL; Jeong, H; Sonn, JY; Tadros, B; Liu, Z; Botas, J; Zoghbi, HY;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 6;  
    DOI: 10.1016/j.neuron.2022.12.012

  33. The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

    Maestre, G; Carrillo, M; Kalaria, R; Acosta, D; Adams, L; Adoukonou, T; Akinwande, K; Akinyemi, J; Akinyemi, R; Akpa, O; Alladi, S; Allegri, R; Arizaga, R; Arshad, F; Arulogun, O; Babalola, D; Baiyewu, O; Bak, T; Bellaj, T; Boshe, J; Brayne, C; Brodie-Mends, D; Brown, R; Cahn, J; Cyrille, N; Damasceno, A; de Silva, R; de Silva, R; Djibuti, M; Dreyer, AJ; Ellajosyula, R; Farombi, T; Fongang, B; Forner, S; Friedland, R; Garza, N; Gbessemehlan, A; Georgiou, EE; Gouider, R; Govia, I; Grinberg, L; Guerchet, M; Gugssa, S; Gumikiriza-Onoria, JL; Gustafson, D; Hogervorst, E; Hornberger, M; Ibanez, A; Ihara, M; Ismail, O; Issac, T; Jönsson, L; Kaputu, C; Karanja, W; Karungi, J; Tshala-Katumbay, D; Kunkle, B; Lee, JH; Leroi, I; Lewis, R; Livingston, G; Lopera, F; Lwere, K; Manes, F; Mbakile-Mahlanza, L; Mena, P; Miller, B; Millogo, A; Mohamed, A; Musyimi, C; Mutiso, V; Nakasujja, N; Ndetei, D; Nightingale, S; Njamnshi, AK; Novotni, G; Nyamayaro, P; Nyame, S; Ogeng'o, J; Ogunniyi, A; Okada De Oliveira, M; Okubadejo, N; Orrell, M; Orunmuyi, A; Owolabi, M; Paddick, S; A Pericak-Vance, M; Pirtosek, Z; Potocnik, F; Preston, B; Raman, R; Ranchod, K; Rizig, M; Rosselli, M; Deepa, R; Roy, U; Salokhiddinov, M; Sano, M; Sarfo, F; Satizabal, CL; Sepulveda-Falla, D; Seshadri, S; Sexton, C; Skoog, I; St George-Hyslop, P; Suemoto, C; Tanner, J; Thapa, P; Toure, K; Ucheagwu, V; Udeh-Momoh, C; Valcour, V; Vance, J; Varghese, M; Vera, J; Walker, R; Weidner, W; Sebastian, W; Whitehead Gay, P; Zetterberg, H; Zewde, Y; African Dementia Consortium;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    DOI: 10.1002/alz.13025

  34. Identification of circRNAs linked to Alzheimer's disease and related dementias

    Puri, S; Hu, J; Sun, Z; Lin, M; Stein, TD; Farrer, LA; Wolozin, B; Zhang, X;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    DOI: 10.1002/alz.12960

  35. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

    Jiang, L; Chakraborty, P; Zhang, L; Wong, M; Hill, SE; Webber, CJ; Libera, J; Blair, LJ; Wolozin, B; Zweckstetter, M;
    2023;  
    Science Advances;  
    Volume: 9;  
    Issue: 5;  
    DOI: 10.1126/sciadv.add9789

  36. Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes

    Li, J; Amoh, BK; McCormick, E; Tarkunde, A; Zhu, KF; Perez, A; Mair, M; Moore, J; Shulman, JM; Al-Ramahi, I; Botas, J;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 4;  
    DOI: 10.1093/hmg/ddac230

  37. Genetics and Pathogenesis of Parkinson's Syndrome

    Ye, H; Robak, LA; Yu, M; Cykowski, M; Shulman, JM;
    2023;  
    Annual Review of Pathology;  
    Volume: 18;  
    DOI: 10.1146/annurev-pathmechdis-031521-034145

  38. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

    Gratuze, M; Schlachetzki, JCM; D'Oliveira Albanus, R; Jain, N; Novotny, B; Brase, L; Rodriguez, L; Mansel, C; Kipnis, M; O'Brien, S; Pasillas, MP; Lee, C; Manis, M; Colonna, M; Harari, O; Glass, CK; Ulrich, JD; Holtzman, DM;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 2;  
    DOI: 10.1016/j.neuron.2022.10.022

  39. Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

    Minaya, MA; Mahali, S; Iyer, AK; Eteleeb, AM; Martinez, R; Huang, G; Budde, J; Temple, S; Nana, AL; Seeley, WW; Spina, S; Grinberg, LT; Harari, O; Karch, CM;
    2023;  
    Frontiers in Molecular Biosciences;  
    Volume: 10;  
    DOI: 10.3389/fmolb.2023.1051494

  40. The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms

    Felsky, D; Santa-Maria, I; Cosacak, MI; French, L; Schneider, JA; Bennett, DA; De Jager, PL; Kizil, C; Tosto, G;
    2023;  
    Neurobiology of Disease;  
    Volume: 176;  
    DOI: 10.1016/j.nbd.2022.105938

  41. Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

    De Guzman, RM; Rosinger, ZJ; Rybka, KA; Jacobskind, JS; Thrasher, CA; Caballero, AL; Sturm, KL; Sharif, MS; Abbas, MS; Parra, KE; Zuloaga, KL; Justice, NJ; Zuloaga, DG;
    2023;  
    Neuroendocrinology;  
    Volume: 113;  
    Issue: 8;  
    DOI: 10.1159/000530156

    42. 2022

  42. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease

    Huang, J; Tao, Q; Ang, TFA; Farrell, J; Zhu, C; Wang, Y; Stein, TD; Lunetta, KL; Massaro, J; Mez, J; Au, R; Farrer, LA; Qiu, WQ; Zhang, X; Alzheimer’s Disease Neuroimaging Initiative;
    2022;  
    Translational Psychiatry;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1038/s41398-022-02281-6

  43. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan

    Luo, J; Agboola, F; Grant, E; Morris, JC; Masters, CL; Albert, MS; Johnson, SC; McDade, EM; Fagan, AM; Benzinger, TLS; Hassenstab, J; Bateman, RJ; Perrin, RJ; Wang, G; Li, Y; Gordon, B; Cruchaga, C; Day, GS; Levin, J; Vöglein, J; Ikeuchi, T; Suzuki, K; Allegri, RF; Xiong, C; Dominantly Inherited Alzheimer Network (DIAN);
    2022;  
    Brain: A Journal of Neurology;  
    Volume: 145;  
    Issue: 12;  
    DOI: 10.1093/brain/awac238

  44. Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

    Yang, C; Fagan, AM; Perrin, RJ; Rhinn, H; Harari, O; Cruchaga, C;
    2022;  
    Genome Medicine;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13073-022-01140-9

  45. Progranulin mutations in clinical and neuropathological Alzheimer's disease

    Vardarajan, BN; Reyes-Dumeyer, D; Piriz, AL; Lantigua, RA; Medrano, M; Rivera, D; Jiménez-Velázquez, IZ; Martin, E; Pericak-Vance, MA; Bush, W; Farrer, L; Haines, JL; Wang, L; Leung, YY; Schellenberg, G; Kukull, W; De Jager, P; Bennett, DA; Schneider, JA; Alzheimer's Disease Sequencing Project; Mayeux, R;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 12;  
    DOI: 10.1002/alz.12567

  46. Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics

    Leng, K; Kampmann, M;
    2022;  
    Genome Medicine;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13073-022-01134-7

  47. Microglial efferocytosis: Diving into the Alzheimer's disease gene pool

    Romero-Molina, C; Garretti, F; Andrews, SJ; Marcora, E; Goate, AM;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 21;  
    DOI: 10.1016/j.neuron.2022.10.015

  48. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

    Drieu, A; Du, S; Storck, SE; Rustenhoven, J; Papadopoulos, Z; Dykstra, T; Zhong, F; Kim, K; Blackburn, S; Mamuladze, T; Harari, O; Karch, CM; Bateman, RJ; Perrin, R; Farlow, M; Chhatwal, J; Dominantly Inherited Alzheimer Network; Hu, S; Randolph, GJ; Smirnov, I; Kipnis, J;
    2022;  
    Nature;  
    Volume: 611;  
    Issue: 7936;  
    DOI: 10.1038/s41586-022-05397-3

  49. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

    2022;  
    Acta Neuropathologica;  
    Volume: 144;  
    Issue: 5;  
    DOI: 10.1007/s00401-022-02454-z

  50. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

    Rickner, HD; Jiang, L; Hong, R; O'Neill, NK; Mojica, CA; Snyder, BJ; Zhang, L; Shaw, D; Medalla, M; Wolozin, B; Cheng, CS;
    2022;  
    Nature Communications;  
    Volume: 13;  
    Issue: 1;  
    DOI: 10.1038/s41467-022-34005-1

  51. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

    Novotny, BC; Fernandez, MV; Wang, C; Budde, JP; Bergmann, K; Eteleeb, AM; Bradley, J; Webster, C; Ebl, C; Norton, J; Gentsch, J; Dube, U; Wang, F; Morris, JC; Bateman, RJ; Perrin, RJ; McDade, E; Xiong, C; Chhatwal, J; Dominantly Inherited Alzheimer Network (DIAN) Study Group; Alzheimer's Disease Neuroimaging Initiative; and the Alzheimer's Disease Metabolomics Consortium (ADMC); Goate, A; Farlow, M; Schofield, P; Chui, H; Karch, CM; Cruchaga, C; Benitez, BA; Harari, O;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    DOI: 10.1002/alz.12800

  52. Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets

    Nuytemans, K; Lipkin Vasquez, M; Wang, L; Van Booven, D; Griswold, AJ; Rajabli, F; Celis, K; Oron, O; Hofmann, N; Rolati, S; Garcia-Serje, C; Zhang, S; Jin, F; Argenziano, M; Grant, SFA; Chesi, A; Brown, CD; Young, JI; Dykxhoorn, DM; Pericak-Vance, MA; Vance, JM;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
    DOI: 10.1002/alz.12534

  53. The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery

    Reyes-Dumeyer, D; Faber, K; Vardarajan, B; Goate, A; Renton, A; Chao, M; Boeve, B; Cruchaga, C; Pericak-Vance, M; Haines, JL; Rosenberg, R; Tsuang, D; Sweet, RA; Bennett, DA; Wilson, RS; Foroud, T; Mayeux, R;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
    DOI: 10.1002/alz.12514

  54. Whole genome sequencing-based copy number variations reveal novel pathways and targets in Alzheimer's disease

    Ming, C; Wang, M; Wang, Q; Neff, R; Wang, E; Shen, Q; Reddy, JS; Wang, X; Allen, M; Ertekin-Taner, N; De Jager, PL; Bennett, DA; Haroutunian, V; Schadt, E; Zhang, B;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
    DOI: 10.1002/alz.12507

  55. Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance

    Gao, Y; Felsky, D; Reyes-Dumeyer, D; Sariya, S; Rentería, MA; Ma, Y; Klein, H; Cosentino, S; De Jager, PL; Bennett, DA; Brickman, AM; Schellenberg, GD; Mayeux, R; Barral, S; CHAP, UKBB, ADNI, ROSMAP, LLFS, NIA-LOAD and ADGC consortia;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
    DOI: 10.1002/alz.12524

  56. Mosaic loss of Chromosome Y in aged human microglia

    Vermeulen, MC; Pearse, R; Young-Pearse, T; Mostafavi, S;
    2022;  
    Genome Research;  
    Volume: 32;  
    Issue: 10;  
    DOI: 10.1101/gr.276409.121

  57. Using population-scale transcriptomic and genomic data to map 3' UTR alternative polyadenylation quantitative trait loci

    Zou, X; Ding, R; Chen, W; Wang, G; Cheng, S; Wang, Q; Li, W; Li, L;
    2022;  
    STAR protocols;  
    Volume: 3;  
    Issue: 3;  
    DOI: 10.1016/j.xpro.2022.101566

  58. Identification of risk genes for Alzheimer's disease by gene embedding

    Lagisetty, Y; Bourquard, T; Al-Ramahi, I; Mangleburg, CG; Mota, S; Soleimani, S; Shulman, JM; Botas, J; Lee, K; Lichtarge, O;
    2022;  
    Cell Genomics;  
    Volume: 2;  
    Issue: 9;  
    DOI: 10.1016/j.xgen.2022.100162

  59. Association Between Mediterranean Diet and Functional Status in Older Adults: A Longitudinal Study Based on the Washington Heights-Inwood Columbia Aging Project

    Guo, J; Schupf, N; Cruz, E; Stern, Y; Mayeux, RP; Gu, Y;
    2022;  
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences;  
    Volume: 77;  
    Issue: 9;  
    DOI: 10.1093/gerona/glac011

  60. 'Fly-ing' from rare to common neurodegenerative disease mechanisms

    Ma, M; Moulton, MJ; Lu, S; Bellen, HJ;
    2022;  
    Trends in genetics: TIG;  
    Volume: 38;  
    Issue: 9;  
    DOI: 10.1016/j.tig.2022.03.018

  61. Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults

    Pa, J; Aslanyan, V; Casaletto, KB; Rentería, MA; Harrati, A; Tom, SE; Armstrong, N; Rajan, K; Avila-Rieger, J; Gu, Y; Schupf, N; Manly, JJ; Brickman, A; Zahodne, L;
    2022;  
    Neurology;  
    Volume: 99;  
    Issue: 8;  
    DOI: 10.1212/WNL.0000000000200675

  62. Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

    Ibanez, L; Heitsch, L; Carrera, C; Farias, FHG; Del Aguila, JL; Dhar, R; Budde, J; Bergmann, K; Bradley, J; Harari, O; Phuah, CL; Lemmens, R; Viana Oliveira Souza, AA; Moniche, F; Cabezas-Juan, A; Arenillas, JF; Krupinksi, J; Cullell, N; Torres-Aguila, N; Muiño, E; Cárcel-Márquez, J; Marti-Fabregas, J; Delgado-Mederos, R; Marin-Bueno, R; Hornick, A; Vives-Bauza, C; Navarro, RD; Tur, S; Jimenez, C; Obach, V; Segura, T; Serrano-Heras, G; Chung, JW; Roquer, J; Soriano-Tarraga, C; Giralt-Steinhauer, E; Mola-Caminal, M; Pera, J; Lapicka-Bodzioch, K; Derbisz, J; Davalos, A; Lopez-Cancio, E; Muñoz, L; Tatlisumak, T; Molina, C; Ribo, M; Bustamante, A; Sobrino, T; Castillo-Sanchez, J; Campos, F; Rodriguez-Castro, E; Arias-Rivas, S; Rodríguez-Yáñez, M; Herbosa, C; Ford, AL; Gutierrez-Romero, A; Uribe-Pacheco, R; Arauz, A; Lopes-Cendes, I; Lowenkopf, T; Barboza, MA; Amini, H; Stamova, B; Ander, BP; Sharp, FR; Kim, GM; Bang, OY; Jimenez-Conde, J; Slowik, A; Stribian, D; Tsai, EA; Burkly, LC; Montaner, J; Fernandez-Cadenas, I; Lee, JM; Cruchaga, C;
    2022;  
    Brain: A Journal of Neurology;  
    Volume: 145;  
    Issue: 7;  
    DOI: 10.1093/brain/awac080

  63. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry

    Rajabli, F; Beecham, GW; Hendrie, HC; Baiyewu, O; Ogunniyi, A; Gao, S; Kushch, NA; Lipkin-Vasquez, M; Hamilton-Nelson, KL; Young, JI; Dykxhoorn, DM; Nuytemans, K; Kunkle, BW; Wang, L; Jin, F; Liu, X; Feliciano-Astacio, BE; Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium; Schellenberg, GD; Dalgard, CL; Griswold, AJ; Byrd, GS; Reitz, C; Cuccaro, ML; Haines, JL; Pericak-Vance, MA; Vance, JM;
    2022;  
    PLoS genetics;  
    Volume: 18;  
    Issue: 7;  
    DOI: 10.1371/journal.pgen.1009977

  64. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

    Lee, AJ; Raghavan, NS; Bhattarai, P; Siddiqui, T; Sariya, S; Reyes-Dumeyer, D; Flowers, XE; Cardoso, SAL; De Jager, PL; Bennett, DA; Schneider, JA; Menon, V; Wang, Y; Lantigua, RA; Medrano, M; Rivera, D; Jiménez-Velázquez, IZ; Kukull, WA; Brickman, AM; Manly, JJ; Tosto, G; Kizil, C; Vardarajan, BN; Mayeux, R;
    2022;  
    Acta Neuropathologica;  
    Volume: 144;  
    Issue: 1;  
    DOI: 10.1007/s00401-022-02431-6

  65. DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution

    Zhang, S; Plummer, D; Lu, L; Cui, J; Xu, W; Wang, M; Liu, X; Prabhakar, N; Shrinet, J; Srinivasan, D; Fraser, P; Li, Y; Li, J; Jin, F;
    2022;  
    Nature Genetics;  
    Volume: 54;  
    Issue: 7;  
    DOI: 10.1038/s41588-022-01116-w

  66. Fine-mapping from summary data with the "Sum of Single Effects" model

    Zou, Y; Carbonetto, P; Wang, G; Stephens, M;
    2022;  
    PLoS genetics;  
    Volume: 18;  
    Issue: 7;  
    DOI: 10.1371/journal.pgen.1010299

  67. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

    Tcw, J; Qian, L; Pipalia, NH; Chao, MJ; Liang, SA; Shi, Y; Jain, BR; Bertelsen, SE; Kapoor, M; Marcora, E; Sikora, E; Andrews, EJ; Martini, AC; Karch, CM; Head, E; Holtzman, DM; Zhang, B; Wang, M; Maxfield, FR; Poon, WW; Goate, AM;
    2022;  
    Cell;  
    Volume: 185;  
    Issue: 13;  
    DOI: 10.1016/j.cell.2022.05.017

  68. Integration of rare expression outlier-associated variants improves polygenic risk prediction

    Smail, C; Ferraro, NM; Hui, Q; Durrant, MG; Aguirre, M; Tanigawa, Y; Keever-Keigher, MR; Rao, AS; Justesen, JM; Li, X; Gloudemans, MJ; Assimes, TL; Kooperberg, C; Reiner, AP; Huang, J; O'Donnell, CJ; Sun, YV; Million Veteran Program; Rivas, MA; Montgomery, SB;
    2022;  
    American Journal of Human Genetics;  
    Volume: 109;  
    Issue: 6;  
    DOI: 10.1016/j.ajhg.2022.04.015

  69. Chromatin accessibility profiling by ATAC-seq

    Grandi, FC; Modi, H; Kampman, L; Corces, MR;
    2022;  
    Nature Protocols;  
    Volume: 17;  
    Issue: 6;  
    DOI: 10.1038/s41596-022-00692-9

  70. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1

    Kizil, C; Sariya, S; Kim, YA; Rajabli, F; Martin, E; Reyes-Dumeyer, D; Vardarajan, B; Maldonado, A; Haines, JL; Mayeux, R; Jiménez-Velázquez, IZ; Santa-Maria, I; Tosto, G;
    2022;  
    Molecular Psychiatry;  
    Volume: 27;  
    Issue: 6;  
    DOI: 10.1038/s41380-022-01526-6

  71. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

    Horgusluoglu, E; Neff, R; Song, W; Wang, M; Wang, Q; Arnold, M; Krumsiek, J; Galindo-Prieto, B; Ming, C; Nho, K; Kastenmüller, G; Han, X; Baillie, R; Zeng, Q; Andrews, S; Cheng, H; Hao, K; Goate, A; Bennett, DA; Saykin, AJ; Kaddurah-Daouk, R; Zhang, B; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Metabolomics Consortium;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 6;  
    DOI: 10.1002/alz.12468

  72. High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

    Gannon, OJ; Robison, LS; Salinero, AE; Abi-Ghanem, C; Mansour, FM; Kelly, RD; Tyagi, A; Brawley, RR; Ogg, JD; Zuloaga, KL;
    2022;  
    Journal of Neuroinflammation;  
    Volume: 19;  
    Issue: 1;  
    DOI: 10.1186/s12974-022-02466-2

  73. Molecular Quantitative Trait Locus Mapping in Human Complex Diseases

    Olayinka, OA; O'Neill, NK; Farrer, LA; Wang, G; Zhang, X;
    2022;  
    Current Protocols;  
    Volume: 2;  
    Issue: 5;  
    DOI: 10.1002/cpz1.426

  74. Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health

    Yang, T; Cheng, B; Noble, JM; Reitz, C; Papapanou, PN;
    2022;  
    Journal of Clinical Periodontology;  
    Volume: 49;  
    Issue: 5;  
    DOI: 10.1111/jcpe.13605

  75. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

    Martens, YA; Zhao, N; Liu, C; Kanekiyo, T; Yang, AJ; Goate, AM; Holtzman, DM; Bu, G;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 8;  
    DOI: 10.1016/j.neuron.2022.03.004

  76. Integrating functional genomics with genetics to understand the biology of ALS and FTD

    Cruchaga, C;
    2022;  
    Med (New York, N.Y.);  
    Volume: 3;  
    Issue: 4;  
    DOI: 10.1016/j.medj.2022.03.008

  77. Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

    Meijer, M; Agirre, E; Kabbe, M; van Tuijn, CA; Heskol, A; Zheng, C; Mendanha Falcão, A; Bartosovic, M; Kirby, L; Calini, D; Johnson, MR; Corces, MR; Montine, TJ; Chen, X; Chang, HY; Malhotra, D; Castelo-Branco, G;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 7;  
    DOI: 10.1016/j.neuron.2021.12.034

  78. Replication study of AD-associated rare variants

    Neupane, A; Lenny, B; Budde, JP; Wang, F; Norton, J; Morris, JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga, C; Fernández, MV;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 4;  
    DOI: 10.1002/alz.12583

  79. Soluble TREM2: Innocent bystander or active player in neurological diseases?

    Filipello, F; Goldsbury, C; You, SF; Locca, A; Karch, CM; Piccio, L;
    2022;  
    Neurobiology of Disease;  
    Volume: 165;  
    DOI: 10.1016/j.nbd.2022.105630

  80. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns

    Jin, B; Capra, JA; Benchek, P; Wheeler, N; Naj, AC; Hamilton-Nelson, KL; Farrell, JJ; Leung, YY; Kunkle, B; Vadarajan, B; Schellenberg, GD; Mayeux, R; Wang, L; Farrer, LA; Pericak-Vance, MA; Martin, ER; Haines, JL; Crawford, DC; Bush, WS;
    2022;  
    Genome Research;  
    Volume: 32;  
    Issue: 4;  
    DOI: 10.1101/gr.276069.121

  81. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

    Chen, H; Eteleeb, A; Wang, C; Fernandez, MV; Budde, JP; Bergmann, K; Norton, J; Wang, F; Ebl, C; Morris, JC; Perrin, RJ; Bateman, RJ; McDade, E; Xiong, C; Goate, A; Farlow, M; Chhatwal, J; Schofield, PR; Chui, H; Harari, O; Cruchaga, C; Ibanez, L; Dominantly Inherited Alzheimer Network;
    2022;  
    Acta Neuropathologica Communications;  
    Volume: 10;  
    Issue: 1;  
    DOI: 10.1186/s40478-022-01328-5

  82. APOE4 confers transcriptomic and functional alterations to primary mouse microglia

    Machlovi, SI; Neuner, SM; Hemmer, BM; Khan, R; Liu, Y; Huang, M; Zhu, JD; Castellano, JM; Cai, D; Marcora, E; Goate, AM;
    2022;  
    Neurobiology of Disease;  
    Volume: 164;  
    DOI: 10.1016/j.nbd.2022.105615

  83. Social network characteristics moderate associations between cortical thickness and cognitive functioning in older adults

    Sharifian, N; Zaheed, AB; Morris, EP; Sol, K; Manly, JJ; Schupf, N; Mayeux, R; Brickman, AM; Zahodne, LB;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 2;  
    DOI: 10.1002/alz.12383

  84. Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease

    Zhang, X; Farrell, JJ; Tong, T; Hu, J; Zhu, C; Alzheimer's Disease Sequencing Project; Wang, L; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GD; Lunetta, KL; Farrer, LA;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 2;  
    DOI: 10.1002/alz.12396

  85. Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

    Bigley, TM; Xiong, M; Ali, M; Chen, Y; Wang, C; Serrano, JR; Eteleeb, A; Harari, O; Yang, L; Patel, SJ; Cruchaga, C; Yokoyama, WM; Holtzman, DM;
    2022;  
    Molecular Neurodegeneration;  
    Volume: 17;  
    Issue: 1;  
    DOI: 10.1186/s13024-021-00514-8

  86. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

    Xu, P; Wang, M; Song, W; Wang, Q; Yuan, G; Sudmant, PH; Zare, H; Tu, Z; Orr, ME; Zhang, B;
    2022;  
    Molecular Neurodegeneration;  
    Volume: 17;  
    Issue: 1;  
    DOI: 10.1186/s13024-021-00507-7

  87. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population

    Angevaare, MJ; Vonk, JMJ; Bertola, L; Zahodne, L; Watson, CW; Boehme, A; Schupf, N; Mayeux, R; Geerlings, MI; Manly, JJ;
    2022;  
    Neurology;  
    Volume: 98;  
    Issue: 1;  
    DOI: 10.1212/WNL.0000000000013017

  88. Genome-wide association study and functional validation implicates JADE1 in tauopathy

    Farrell, K; Kim, S; Han, N; Iida, MA; Gonzalez, EM; Otero-Garcia, M; Walker, JM; Richardson, TE; Renton, AE; Andrews, SJ; Fulton-Howard, B; Humphrey, J; Vialle, RA; Bowles, KR; de Paiva Lopes, K; Whitney, K; Dangoor, DK; Walsh, H; Marcora, E; Hefti, MM; Casella, A; Sissoko, CT; Kapoor, M; Novikova, G; Udine, E; Wong, G; Tang, W; Bhangale, T; Hunkapiller, J; Ayalon, G; Graham, RR; Cherry, JD; Cortes, EP; Borukov, VY; McKee, AC; Stein, TD; Vonsattel, J; Teich, AF; Gearing, M; Glass, J; Troncoso, JC; Frosch, MP; Hyman, BT; Dickson, DW; Murray, ME; Attems, J; Flanagan, ME; Mao, Q; Mesulam, M; Weintraub, S; Woltjer, RL; Pham, T; Kofler, J; Schneider, JA; Yu, L; Purohit, DP; Haroutunian, V; Hof, PR; Gandy, S; Sano, M; Beach, TG; Poon, W; Kawas, CH; Corrada, MM; Rissman, RA; Metcalf, J; Shuldberg, S; Salehi, B; Nelson, PT; Trojanowski, JQ; Lee, EB; Wolk, DA; McMillan, CT; Keene, CD; Latimer, CS; Montine, TJ; Kovacs, GG; Lutz, MI; Fischer, P; Perrin, RJ; Cairns, NJ; Franklin, EE; Cohen, HT; Raj, T; Cobos, I; Frost, B; Goate, A; White Iii, CL; Crary, JF;
    2022;  
    Acta Neuropathologica;  
    Volume: 143;  
    Issue: 1;  
    DOI: 10.1007/s00401-021-02379-z

  89. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

    Ali, M; Sung, YJ; Wang, F; Fernández, MV; Morris, JC; Fagan, AM; Blennow, K; Zetterberg, H; Heslegrave, A; Johansson, PM; Svensson, J; Nellgård, B; Lleó, A; Alcolea, D; Clarimon, J; Rami, L; Molinuevo, JL; Suárez-Calvet, M; Morenas-Rodríguez, E; Kleinberger, G; Haass, C; Ewers, M; Levin, J; Farlow, MR; Perrin, RJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN); Cruchaga, C;
    2022;  
    PloS One;  
    Volume: 17;  
    Issue: 5;  
    DOI: 10.1371/journal.pone.0267298

  90. Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach

    Timsina, J; Gomez-Fonseca, D; Wang, L; Do, A; Western, D; Alvarez, I; Aguilar, M; Pastor, P; Henson, RL; Herries, E; Xiong, C; Schindler, SE; Fagan, AM; Bateman, RJ; Farlow, M; Morris, JC; Perrin, RJ; Moulder, K; Hassenstab, J; Vöglein, J; Chhatwal, J; Mori, H; Alzheimer’s Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network Consortia; Sung, YJ; Cruchaga, C;
    2022;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 89;  
    Issue: 1;  
    DOI: 10.3233/JAD-220399

    91. 2021

  91. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

    Moulton, MJ; Barish, S; Ralhan, I; Chang, J; Goodman, LD; Harland, JG; Marcogliese, PC; Johansson, JO; Ioannou, MS; Bellen, HJ;
    2021;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 118;  
    Issue: 52;  
    DOI: 10.1073/pnas.2112095118

  92. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

    Guo, J; Brickman, AM; Manly, JJ; Reitz, C; Schupf, N; Mayeux, RP; Gu, Y;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 12;  
    DOI: 10.1002/alz.12359

  93. Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP

    Wani, A; Weihl, CC;
    2021;  
    Autophagy;  
    Volume: 17;  
    Issue: 12;  
    DOI: 10.1080/15548627.2021.1985880

  94. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

    Lagomarsino, VN; Pearse, RV; Liu, L; Hsieh, Y; Fernandez, MA; Vinton, EA; Paull, D; Felsky, D; Tasaki, S; Gaiteri, C; Vardarajan, B; Lee, H; Muratore, CR; Benoit, CR; Chou, V; Fancher, SB; He, A; Merchant, JP; Duong, DM; Martinez, H; Zhou, M; Bah, F; Vicent, MA; Stricker, JMS; Xu, J; Dammer, EB; Levey, AI; Chibnik, LB; Menon, V; Seyfried, NT; De Jager, PL; Noggle, S; Selkoe, DJ; Bennett, DA; Young-Pearse, TL;
    2021;  
    Neuron;  
    Volume: 109;  
    Issue: 21;  
    DOI: 10.1016/j.neuron.2021.08.003

  95. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

    Jiang, L; Lin, W; Zhang, C; Ash, PEA; Verma, M; Kwan, J; van Vliet, E; Yang, Z; Cruz, AL; Boudeau, S; Maziuk, BF; Lei, S; Song, J; Alvarez, VE; Hovde, S; Abisambra, JF; Kuo, M; Kanaan, N; Murray, ME; Crary, JF; Zhao, J; Cheng, J; Petrucelli, L; Li, H; Emili, A; Wolozin, B;
    2021;  
    Molecular Cell;  
    Volume: 81;  
    Issue: 20;  
    DOI: 10.1016/j.molcel.2021.07.038

  96. KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease

    Siddiqui, T; Bhattarai, P; Popova, S; Cosacak, MI; Sariya, S; Zhang, Y; Mayeux, R; Tosto, G; Kizil, C;
    2021;  
    Cells;  
    Volume: 10;  
    Issue: 10;  
    DOI: 10.3390/cells10102748

  97. Large scale enzyme based xenobiotic identification for exposomics

    Liu, KH; Lee, CM; Singer, G; Bais, P; Castellanos, F; Woodworth, MH; Ziegler, TR; Kraft, CS; Miller, GW; Li, S; Go, Y; Morgan, ET; Jones, DP;
    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1038/s41467-021-25698-x

  98. Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease

    Li, F; Eteleeb, A; Buchser, W; Wang, G; Xiong, C; Payne, PR; McDade, E; Karch, CM; Harari, O; Cruchaga, C;
    2021;  
    bioRxiv: The Preprint Server for Biology;  
    DOI: 10.1101/2021.08.30.458295

  99. Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics

    Sariya, S; Felsky, D; Reyes-Dumeyer, D; Lali, R; Lantigua, RA; Vardarajan, B; Jiménez-Velázquez, IZ; Haines, JL; Shellenberg, GD; Pericak-Vance, MA; Paré, G; Mayeux, R; Tosto, G;
    2021;  
    Annals of Neurology;  
    Volume: 90;  
    Issue: 3;  
    DOI: 10.1002/ana.26131

  100. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

    Yang, C; Farias, FHG; Ibanez, L; Suhy, A; Sadler, B; Fernandez, MV; Wang, F; Bradley, JL; Eiffert, B; Bahena, JA; Budde, JP; Li, Z; Dube, U; Sung, YJ; Mihindukulasuriya, KA; Morris, JC; Fagan, AM; Perrin, RJ; Benitez, BA; Rhinn, H; Harari, O; Cruchaga, C;
    2021;  
    Nature Neuroscience;  
    Volume: 24;  
    Issue: 9;  
    DOI: 10.1038/s41593-021-00886-6

  101. Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression

    Saito, ER; Miller, JB; Harari, O; Cruchaga, C; Mihindukulasuriya, KA; Kauwe, JSK; Bikman, BT;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 9;  
    DOI: 10.1002/alz.12310

  102. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis

    Cao, J; Huang, M; Guo, L; Zhu, L; Hou, J; Zhang, L; Pero, A; Ng, S; El Gaamouch, F; Elder, G; Sano, M; Goate, A; Tcw, J; Haroutunian, V; Zhang, B; Cai, D;
    2021;  
    Molecular Psychiatry;  
    Volume: 26;  
    Issue: 9;  
    DOI: 10.1038/s41380-020-0824-3

  103. Associations Between Loneliness, Reading Ability and Episodic Memory in Non-Hispanic Black and White Older Adults

    Sol, K; Sharifian, N; Manly, JJ; Brickman, AM; Zahodne, LB;
    2021;  
    Archives of Clinical Neuropsychology: The Official Journal of the National Academy of Neuropsychologists;  
    Volume: 36;  
    Issue: 6;  
    DOI: 10.1093/arclin/acab001

  104. Advances in Genetic and Molecular Understanding of Alzheimer's Disease

    Ibanez, L; Cruchaga, C; Fernández, MV;
    2021;  
    Genes;  
    Volume: 12;  
    Issue: 8;  
    DOI: 10.3390/genes12081247

  105. Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study

    Brickman, AM; Manly, JJ; Honig, LS; Sanchez, D; Reyes-Dumeyer, D; Lantigua, RA; Lao, PJ; Stern, Y; Vonsattel, JP; Teich, AF; Airey, DC; Proctor, NK; Dage, JL; Mayeux, R;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 8;  
    DOI: 10.1002/alz.12301

  106. Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery

    Chung, MK; Rappaport, SM; Wheelock, CE; Nguyen, VK; van der Meer, TP; Miller, GW; Vermeulen, R; Patel, CJ;
    2021;  
    Environmental Health Perspectives;  
    Volume: 129;  
    Issue: 8;  
    DOI: 10.1289/EHP8327

  107. Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome

    Wu, HM; Goate, AM; O'Reilly, PF;
    2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1038/s41398-021-01518-0

  108. Neuronal VCP loss of function recapitulates FTLD-TDP pathology

    Wani, A; Zhu, J; Ulrich, JD; Eteleeb, A; Sauerbeck, AD; Reitz, SJ; Arhzaouy, K; Ikenaga, C; Yuede, CM; Pittman, SK; Wang, F; Li, S; Benitez, BA; Cruchaga, C; Kummer, TT; Harari, O; Chou, T; Schröder, R; Clemen, CS; Weihl, CC;
    2021;  
    Cell Reports;  
    Volume: 36;  
    Issue: 3;  
    DOI: 10.1016/j.celrep.2021.109399

  109. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds

    Griswold, AJ; Celis, K; Bussies, PL; Rajabli, F; Whitehead, PL; Hamilton-Nelson, KL; Beecham, GW; Dykxhoorn, DM; Nuytemans, K; Wang, L; Gardner, OK; Dorfsman, DA; Bigio, EH; Mesulam, MM; Weintraub, S; Geula, C; Gearing, M; McGrath-Martinez, E; Dalgard, CL; Scott, WK; Haines, JL; Pericak-Vance, MA; Young, JI; Vance, JM;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 7;  
    DOI: 10.1002/alz.12287

  110. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1038/s41467-021-22491-8

  111. Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease

    Qin, W; Zhou, A; Zuo, X; Jia, L; Li, F; Wang, Q; Li, Y; Wei, Y; Jin, H; Cruchaga, C; Benitez, BA; Jia, J;
    2021;  
    Human Molecular Genetics;  
    Volume: 30;  
    Issue: 9;  
    DOI: 10.1093/hmg/ddab090

  112. Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions

    2021;  
    Medicinal Research Reviews;  
    Volume: 41;  
    Issue: 3;  
    DOI: 10.1002/med.21764

  113. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

    Da Mesquita, S; Papadopoulos, Z; Dykstra, T; Brase, L; Farias, FG; Wall, M; Jiang, H; Kodira, CD; de Lima, KA; Herz, J; Louveau, A; Goldman, DH; Salvador, AF; Onengut-Gumuscu, S; Farber, E; Dabhi, N; Kennedy, T; Milam, MG; Baker, W; Smirnov, I; Rich, SS; Dominantly Inherited Alzheimer Network; Benitez, BA; Karch, CM; Perrin, RJ; Farlow, M; Chhatwal, JP; Holtzman, DM; Cruchaga, C; Harari, O; Kipnis, J;
    2021;  
    Nature;  
    Volume: 593;  
    Issue: 7858;  
    DOI: 10.1038/s41586-021-03489-0

  114. Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue

    Patel, D; Zhang, X; Farrell, JJ; Chung, J; Stein, TD; Lunetta, KL; Farrer, LA;
    2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1038/s41398-021-01373-z

  115. African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

    Schindler, SE; Cruchaga, C; Joseph, A; McCue, L; Farias, FHG; Wilkins, CH; Deming, Y; Henson, RL; Mikesell, RJ; Piccio, L; Llibre-Guerra, JJ; Moulder, KL; Fagan, AM; Ances, BM; Benzinger, TLS; Xiong, C; Holtzman, DM; Morris, JC;
    2021;  
    Neurology. Genetics;  
    Volume: 7;  
    Issue: 2;  
    DOI: 10.1212/NXG.0000000000000571

  116. Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

    Kirola, L; Budde, JP; Wang, F; Norton, J; Morris, JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga, C; Fernández, MV;
    2021;  
    Acta Neuropathologica;  
    Volume: 141;  
    Issue: 4;  
    DOI: 10.1007/s00401-021-02271-w

  117. Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants

    Patel, D; Zhang, X; Farrell, JJ; Lunetta, KL; Farrer, LA;
    2021;  
    Genes;  
    Volume: 12;  
    Issue: 3;  
    DOI: 10.3390/genes12030419

  118. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

    Novikova, G; Kapoor, M; Tcw, J; Abud, EM; Efthymiou, AG; Chen, SX; Cheng, H; Fullard, JF; Bendl, J; Liu, Y; Roussos, P; Björkegren, JL; Liu, Y; Poon, WW; Hao, K; Marcora, E; Goate, AM;
    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1038/s41467-021-21823-y

  119. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

    Ash, PEA; Lei, S; Shattuck, J; Boudeau, S; Carlomagno, Y; Medalla, M; Mashimo, BL; Socorro, G; Al-Mohanna, LFA; Jiang, L; Öztürk, MM; Knobel, M; Ivanov, P; Petrucelli, L; Wegmann, S; Kanaan, NM; Wolozin, B;
    2021;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 118;  
    Issue: 9;  
    DOI: 10.1073/pnas.2014188118

  120. Socioeconomic and psychosocial mechanisms underlying racial/ethnic disparities in cognition among older adults

    Zahodne, LB; Sharifian, N; Kraal, AZ; Zaheed, AB; Sol, K; Morris, EP; Schupf, N; Manly, JJ; Brickman, AM;
    2021;  
    Neuropsychology;  
    Volume: 35;  
    Issue: 3;  
    DOI: 10.1037/neu0000720

  121. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers

    Fulton-Howard, B; Goate, AM; Adelson, RP; Koppel, J; Gordon, ML; Alzheimer's Disease Genetics Consortium; Barzilai, N; Atzmon, G; Davies, P; Freudenberg-Hua, Y;
    2021;  
    Neurobiology of Aging;  
    Volume: 99;  
    DOI: 10.1016/j.neurobiolaging.2020.09.014

  122. Long runs of homozygosity are associated with Alzheimer's disease

    2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1038/s41398-020-01145-1

  123. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

    2021;  
    Neuron;  
    Volume: 109;  
    Issue: 2;  
    DOI: 10.1016/j.neuron.2020.11.002

  124. The variant call format provides efficient and robust storage of GWAS summary statistics

    Lyon, MS; Andrews, SJ; Elsworth, B; Gaunt, TR; Hemani, G; Marcora, E;
    2021;  
    Genome Biology;  
    Volume: 22;  
    Issue: 1;  
    DOI: 10.1186/s13059-020-02248-0

  125. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    Kunkle, BW; Schmidt, M; Klein, H; Naj, AC; Hamilton-Nelson, KL; Larson, EB; Evans, DA; De Jager, PL; Crane, PK; Buxbaum, JD; Ertekin-Taner, N; Barnes, LL; Fallin, MD; Manly, JJ; Go, RCP; Obisesan, TO; Kamboh, MI; Bennett, DA; Hall, KS; Goate, AM; Foroud, TM; Martin, ER; Wang, L; Byrd, GS; Farrer, LA; Haines, JL; Schellenberg, GD; Mayeux, R; Pericak-Vance, MA; Reitz, C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC); Graff-Radford, NR; Martinez, I; Ayodele, T; Logue, MW; Cantwell, LB; Jean-Francois, M; Kuzma, AB; Adams, LD; Vance, JM; Cuccaro, ML; Chung, J; Mez, J; Lunetta, KL; Jun, GR; Lopez, OL; Hendrie, HC; Reiman, EM; Kowall, NW; Leverenz, JB; Small, SA; Levey, AI; Golde, TE; Saykin, AJ; Starks, TD; Albert, MS; Hyman, BT; Petersen, RC; Sano, M; Wisniewski, T; Vassar, R; Kaye, JA; Henderson, VW; DeCarli, C; LaFerla, FM; Brewer, JB; Miller, BL; Swerdlow, RH; Van Eldik, LJ; Paulson, HL; Trojanowski, JQ; Chui, HC; Rosenberg, RN; Craft, S; Grabowski, TJ; Asthana, S; Morris, JC; Strittmatter, SM; Kukull, WA;
    2021;  
    JAMA neurology;  
    Volume: 78;  
    Issue: 1;  
    DOI: 10.1001/jamaneurol.2020.3536

  126. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    Kunkle, BW; Schmidt, M; Klein, H; Naj, AC; Hamilton-Nelson, KL; Larson, EB; Evans, DA; De Jager, PL; Crane, PK; Buxbaum, JD; Ertekin-Taner, N; Barnes, LL; Fallin, MD; Manly, JJ; Go, RCP; Obisesan, TO; Kamboh, MI; Bennett, DA; Hall, KS; Goate, AM; Foroud, TM; Martin, ER; Wang, L; Byrd, GS; Farrer, LA; Haines, JL; Schellenberg, GD; Mayeux, R; Pericak-Vance, MA; Reitz, C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC); Graff-Radford, NR; Martinez, I; Ayodele, T; Logue, MW; Cantwell, LB; Jean-Francois, M; Kuzma, AB; Adams, LD; Vance, JM; Cuccaro, ML; Chung, J; Mez, J; Lunetta, KL; Jun, GR; Lopez, OL; Hendrie, HC; Reiman, EM; Kowall, NW; Leverenz, JB; Small, SA; Levey, AI; Golde, TE; Saykin, AJ; Starks, TD; Albert, MS; Hyman, BT; Petersen, RC; Sano, M; Wisniewski, T; Vassar, R; Kaye, JA; Henderson, VW; DeCarli, C; LaFerla, FM; Brewer, JB; Miller, BL; Swerdlow, RH; Van Eldik, LJ; Paulson, HL; Trojanowski, JQ; Chui, HC; Rosenberg, RN; Craft, S; Grabowski, TJ; Asthana, S; Morris, JC; Strittmatter, SM; Kukull, WA;
    2021;  
    JAMA neurology;  
    Volume: 78;  
    Issue: 1;  
    DOI: 10.1001/jamaneurol.2020.3536

  127. Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response

    Pimenova, AA; Herbinet, M; Gupta, I; Machlovi, SI; Bowles, KR; Marcora, E; Goate, AM;
    2021;  
    Neurobiology of Disease;  
    Volume: 148;  
    DOI: 10.1016/j.nbd.2020.105217

  128. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

    Neff, RA; Wang, M; Vatansever, S; Guo, L; Ming, C; Wang, Q; Wang, E; Horgusluoglu-Moloch, E; Song, W; Li, A; Castranio, EL; Tcw, J; Ho, L; Goate, A; Fossati, V; Noggle, S; Gandy, S; Ehrlich, ME; Katsel, P; Schadt, E; Cai, D; Brennand, KJ; Haroutunian, V; Zhang, B;
    2021;  
    Science Advances;  
    Volume: 7;  
    Issue: 2;  
    DOI: 10.1126/sciadv.abb5398

  129. Positive Psychosocial Factors and Cognitive Decline in Ethnically Diverse Older Adults

    Zahodne, LB; Sharifian, N; Kraal, AZ; Sol, K; Zaheed, AB; Manly, JJ; Brickman, AM;
    2021;  
    Journal of the International Neuropsychological Society: JINS;  
    Volume: 27;  
    Issue: 1;  
    DOI: 10.1017/S1355617720000648

  130. Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome

    Andrews, SJ; Fulton-Howard, B; O'Reilly, P; Marcora, E; Goate, AM; collaborators of the Alzheimer's Disease Genetics Consortium;
    2021;  
    Annals of Neurology;  
    Volume: 89;  
    Issue: 1;  
    DOI: 10.1002/ana.25918

  131. Education differentially contributes to cognitive reserve across racial/ethnic groups

    Avila, JF; Rentería, MA; Jones, RN; Vonk, JMJ; Turney, I; Sol, K; Seblova, D; Arias, F; Hill-Jarrett, T; Levy, S; Meyer, O; Racine, AM; Tom, SE; Melrose, RJ; Deters, K; Medina, LD; Carrión, CI; Díaz-Santos, M; Byrd, DR; Chesebro, A; Colon, J; Igwe, KC; Maas, B; Brickman, AM; Schupf, N; Mayeux, R; Manly, JJ;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 1;  
    DOI: 10.1002/alz.12176

  132. Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease

    Xue, D; Bush, WS; Renton, AE; Marcora, EA; Bis, JC; Kunkle, BW; Alzheimer's Disease Sequencing Project; Boerwinkle, E; DeStefano, AL; Farrer, L; Goate, A; Mayeux, R; Pericak-Vance, M; Schellenberg, G; Seshadri, S; Wijsman, E; Haines, JL; Blue, EE;
    2021;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 13;  
    Issue: 1;  
    DOI: 10.1002/dad2.12255

  133. Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

    Huq, AJ; Fulton-Howard, B; Riaz, M; Laws, S; Sebra, R; Ryan, J; Alzheimer's Disease Genetics Consortium; Renton, AE; Goate, AM; Masters, CL; Storey, E; Shah, RC; Murray, A; McNeil, J; Winship, I; James, PA; Lacaze, P;
    2021;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 13;  
    Issue: 1;  
    DOI: 10.1002/dad2.12226

  134. Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer's Disease in a Multiethnic Population

    Nishikawa, M; Brickman, AM; Manly, JJ; Schupf, N; Mayeux, RP; Gu, Y;
    2021;  
    Current Alzheimer Research;  
    Volume: 18;  
    Issue: 12;  
    DOI: 10.2174/1567205019666211222115142

    135. 2020

  135. Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis

    Lananna, BV; McKee, CA; King, MW; Del-Aguila, JL; Dimitry, JM; Farias, FHG; Nadarajah, CJ; Xiong, DD; Guo, C; Cammack, AJ; Elias, JA; Zhang, J; Cruchaga, C; Musiek, ES;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 574;  
    DOI: 10.1126/scitranslmed.aax3519

  136. Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics

    Podleśny-Drabiniok, A; Marcora, E; Goate, AM;
    2020;  
    Trends in Neurosciences;  
    Volume: 43;  
    Issue: 12;  
    DOI: 10.1016/j.tins.2020.10.002

  137. A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease

    Zhao, L; Zhang, Z; Rodriguez, SMB; Vardarajan, BN; Renton, AE; Goate, AM; Mayeux, R; Wang, GT; Leal, SM;
    2020;  
    European journal of human genetics: EJHG;  
    Volume: 28;  
    Issue: 12;  
    DOI: 10.1038/s41431-020-0703-z

  138. Dietary fatty acids and risk of Alzheimer's disease and related dementias: Observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP)

    Gustafson, DR; Bäckman, K; Scarmeas, N; Stern, Y; Manly, JJ; Mayeux, R; Gu, Y;
    2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 12;  
    DOI: 10.1002/alz.12154

  139. Family Ties and Aging in a Multiethnic Cohort

    Ying, G; Vonk, JMJ; Sol, K; Brickman, AM; Manly, JJ; Zahodne, LB;
    2020;  
    Journal of Aging and Health;  
    Volume: 32;  
    Issue: 10;  
    DOI: 10.1177/0898264320935238

  140. Sampling interstitial fluid from human skin using a microneedle patch

    Samant, PP; Niedzwiecki, MM; Raviele, N; Tran, V; Mena-Lapaix, J; Walker, DI; Felner, EI; Jones, DP; Miller, GW; Prausnitz, MR;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 571;  
    DOI: 10.1126/scitranslmed.aaw0285

  141. Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

    Ibanez, L; Bahena, JA; Yang, C; Dube, U; Farias, FHG; Budde, JP; Bergmann, K; Brenner-Webster, C; Morris, JC; Perrin, RJ; Cairns, NJ; O'Donnell, J; Álvarez, I; Diez-Fairen, M; Aguilar, M; Miller, R; Davis, AA; Pastor, P; Kotzbauer, P; Campbell, MC; Perlmutter, JS; Rhinn, H; Harari, O; Cruchaga, C; Benitez, BA;
    2020;  
    Acta Neuropathologica Communications;  
    Volume: 8;  
    Issue: 1;  
    DOI: 10.1186/s40478-020-01072-8

  142. Assessment of Leisure Time Physical Activity and Brain Health in a Multiethnic Cohort of Older Adults

    Gu, Y; Beato, JM; Amarante, E; Chesebro, AG; Manly, JJ; Schupf, N; Mayeux, RP; Brickman, AM;
    2020;  
    JAMA network open;  
    Volume: 3;  
    Issue: 11;  
    DOI: 10.1001/jamanetworkopen.2020.26506

  143. Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease

    Stamm, BC; Lao, PJ; Rizvi, B; Colon, J; Igwe, K; Chesebro, AG; Maas, B; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences;  
    Volume: 75;  
    Issue: 11;  
    DOI: 10.1093/gerona/glz291

  144. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

    Hur, J; Frost, GR; Wu, X; Crump, C; Pan, SJ; Wong, E; Barros, M; Li, T; Nie, P; Zhai, Y; Wang, JC; Tcw, J; Guo, L; McKenzie, A; Ming, C; Zhou, X; Wang, M; Sagi, Y; Renton, AE; Esposito, BT; Kim, Y; Sadleir, KR; Trinh, I; Rissman, RA; Vassar, R; Zhang, B; Johnson, DS; Masliah, E; Greengard, P; Goate, A; Li, Y;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7831;  
    DOI: 10.1038/s41586-020-2681-2

  145. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP)

    Zhao, C; Tsapanou, A; Manly, J; Schupf, N; Brickman, AM; Gu, Y;
    2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 10;  
    DOI: 10.1002/alz.12096

  146. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    Cignarella, F; Filipello, F; Bollman, B; Cantoni, C; Locca, A; Mikesell, R; Manis, M; Ibrahim, A; Deng, L; Benitez, BA; Cruchaga, C; Licastro, D; Mihindukulasuriya, K; Harari, O; Buckland, M; Holtzman, DM; Rosenthal, A; Schwabe, T; Tassi, I; Piccio, L;
    2020;  
    Acta Neuropathologica;  
    Volume: 140;  
    Issue: 4;  
    DOI: 10.1007/s00401-020-02193-z

  147. Negative feedback control of neuronal activity by microglia

    Badimon, A; Strasburger, HJ; Ayata, P; Chen, X; Nair, A; Ikegami, A; Hwang, P; Chan, AT; Graves, SM; Uweru, JO; Ledderose, C; Kutlu, MG; Wheeler, MA; Kahan, A; Ishikawa, M; Wang, Y; Loh, YE; Jiang, JX; Surmeier, DJ; Robson, SC; Junger, WG; Sebra, R; Calipari, ES; Kenny, PJ; Eyo, UB; Colonna, M; Quintana, FJ; Wake, H; Gradinaru, V; Schaefer, A;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7829;  
    DOI: 10.1038/s41586-020-2777-8

  148. Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

    Zhang, Q; Sidorenko, J; Couvy-Duchesne, B; Marioni, RE; Wright, MJ; Goate, AM; Marcora, E; Huang, K; Porter, T; Laws, SM; Australian Imaging Biomarkers and Lifestyle (AIBL) Study; Sachdev, PS; Mather, KA; Armstrong, NJ; Thalamuthu, A; Brodaty, H; Yengo, L; Yang, J; Wray, NR; McRae, AF; Visscher, PM;
    2020;  
    Nature Communications;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1038/s41467-020-18534-1

  149. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    Ewers, M; Biechele, G; Suárez-Calvet, M; Sacher, C; Blume, T; Morenas-Rodriguez, E; Deming, Y; Piccio, L; Cruchaga, C; Kleinberger, G; Shaw, L; Trojanowski, JQ; Herms, J; Dichgans, M; Alzheimer's Disease Neuroimaging Initiative (ADNI); Brendel, M; Haass, C; Franzmeier, N;
    2020;  
    EMBO molecular medicine;  
    Volume: 12;  
    Issue: 9;  
    DOI: 10.15252/emmm.202012308

  150. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

    Lancour, D; Dupuis, J; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GC; Crovella, M; Farrer, LA; Kasif, S;
    2020;  
    Alzheimer's Research & Therapy;  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1186/s13195-020-00674-7

  151. Genetic architecture of Alzheimer's disease

    Neuner, SM; Tcw, J; Goate, AM;
    2020;  
    Neurobiology of Disease;  
    Volume: 143;  
    DOI: 10.1016/j.nbd.2020.104976

  152. Synonymous variants associated with Alzheimer disease in multiplex families

    Tang, M; Alaniz, ME; Felsky, D; Vardarajan, B; Reyes-Dumeyer, D; Lantigua, R; Medrano, M; Bennett, DA; de Jager, PL; Mayeux, R; Santa-Maria, I; Reitz, C;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 4;  
    DOI: 10.1212/NXG.0000000000000450

  153. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

    Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; Cantwell, L; Charbonnier, C; Chung, J; Crane, PK; Cruchaga, C; Cupples, LA; Dartigues, J; Debette, S; Deleuze, J; Fulton, L; Gabriel, SB; Genin, E; Gibbs, RA; Goate, A; Grenier-Boley, B; Gupta, N; Haines, JL; Havulinna, AS; Helisalmi, S; Hiltunen, M; Howrigan, DP; Ikram, MA; Kaprio, J; Konrad, J; Kuzma, A; Lander, ES; Lathrop, M; Lehtimäki, T; Lin, H; Mattila, K; Mayeux, R; Muzny, DM; Nasser, W; Neale, B; Nho, K; Nicolas, G; Patel, D; Pericak-Vance, MA; Perola, M; Psaty, BM; Quenez, O; Rajabli, F; Redon, R; Reitz, C; Remes, AM; Salomaa, V; Sarnowski, C; Schmidt, H; Schmidt, M; Schmidt, R; Soininen, H; Thornton, TA; Tosto, G; Tzourio, C; van der Lee, SJ; van Duijn, CM; Valladares, O; Vardarajan, B; Wang, L; Wang, W; Wijsman, E; Wilson, RK; Witten, D; Worley, KC; Zhang, X; Alzheimer’s Disease Sequencing Project; Bellenguez, C; Lambert, J; Kurki, MI; Palotie, A; Daly, M; Boerwinkle, E; Lunetta, KL; Destefano, AL; Dupuis, J; Martin, ER; Schellenberg, GD; Seshadri, S; Naj, AC; Fornage, M; Farrer, LA;
    2020;  
    Molecular Psychiatry;  
    Volume: 25;  
    Issue: 8;  
    DOI: 10.1038/s41380-018-0112-7

  154. Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

    Sherva, R; Gross, A; Mukherjee, S; Koesterer, R; Amouyel, P; Bellenguez, C; Dufouil, C; Bennett, DA; Chibnik, L; Cruchaga, C; Del-Aguila, J; Farrer, LA; Mayeux, R; Munsie, L; Winslow, A; Newhouse, S; Saykin, AJ; Kauwe, JSK; Alzheimer's Disease Genetics Consortium; Crane, PK; Green, RC;
    2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 8;  
    DOI: 10.1002/alz.12106

  155. Sex-dependent autosomal effects on clinical progression of Alzheimer's disease

    Fan, CC; Banks, SJ; Thompson, WK; Chen, C; McEvoy, LK; Tan, CH; Kukull, W; Bennett, DA; Farrer, LA; Mayeux, R; Schellenberg, GD; Andreassen, OA; Desikan, R; Dale, AM;
    2020;  
    Brain: A Journal of Neurology;  
    Volume: 143;  
    Issue: 7;  
    DOI: 10.1093/brain/awaa164

  156. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

    Castillo-Barnes, D; Su, L; Ramírez, J; Salas-Gonzalez, D; Martinez-Murcia, FJ; Illan, IA; Segovia, F; Ortiz, A; Cruchaga, C; Farlow, MR; Xiong, C; Graff-Radford, NR; Schofield, PR; Masters, CL; Salloway, S; Jucker, M; Mori, H; Levin, J; Gorriz, JM; Dominantly Inherited Alzheimer Network (DIAN);
    2020;  
    An International Journal on Information Fusion;  
    Volume: 58;  
    DOI: 10.1016/j.inffus.2020.01.001

  157. Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease

    Bussies, PL; Rajabli, F; Griswold, A; Dorfsman, DA; Whitehead, P; Adams, LD; Mena, PR; Cuccaro, M; Haines, JL; Byrd, GS; Beecham, GW; Pericak-Vance, MA; Young, JI; Vance, JM;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 2;  
    DOI: 10.1212/NXG.0000000000000404

  158. Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

    Andrews, SJ; Fulton-Howard, B; Goate, A;
    2020;  
    The Lancet. Neurology;  
    Volume: 19;  
    Issue: 4;  
    DOI: 10.1016/S1474-4422(19)30435-1

  159. APOE genotype regulates pathology and disease progression in synucleinopathy

    Davis, AA; Inman, CE; Wargel, ZM; Dube, U; Freeberg, BM; Galluppi, A; Haines, JN; Dhavale, DD; Miller, R; Choudhury, FA; Sullivan, PM; Cruchaga, C; Perlmutter, JS; Ulrich, JD; Benitez, BA; Kotzbauer, PT; Holtzman, DM;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 529;  
    DOI: 10.1126/scitranslmed.aay3069

  160. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs

    Ramdhani, S; Navarro, E; Udine, E; Efthymiou, AG; Schilder, BM; Parks, M; Goate, A; Raj, T;
    2020;  
    PLoS genetics;  
    Volume: 16;  
    Issue: 2;  
    DOI: 10.1371/journal.pgen.1008549

  161. Overlapping genetic architecture between Parkinson disease and melanoma

    Dube, U; Ibanez, L; Budde, JP; Benitez, BA; Davis, AA; Harari, O; Iles, MM; Law, MH; Brown, KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
    Issue: 2;  
    DOI: 10.1007/s00401-019-02110-z

  162. Innate sensing of mechanical properties of brain tissue by microglia

    Ayata, P; Schaefer, A;
    2020;  
    Current Opinion in Immunology;  
    Volume: 62;  
    DOI: 10.1016/j.coi.2020.01.003

  163. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

    Li, Z; Farias, FHG; Dube, U; Del-Aguila, JL; Mihindukulasuriya, KA; Fernandez, MV; Ibanez, L; Budde, JP; Wang, F; Lake, AM; Deming, Y; Perez, J; Yang, C; Bahena, JA; Qin, W; Bradley, JL; Davenport, R; Bergmann, K; Morris, JC; Perrin, RJ; Benitez, BA; Dougherty, JD; Harari, O; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
    Issue: 1;  
    DOI: 10.1007/s00401-019-02066-0

  164. Linking depressive symptoms and cognitive functioning: The mediating role of leisure activity

    Sharifian, N; Gu, Y; Manly, JJ; Schupf, N; Mayeux, R; Brickman, AM; Zahodne, LB;
    2020;  
    Neuropsychology;  
    Volume: 34;  
    Issue: 1;  
    DOI: 10.1037/neu0000595

  165. Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity

    Vardarajan, B; Kalia, V; Manly, J; Brickman, A; Reyes-Dumeyer, D; Lantigua, R; Ionita-Laza, I; Jones, DP; Miller, GW; Mayeux, R;
    2020;  
    Alzheimer's & Dementia (New York, N. Y.);  
    Volume: 6;  
    Issue: 1;  
    DOI: 10.1002/trc2.12025

  166. APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults

    Turney, IC; Chesebro, AG; Rentería, MA; Lao, PJ; Beato, JM; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 12;  
    Issue: 1;  
    DOI: 10.1002/dad2.12094

  167. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

    Faura, J; Bustamante, A; Penalba, A; Giralt, D; Simats, A; Martínez-Sáez, E; Alcolea, D; Fortea, J; Lleó, A; Teunissen, CE; van der Flier, WM; Ibañez, L; Harari, O; Cruchaga, C; Hernández-Guillamón, M; Delgado, P; Montaner, J;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 73;  
    Issue: 4;  
    DOI: 10.3233/JAD-190753

  168. Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning

    Stojanovic, M; Jin, Y; Fagan, AM; Benzinger, TL; Hassenstab, J; Cruchaga, C; Morris, JC; Head, D;
    2020;  
    Alzheimer Disease and Associated Disorders;  
    Volume: 34;  
    Issue: 3;  
    DOI: 10.1097/WAD.0000000000000385

  169. Reproducibility of serum cytokines in an elderly population

    Guo, J; Schupf, N; Mayeux, RP; Gu, Y;
    2020;  
    Immunity & Ageing: I & A;  
    Volume: 17;  
    DOI: 10.1186/s12979-020-00201-0

  170. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes

    Olive, C; Ibanez, L; Farias, FHG; Wang, F; Budde, JP; Norton, JB; Gentsch, J; Morris, JC; Li, Z; Dube, U; Del-Aguila, J; Bergmann, K; Bradley, J; Benitez, BA; Harari, O; Fagan, A; Ances, B; Cruchaga, C; Fernandez, MV;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 77;  
    Issue: 4;  
    DOI: 10.3233/JAD-200019

  171. Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease

    Aschenbrenner, AJ; Gordon, BA; Fagan, AM; Schindler, SE; Balota, DA; Morris, JC; Hassenstab, JJ;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 74;  
    Issue: 4;  
    DOI: 10.3233/JAD-200018

    172. 2019

  172. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

    Dube, U; Del-Aguila, JL; Li, Z; Budde, JP; Jiang, S; Hsu, S; Ibanez, L; Fernandez, MV; Farias, F; Norton, J; Gentsch, J; Wang, F; Dominantly Inherited Alzheimer Network (DIAN); Salloway, S; Masters, CL; Lee, J; Graff-Radford, NR; Chhatwal, JP; Bateman, RJ; Morris, JC; Karch, CM; Harari, O; Cruchaga, C;
    2019;  
    Nature Neuroscience;  
    Volume: 22;  
    Issue: 11;  
    DOI: 10.1038/s41593-019-0501-5

  173. Sex differences in the genetic predictors of Alzheimer's pathology

    Dumitrescu, L; Barnes, LL; Thambisetty, M; Beecham, G; Kunkle, B; Bush, WS; Gifford, KA; Chibnik, LB; Mukherjee, S; De Jager, PL; Kukull, W; Crane, PK; Resnick, SM; Keene, CD; Montine, TJ; Schellenberg, GD; Deming, Y; Chao, MJ; Huentelman, M; Martin, ER; Hamilton-Nelson, K; Shaw, LM; Trojanowski, JQ; Peskind, ER; Cruchaga, C; Pericak-Vance, MA; Goate, AM; Cox, NJ; Haines, JL; Zetterberg, H; Blennow, K; Larson, EB; Johnson, SC; Albert, M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative; Bennett, DA; Schneider, JA; Jefferson, AL; Hohman, TJ;
    2019;  
    Brain: A Journal of Neurology;  
    Volume: 142;  
    Issue: 9;  
    DOI: 10.1093/brain/awz206

  174. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

    Ewers, M; Franzmeier, N; Suárez-Calvet, M; Morenas-Rodriguez, E; Caballero, MAA; Kleinberger, G; Piccio, L; Cruchaga, C; Deming, Y; Dichgans, M; Trojanowski, JQ; Shaw, LM; Weiner, MW; Haass, C; Alzheimer’s Disease Neuroimaging Initiative;
    2019;  
    Science Translational Medicine;  
    Volume: 11;  
    Issue: 507;  
    DOI: 10.1126/scitranslmed.aav6221

  175. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

    Deming, Y; Filipello, F; Cignarella, F; Cantoni, C; Hsu, S; Mikesell, R; Li, Z; Del-Aguila, JL; Dube, U; Farias, FG; Bradley, J; Budde, J; Ibanez, L; Fernandez, MV; Blennow, K; Zetterberg, H; Heslegrave, A; Johansson, PM; Svensson, J; Nellgård, B; Lleo, A; Alcolea, D; Clarimon, J; Rami, L; Molinuevo, JL; Suárez-Calvet, M; Morenas-Rodríguez, E; Kleinberger, G; Ewers, M; Harari, O; Haass, C; Brett, TJ; Benitez, BA; Karch, CM; Piccio, L; Cruchaga, C;
    2019;  
    Science Translational Medicine;  
    Volume: 11;  
    Issue: 505;  
    DOI: 10.1126/scitranslmed.aau2291

  176. A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

    Del-Aguila, JL; Li, Z; Dube, U; Mihindukulasuriya, KA; Budde, JP; Fernandez, MV; Ibanez, L; Bradley, J; Wang, F; Bergmann, K; Davenport, R; Morris, JC; Holtzman, DM; Perrin, RJ; Benitez, BA; Dougherty, J; Cruchaga, C; Harari, O;
    2019;  
    Alzheimer's Research & Therapy;  
    Volume: 11;  
    Issue: 1;  
    DOI: 10.1186/s13195-019-0524-x

  177. TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

    Del-Aguila, JL; Benitez, BA; Li, Z; Dube, U; Mihindukulasuriya, KA; Budde, JP; Farias, FHG; Fernández, MV; Ibanez, L; Jiang, S; Perrin, RJ; Cairns, NJ; Morris, JC; Harari, O; Cruchaga, C;
    2019;  
    Molecular Neurodegeneration;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13024-019-0319-3

  178. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

    Zhang, X; Zhu, C; Beecham, G; Vardarajan, BN; Ma, Y; Lancour, D; Farrell, JJ; Chung, J; Alzheimer's Disease Sequencing Project; Mayeux, R; Haines, JL; Schellenberg, GD; Pericak-Vance, MA; Lunetta, KL; Farrer, LA;
    2019;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 15;  
    Issue: 3;  
    DOI: 10.1016/j.jalz.2018.10.005

  179. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    2019;  
    Nature Genetics;  
    Volume: 51;  
    Issue: 3;  
    DOI: 10.1038/s41588-019-0358-2

  180. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

    Kapoor, M; Wang, J; Farris, SP; Liu, Y; McClintick, J; Gupta, I; Meyers, JL; Bertelsen, S; Chao, M; Nurnberger, J; Tischfield, J; Harari, O; Zeran, L; Hesselbrock, V; Bauer, L; Raj, T; Porjesz, B; Agrawal, A; Foroud, T; Edenberg, HJ; Mayfield, RD; Goate, A;
    2019;  
    Translational Psychiatry;  
    Volume: 9;  
    Issue: 1;  
    DOI: 10.1038/s41398-019-0384-y

  181. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

    2019;  
    Molecular Neurodegeneration;  
    Volume: 14;  
    Issue: 1;  
    DOI: 10.1186/s13024-018-0301-5

  182. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease

    Baker, E; Sims, R; Leonenko, G; Frizzati, A; Harwood, JC; Grozeva, D; GERAD/PERADES; CHARGE; ADGC; EADI; IGAP consortia; Morgan, K; Passmore, P; Holmes, C; Powell, J; Brayne, C; Gill, M; Mead, S; Bossù, P; Spalletta, G; Goate, AM; Cruchaga, C; Maier, W; Heun, R; Jessen, F; Peters, O; Dichgans, M; FröLich, L; Ramirez, A; Jones, L; Hardy, J; Ivanov, D; Hill, M; Holmans, P; Allen, ND; Morgan, BP; Seshadri, S; Schellenberg, GD; Amouyel, P; Williams, J; Escott-Price, V;
    2019;  
    PloS One;  
    Volume: 14;  
    Issue: 7;  
    DOI: 10.1371/journal.pone.0218111

    183. 2018

  183. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

    Jiang, S; Wen, N; Li, Z; Dube, U; Del Aguila, J; Budde, J; Martinez, R; Hsu, S; Fernandez, MV; Cairns, NJ; Dominantly Inherited Alzheimer Network (DIAN); International FTD-Genomics Consortium (IFGC); Harari, O; Cruchaga, C; Karch, CM;
    2018;  
    Translational Psychiatry;  
    Volume: 8;  
    Issue: 1;  
    DOI: 10.1038/s41398-018-0319-z

  184. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease

    Beecham, GW; Vardarajan, B; Blue, E; Bush, W; Jaworski, J; Barral, S; DeStefano, A; Hamilton-Nelson, K; Kunkle, B; Martin, ER; Naj, A; Rajabli, F; Reitz, C; Thornton, T; van Duijn, C; Goate, A; Seshadri, S; Farrer, LA; Boerwinkle, E; Schellenberg, G; Haines, JL; Wijsman, E; Mayeux, R; Pericak-Vance, MA; Alzheimer's Disease Sequencing Project;
    2018;  
    Neurology. Genetics;  
    Volume: 4;  
    Issue: 6;  
    DOI: 10.1212/NXG.0000000000000286

  185. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

    2018;  
    EMBO molecular medicine;  
    Volume: 10;  
    Issue: 12;  
    DOI: 10.15252/emmm.201809712

  186. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

    Rathore, N; Ramani, SR; Pantua, H; Payandeh, J; Bhangale, T; Wuster, A; Kapoor, M; Sun, Y; Kapadia, SB; Gonzalez, L; Zarrin, AA; Goate, A; Hansen, DV; Behrens, TW; Graham, RR;
    2018;  
    PLoS genetics;  
    Volume: 14;  
    Issue: 11;  
    DOI: 10.1371/journal.pgen.1007427

  187. Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

    Deming, Y; Li, Z; Benitez, BA; Cruchaga, C;
    2018;  
    Expert Opinion on Therapeutic Targets;  
    Volume: 22;  
    Issue: 7;  
    DOI: 10.1080/14728222.2018.1486823