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    2024

  1. 2024;  
    Trends in Molecular Medicine;  
    Volume: 30;  
    Issue: 10;  
  2. A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice

    Lu, S; Di John Portela, I; Martino, N; Bossardi Ramos, R; Salinero, AE; Smith, RM; Zuloaga, KL; Adam, AP;
    2024;  
    Neuroscience;  
    Volume: 555;  
  3. 2024;  
    PLoS computational biology;  
    Volume: 20;  
    Issue: 9;  
  4. 2024;  
    Environmental Health Perspectives;  
    Volume: 132;  
    Issue: 9;  
  5. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

    Kloske, CM; Belloy, ME; Blue, EE; Bowman, GR; Carrillo, MC; Chen, X; Chiba-Falek, O; Davis, AA; Paolo, GD; Garretti, F; Gate, D; Golden, LR; Heinecke, JW; Herz, J; Huang, Y; Iadecola, C; Johnson, LA; Kanekiyo, T; Karch, CM; Khvorova, A; Koppes-den Hertog, SJ; Lamb, BT; Lawler, PE; Guen, YL; Litvinchuk, A; Liu, C; Mahinrad, S; Marcora, E; Marino, C; Michaelson, DM; Miller, JJ; Morganti, JM; Narayan, PS; Naslavsky, MS; Oosthoek, M; Ramachandran, KV; Ramakrishnan, A; Raulin, A; Robert, A; Saleh, RNM; Sexton, C; Shah, N; Shue, F; Sible, IJ; Soranno, A; Strickland, MR; Tcw, J; Thierry, M; Tsai, L; Tuckey, RA; Ulrich, JD; van der Kant, R; Wang, N; Wellington, CL; Weninger, SC; Yassine, HN; Zhao, N; Bu, G; Goate, AM; Holtzman, DM;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 9;  
  6. 2024;  
    Aging Cell;  
    Volume: 23;  
    Issue: 9;  
  7. A genetic and proteomic comparison of key AD biomarkers across tissues

    Marsh, TW; Western, D; Timsina, J; Gorijala, P; Yang, C; Pastor, P; Liu, M; Morris, JC; Bateman, RJ; Schindler, SE; Sung, YJ; Dominantly Inherited Alzheimer Network; Cruchaga, C;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 9;  
  8. Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups

    Ma, Y; Reyes-Dumeyer, D; Piriz, A; Recio, P; Mejia, DR; Medrano, M; Lantigua, RA; Vonsattel, JPG; Tosto, G; Teich, AF; Ciener, B; Leskinen, S; Sivakumar, S; DeTure, M; Ranjan, D; Dickson, D; Murray, M; Lee, E; Wolk, DA; Jin, L; Dugger, BN; Hiniker, A; Rissman, RA; Mayeux, R; Vardarajan, BN;
    2024;  
    Acta Neuropathologica;  
    Volume: 148;  
    Issue: 1;  
  9. Effects of high fat diet on metabolic health vary by age of menopause onset

    Salinero, AE; Venkataganesh, H; Abi-Ghanem, C; Riccio, D; Kelly, RD; Gannon, OJ; Sura, A; Brooks, HL; Zuloaga, DG; Zuloaga, KL;
    2024;  
    International Journal of Obesity (2005);  
  10. Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice

    Salinero, AE; Abi-Ghanem, C; Venkataganesh, H; Sura, A; Smith, RM; Thrasher, CA; Kelly, RD; Hatcher, KM; NyBlom, V; Shamlian, V; Kyaw, N; Belanger, KM; Gannon, OJ; Stephens, SBZ; Zuloaga, DG; Zuloaga, KL;
    2024;  
    Hormones and Behavior;  
    Volume: 164;  
  11. Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry

    Ray, NR; Kunkle, BW; Hamilton-Nelson, K; Kurup, JT; Rajabli, F; Qiao, M; Vardarajan, BN; Cosacak, MI; Kizil, C; Jean-Francois, M; Cuccaro, M; Reyes-Dumeyer, D; Cantwell, L; Kuzma, A; Vance, JM; Gao, S; Hendrie, HC; Baiyewu, O; Ogunniyi, A; Akinyemi, RO; Alzheimer's Disease Genetics Consortium; Lee, W; Martin, ER; Wang, L; Beecham, GW; Bush, WS; Xu, W; Jin, F; Wang, L; Farrer, LA; Haines, JL; Byrd, GS; Schellenberg, GD; Mayeux, R; Pericak-Vance, MA; Reitz, C;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 8;  
  12. High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

    Lai, Y; Koelmel, JP; Walker, DI; Price, EJ; Papazian, S; Manz, KE; Castilla-Fernández, D; Bowden, JA; Nikiforov, V; David, A; Bessonneau, V; Amer, B; Seethapathy, S; Hu, X; Lin, EZ; Jbebli, A; McNeil, BR; Barupal, D; Cerasa, M; Xie, H; Kalia, V; Nandakumar, R; Singh, R; Tian, Z; Gao, P; Zhao, Y; Froment, J; Rostkowski, P; Dubey, S; Coufalíková, K; Seličová, H; Hecht, H; Liu, S; Udhani, HH; Restituito, S; Tchou-Wong, K; Lu, K; Martin, JW; Warth, B; Godri Pollitt, KJ; Klánová, J; Fiehn, O; Metz, TO; Pennell, KD; Jones, DP; Miller, GW;
    2024;  
    Environmental Science & Technology;  
    Volume: 58;  
    Issue: 29;  
  13. Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease

    McDade, E; Liu, H; Bui, Q; Hassenstab, J; Gordon, B; Benzinger, T; Shen, Y; Timsina, J; Wang, L; Sung, YJ; Karch, C; Renton, A; Daniels, A; Morris, J; Xiong, C; Ibanez, L; Perrin, R; Llibre-Guerra, JJ; Day, G; Supnet-Bell, C; Xu, X; Berman, S; Chhatwal, J; Ikeuchi, T; Kasuga, K; Niimi, Y; Huey, E; Schofield, P; Brooks, W; Ryan, N; Jucker, M; Laske, C; Levin, J; Vöglein, J; Roh, JH; Lopera, F; Bateman, R; Cruchaga, C;
    2024;  
    Research Square;  
  14. European and African-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites

    Cruchaga, C; Yang, C; Gorijala, P; Timsina, J; Wang, L; Liu, M; Wang, C; Brock, W; Wang, Y; Sung, YJ;
    2024;  
    Research Square;  
  15. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

    Debette, S; Caro, I; Western, D; Namba, S; Sun, N; Kawaguchi, S; He, Y; Fujita, M; Roshchupkin, G; D'Aoust, T; Duperron, M; Sargurupremraj, M; Tsuchida, A; Koido, M; Ahmadi, M; Yang, C; Timsina, J; Ibanez, L; Matsuda, K; Suzuki, Y; Oda, Y; Kanai, A; Jandaghi, P; Munter, HM; Auld, D; Astafeva, I; Puerta, R; Rotter, J; Psaty, B; Bis, J; Longstreth, W; Couffinhal, T; Garcia-Gonzalez, P; Pytel, V; Marquié, M; Cano, A; Boada, M; Joliot, M; Lathrop, M; Le Grand, Q; Launer, L; Wardlaw, J; Heiman, M; Ruiz, A; Matthews, P; Seshadri, S; Fornage, M; Adams, H; Mishra, A; Trégouët, D; Okada, Y; Kellis, M; De Jager, P; Tzourio, C; Kamatani, Y; Matsuda, F; Cruchaga, C;
    2024;  
    Research Square;  
  16. Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3

    Panyard, DJ; Reus, LM; Ali, M; Liu, J; Deming, YK; Lu, Q; Kollmorgen, G; Carboni, M; Wild, N; Visser, PJ; Bertram, L; Zetterberg, H; Blennow, K; Gobom, J; Western, D; Sung, YJ; Carlsson, CM; Johnson, SC; Asthana, S; Cruchaga, C; Tijms, BM; Engelman, CD; Snyder, MP;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 7;  
  17. Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction

    İş, Ö; Wang, X; Reddy, JS; Min, Y; Yilmaz, E; Bhattarai, P; Patel, T; Bergman, J; Quicksall, Z; Heckman, MG; Tutor-New, FQ; Can Demirdogen, B; White, L; Koga, S; Krause, V; Inoue, Y; Kanekiyo, T; Cosacak, MI; Nelson, N; Lee, AJ; Vardarajan, B; Mayeux, R; Kouri, N; Deniz, K; Carnwath, T; Oatman, SR; Lewis-Tuffin, LJ; Nguyen, T; Alzheimer’s Disease Neuroimaging Initiative; Carrasquillo, MM; Graff-Radford, J; Petersen, RC; Jr Jack, CR; Kantarci, K; Murray, ME; Nho, K; Saykin, AJ; Dickson, DW; Kizil, C; Allen, M; Ertekin-Taner, N;
    2024;  
    Nature Communications;  
    Volume: 15;  
    Issue: 1;  
  18. 2024;  
    Hormones and Behavior;  
    Volume: 162;  
  19. TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma

    Yi, H; Yang, Q; Repaci, C; Lee, CM; Heo, G; Timsina, J; Gorijala, P; Yang, C; Budde, J; Wang, L; Cruchaga, C; Sung, YJ;
    2024;  
    Scientific Data;  
    Volume: 11;  
    Issue: 1;  
  20. Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease

    Bhattarai, P; Gunasekaran, TI; Belloy, ME; Reyes-Dumeyer, D; Jülich, D; Tayran, H; Yilmaz, E; Flaherty, D; Turgutalp, B; Sukumar, G; Alba, C; McGrath, EM; Hupalo, DN; Bacikova, D; Le Guen, Y; Lantigua, R; Medrano, M; Rivera, D; Recio, P; Nuriel, T; Ertekin-Taner, N; Teich, AF; Dickson, DW; Holley, S; Greicius, M; Dalgard, CL; Zody, M; Mayeux, R; Kizil, C; Vardarajan, BN;
    2024;  
    Acta Neuropathologica;  
    Volume: 147;  
    Issue: 1;  
  21. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain

    Fujita, M; Gao, Z; Zeng, L; McCabe, C; White, CC; Ng, B; Green, GS; Rozenblatt-Rosen, O; Phillips, D; Amir-Zilberstein, L; Lee, H; Pearse, RV; Khan, A; Vardarajan, BN; Kiryluk, K; Ye, CJ; Klein, H; Wang, G; Regev, A; Habib, N; Schneider, JA; Wang, Y; Young-Pearse, T; Mostafavi, S; Bennett, DA; Menon, V; De Jager, PL;
    2024;  
    Nature Genetics;  
    Volume: 56;  
    Issue: 4;  
  22. Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease

    Eteleeb, AM; Novotny, BC; Tarraga, CS; Sohn, C; Dhungel, E; Brase, L; Nallapu, A; Buss, J; Farias, F; Bergmann, K; Bradley, J; Norton, J; Gentsch, J; Wang, F; Davis, AA; Morris, JC; Karch, CM; Perrin, RJ; Benitez, BA; Harari, O;
    2024;  
    PLoS biology;  
    Volume: 22;  
    Issue: 4;  
  23. BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

    Podleśny-Drabiniok, A; Novikova, G; Liu, Y; Dunst, J; Temizer, R; Giannarelli, C; Marro, S; Kreslavsky, T; Marcora, E; Goate, AM;
    2024;  
    Nature Communications;  
    Volume: 15;  
    Issue: 1;  
  24. Risk of Alzheimer's disease is associated with longitudinal changes in plasma biomarkers in the multi-ethnic Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP) cohort

    Gu, Y; Honig, LS; Kang, MS; Bahl, A; Sanchez, D; Reyes-Dumeyer, D; Manly, JJ; Dage, JL; Lantigua, RA; Brickman, AM; Vardarajan, BN; Mayeux, R;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 3;  
  25. Data-Independent Acquisition and Label-Free Quantification for Quantitative Proteomics Analysis of Human Cerebrospinal Fluid

    Makepeace, KAT; Rookyard, AW; Das, L; Vardarajan, BN; Chakrabarty, JK; Jain, A; Kang, MS; Werth, EG; Reyes-Dumeyer, D; Zerlin-Esteves, M; Honig, LS; Mayeux, R; Brown, LM;
    2024;  
    Current Protocols;  
    Volume: 4;  
    Issue: 3;  
  26. Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging

    Rubinstein, T; Brickman, AM; Cheng, B; Burkett, S; Park, H; Annavajhala, MK; Uhlemann, A; Andrews, H; Gutierrez, J; Paster, BJ; Noble, JM; Papapanou, PN;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 3;  
  27. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease

    Archer, DB; Eissman, JM; Mukherjee, S; Lee, ML; Choi, S; Scollard, P; Trittschuh, EH; Mez, JB; Bush, WS; Kunkle, BW; Naj, AC; Gifford, KA; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer's Disease Genetics Consortium (ADGC); Alzheimer's Disease Sequencing Project (ADSP); Cuccaro, ML; Pericak-Vance, MA; Farrer, LA; Wang, L; Schellenberg, GD; Mayeux, RP; Haines, JL; Jefferson, AL; Kukull, WA; Keene, CD; Saykin, AJ; Thompson, PM; Martin, ER; Bennett, DA; Barnes, LL; Schneider, JA; Crane, PK; Dumitrescu, L; Hohman, TJ;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 2;  
  28. Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

    Gorijala, P; Aslam, MM; Dang, LT; Xicota, L; Fernandez, MV; Sung, YJ; Fan, K; Feingold, E; Surace, EI; Chhatwal, JP; Hom, CL; Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI); NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators; Hartley, SL; Hassenstab, J; Perrin, RJ; Mapstone, M; Zaman, SH; Ances, BM; Kamboh, MI; Lee, JH; Cruchaga, C;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 2;  
  29. OXR1 maintains the retromer to delay brain aging under dietary restriction

    Wilson, KA; Bar, S; Dammer, EB; Carrera, EM; Hodge, BA; Hilsabeck, TAU; Bons, J; Brownridge, GW; Beck, JN; Rose, J; Granath-Panelo, M; Nelson, CS; Qi, G; Gerencser, AA; Lan, J; Afenjar, A; Chawla, G; Brem, RB; Campeau, PM; Bellen, HJ; Schilling, B; Seyfried, NT; Ellerby, LM; Kapahi, P;
    2024;  
    Nature Communications;  
    Volume: 15;  
    Issue: 1;  
  30. Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease

    Wang, L; Nykänen, N; Western, D; Gorijala, P; Timsina, J; Li, F; Wang, Z; Ali, M; Yang, C; Liu, M; Brock, W; Marquié, M; Boada, M; Alvarez, I; Aguilar, M; Pastor, P; Ruiz, A; Puerta, R; Orellana, A; Rutledge, J; Oh, H; Greicius, MD; Le Guen, Y; Perrin, RJ; Wyss-Coray, T; Jefferson, A; Hohman, TJ; Graff-Radford, N; Mori, H; Goate, A; Levin, J; Sung, YJ; Cruchaga, C;
    2024;  
    Molecular Neurodegeneration;  
    Volume: 19;  
    Issue: 1;  
  31. DNA from multiple viral species is associated with Alzheimer's disease risk

    Tejeda, M; Farrell, J; Zhu, C; Wetzler, L; Lunetta, KL; Bush, WS; Martin, ER; Wang, L; Schellenberg, GD; Pericak-Vance, MA; Haines, JL; Farrer, LA; Sherva, R;
    2024;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 20;  
    Issue: 1;  
  32. Effect of altered production and storage of dopamine on development and behavior in C. elegans

    Lee, I; Knickerbocker, AC; Depew, CR; Martin, EL; Dicent, J; Miller, GW; Bucher, ML;
    2024;  
    Frontiers in Toxicology;  
    Volume: 6;  
  33. 2023

  34. A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis

    Zeng, L; Fujita, M; Gao, Z; White, CC; Green, GS; Habib, N; Menon, V; Bennett, DA; Boyle, P; Klein, H; De Jager, PL;
    2023;  
    Biological Psychiatry;  
  35. Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions

    Kim, SC; Mitchell, SJ; Qamar, S; Whitcomb, DJ; Ruepp, M; St George-Hyslop, P; Cho, K;
    2023;  
    Acta Neuropathologica Communications;  
    Volume: 11;  
    Issue: 1;  
  36. Cell-free RNA signatures predict Alzheimer's disease

    Cisterna-García, A; Beric, A; Ali, M; Pardo, JA; Chen, H; Fernandez, MV; Norton, J; Gentsch, J; Bergmann, K; Budde, J; Perlmutter, JS; Morris, JC; Cruchaga, C; Botia, JA; Ibanez, L;
    2023;  
    iScience;  
    Volume: 26;  
    Issue: 12;  
  37. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews

    Li, D; Farrell, JJ; Mez, J; Martin, ER; Bush, WS; Ruiz, A; Boada, M; de Rojas, I; Mayeux, R; Haines, JL; Vance, MAP; Wang, L; Schellenberg, GD; Lunetta, KL; Farrer, LA;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 12;  
  38. 2023;  
    Molecular Neurodegeneration;  
    Volume: 18;  
    Issue: 1;  
  39. INPP5D regulates inflammasome activation in human microglia

    Chou, V; Pearse, RV; Aylward, AJ; Ashour, N; Taga, M; Terzioglu, G; Fujita, M; Fancher, SB; Sigalov, A; Benoit, CR; Lee, H; Lam, M; Seyfried, NT; Bennett, DA; De Jager, PL; Menon, V; Young-Pearse, TL;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  40. Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene

    Yu, C; Bakshi, A; Watts, GF; Renton, AE; Fulton-Howard, B; Goate, AM; Natarajan, P; Chasman, DI; Robman, L; Woods, RL; Guymer, R; Wolfe, R; Thao, LTP; McNeil, JJ; Tonkin, AM; Nicholls, SJ; Lacaze, P;
    2023;  
    Journal of the American Heart Association;  
    Volume: 12;  
    Issue: 21;  
  41. Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning

    Neumann, A; Ohlei, O; Küçükali, F; Bos, IJ; Timsina, J; Vos, S; Prokopenko, D; Tijms, BM; Andreasson, U; Blennow, K; Vandenberghe, R; Scheltens, P; Teunissen, CE; Engelborghs, S; Frisoni, GB; Blin, O; Richardson, JC; Bordet, R; Lleó, A; Alcolea, D; Popp, J; Marsh, TW; Gorijala, P; Clark, C; Peyratout, G; Martinez-Lage, P; Tainta, M; Dobson, RJB; Legido-Quigley, C; Van Broeckhoven, C; Tanzi, RE; Ten Kate, M; Lill, CM; Barkhof, F; Cruchaga, C; Lovestone, S; Streffer, J; Zetterberg, H; Visser, PJ; Sleegers, K; Bertram, L; EMIF-AD & ADNI study group;
    2023;  
    Genome Medicine;  
    Volume: 15;  
    Issue: 1;  
  42. Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways

    Webber, CJ; Murphy, CN; Rondón-Ortiz, AN; van der Spek, SJF; Kelly, EX; Lampl, NM; Chiesa, G; Khalil, AS; Emili, A; Wolozin, B;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 20;  
  43. 2023;  
    Briefings in Bioinformatics;  
    Volume: 24;  
    Issue: 6;  
  44. Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM

    O'Neill, NK; Stein, TD; Hu, J; Rehman, H; Campbell, JD; Yajima, M; Zhang, X; Farrer, LA;
    2023;  
    BMC bioinformatics;  
    Volume: 24;  
    Issue: 1;  
  45. Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

    Weng, C; Gu, A; Zhang, S; Lu, L; Ke, L; Gao, P; Liu, X; Wang, Y; Hu, P; Plummer, D; MacDonald, E; Zhang, S; Xi, J; Lai, S; Leskov, K; Yuan, K; Jin, F; Li, Y;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  46. The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology

    Ray, NR; Ayodele, T; Jean-Francois, M; Baez, P; Fernandez, V; Bradley, J; Crane, PK; Dalgard, CL; Kuzma, A; Nicaretta, H; Sims, R; Williams, J; Cuccaro, ML; Pericak-Vance, MA; Mayeux, R; Wang, L; Schellenberg, GD; Cruchaga, C; Beecham, GW; Reitz, C;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 9;  
  47. Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk

    Celis, K; Moreno, MDMM; Rajabli, F; Whitehead, P; Hamilton-Nelson, K; Dykxhoorn, DM; Nuytemans, K; Wang, L; Flanagan, M; Weintraub, S; Geula, C; Gearing, M; Dalgard, CL; Jin, F; Bennett, DA; Schuck, T; Pericak-Vance, MA; Griswold, AJ; Young, JI; Vance, JM;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 9;  
  48. Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells

    Bertucci, T; Kakarla, S; Winkelman, MA; Lane, K; Stevens, K; Lotz, S; Grath, A; James, D; Temple, S; Dai, G;
    2023;  
    APL bioengineering;  
    Volume: 7;  
    Issue: 3;  
  49. Effects of Vascular Risk Factors on the Association of Blood-Based Biomarkers with Alzheimer's Disease

    Hoost, SS; Brickman, AM; Manly, JJ; Honig, LS; Gu, Y; Sanchez, D; Reyes-Dumeyer, D; Lantigua, RA; Kang, MS; Dage, JL; Mayeux, R;
    2023;  
    Medical Research Archives;  
    Volume: 11;  
    Issue: 9;  
  50. Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions

    Park, J; Wu, Y; Shao, W; Gendron, TF; van der Spek, SJF; Sultanakhmetov, G; Basu, A; Castellanos Otero, P; Jones, CJ; Jansen-West, K; Daughrity, LM; Phanse, S; Del Rosso, G; Tong, J; Castanedes-Casey, M; Jiang, L; Libera, J; Oskarsson, B; Dickson, DW; Sanders, DW; Brangwynne, CP; Emili, A; Wolozin, B; Petrucelli, L; Zhang, Y;
    2023;  
    Cell Reports;  
    Volume: 42;  
    Issue: 8;  
  51. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1

    Lee, H; Aylward, AJ; Pearse, RV; Lish, AM; Hsieh, Y; Augur, ZM; Benoit, CR; Chou, V; Knupp, A; Pan, C; Goberdhan, S; Duong, DM; Seyfried, NT; Bennett, DA; Taga, MF; Huynh, K; Arnold, M; Meikle, PJ; De Jager, PL; Menon, V; Young, JE; Young-Pearse, TL;
    2023;  
    Cell Reports;  
    Volume: 42;  
    Issue: 8;  
  52. Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

    Nutma, E; Fancy, N; Weinert, M; Tsartsalis, S; Marzin, MC; Muirhead, RCJ; Falk, I; Breur, M; de Bruin, J; Hollaus, D; Pieterman, R; Anink, J; Story, D; Chandran, S; Tang, J; Trolese, MC; Saito, T; Saido, TC; Wiltshire, KH; Beltran-Lobo, P; Phillips, A; Antel, J; Healy, L; Dorion, M; Galloway, DA; Benoit, RY; Amossé, Q; Ceyzériat, K; Badina, AM; Kövari, E; Bendotti, C; Aronica, E; Radulescu, CI; Wong, JH; Barron, AM; Smith, AM; Barnes, SJ; Hampton, DW; van der Valk, P; Jacobson, S; Howell, OW; Baker, D; Kipp, M; Kaddatz, H; Tournier, BB; Millet, P; Matthews, PM; Moore, CS; Amor, S; Owen, DR;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  53. Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature

    Berson, E; Sreenivas, A; Phongpreecha, T; Perna, A; Grandi, FC; Xue, L; Ravindra, NG; Payrovnaziri, N; Mataraso, S; Kim, Y; Espinosa, C; Chang, AL; Becker, M; Montine, KS; Fox, EJ; Chang, HY; Corces, MR; Aghaeepour, N; Montine, TJ;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  54. The liquid-to-solid transition of FUS is promoted by the condensate surface

    Shen, Y; Chen, A; Wang, W; Shen, Y; Ruggeri, FS; Aime, S; Wang, Z; Qamar, S; Espinosa, JR; Garaizar, A; St George-Hyslop, P; Collepardo-Guevara, R; Weitz, DA; Vigolo, D; Knowles, TPJ;
    2023;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 120;  
    Issue: 33;  
  55. Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease

    Robison, LS; Gannon, OJ; Salinero, AE; Abi-Ghanem, C; Kelly, RD; Riccio, DA; Mansour, FM; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
  56. An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology

    Sheehan, PW; Nadarajah, CJ; Kanan, MF; Patterson, JN; Novotny, B; Lawrence, JH; King, MW; Brase, L; Inman, CE; Yuede, CM; Lee, J; Patel, TK; Harari, O; Benitez, BA; Davis, AA; Musiek, ES;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 15;  
  57. Genetic architecture of plasma Alzheimer disease biomarkers

    Bradley, J; Gorijala, P; Schindler, SE; Sung, YJ; Ances, B; Alzheimer’s Disease Neuroimaging Initiative, the Human Connectome Project; Fernandez, MV; Cruchaga, C;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 15;  
  58. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease

    Phillips, B; Western, D; Wang, L; Timsina, J; Sun, Y; Gorijala, P; Yang, C; Do, A; Nykänen, N; Alvarez, I; Aguilar, M; Pastor, P; Morris, JC; Schindler, SE; Fagan, AM; Puerta, R; García-González, P; de Rojas, I; Marquié, M; Boada, M; Ruiz, A; Perlmutter, JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez, L; Perrin, RJ; Sung, YJ; Cruchaga, C;
    2023;  
    NPJ Parkinson's disease;  
    Volume: 9;  
    Issue: 1;  
  59. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease

    Sung, YJ; Yang, C; Norton, J; Johnson, M; Fagan, A; Bateman, RJ; Perrin, RJ; Morris, JC; Farlow, MR; Chhatwal, JP; Schofield, PR; Chui, H; Wang, F; Novotny, B; Eteleeb, A; Karch, C; Schindler, SE; Rhinn, H; Johnson, ECB; Oh, HS; Rutledge, JE; Dammer, EB; Seyfried, NT; Wyss-Coray, T; Harari, O; Cruchaga, C;
    2023;  
    Science Translational Medicine;  
    Volume: 15;  
    Issue: 703;  
  60. Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy

    Zhao, J; Jiang, L; Matlock, A; Xu, Y; Zhu, J; Zhu, H; Tian, L; Wolozin, B; Cheng, J;
    2023;  
    Light, Science & Applications;  
    Volume: 12;  
    Issue: 1;  
  61. Autolysosomal exocytosis of lipids protect neurons from ferroptosis

    Ralhan, I; Chang, J; Moulton, MJ; Goodman, LD; Lee, NYJ; Plummer, G; Pasolli, HA; Matthies, D; Bellen, HJ; Ioannou, MS;
    2023;  
    The Journal of Cell Biology;  
    Volume: 222;  
    Issue: 6;  
  62. APOE and immunity: Research highlights

    Kloske, CM; Barnum, CJ; Batista, AF; Bradshaw, EM; Brickman, AM; Bu, G; Dennison, J; Gearon, MD; Goate, AM; Haass, C; Heneka, MT; Hu, WT; Huggins, LKL; Jones, NS; Koldamova, R; Lemere, CA; Liddelow, SA; Marcora, E; Marsh, SE; Nielsen, HM; Petersen, KK; Petersen, M; Piña-Escudero, SD; Qiu, WQ; Quiroz, YT; Reiman, E; Sexton, C; Tansey, MG; Tcw, J; Teunissen, CE; Tijms, BM; van der Kant, R; Wallings, R; Weninger, SC; Wharton, W; Wilcock, DM; Wishard, TJ; Worley, SL; Zetterberg, H; Carrillo, MC;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 6;  
  63. 2023;  
    Trends in Neurosciences;  
    Volume: 46;  
    Issue: 6;  
  64. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

    Filipello, F; You, S; Mirfakhar, FS; Mahali, S; Bollman, B; Acquarone, M; Korvatska, O; Marsh, JA; Sivaraman, A; Martinez, R; Cantoni, C; De Feo, L; Ghezzi, L; Minaya, MA; Renganathan, A; Cashikar, AG; Satoh, J; Beatty, W; Iyer, AK; Cella, M; Raskind, WH; Piccio, L; Karch, CM;
    2023;  
    Acta Neuropathologica;  
    Volume: 145;  
    Issue: 6;  
  65. Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia

    Gannon, OJ; Naik, JS; Riccio, D; Mansour, FM; Abi-Ghanem, C; Salinero, AE; Kelly, RD; Brooks, HL; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
  66. Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease

    Panyard, DJ; McKetney, J; Deming, YK; Morrow, AR; Ennis, GE; Jonaitis, EM; Van Hulle, CA; Yang, C; Sung, YJ; Ali, M; Kollmorgen, G; Suridjan, I; Bayfield, A; Bendlin, BB; Zetterberg, H; Blennow, K; Cruchaga, C; Carlsson, CM; Johnson, SC; Asthana, S; Coon, JJ; Engelman, CD;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  67. Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID

    Abi-Ghanem, C; Salinero, AE; Kordit, D; Mansour, FM; Kelly, RD; Venkataganesh, H; Kyaw, N; Gannon, OJ; Riccio, D; Fredman, G; Poitelon, Y; Belin, S; Kopec, AM; Robison, LS; Zuloaga, KL;
    2023;  
    Biology of Sex Differences;  
    Volume: 14;  
    Issue: 1;  
  68. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease

    Bourquard, T; Lee, K; Al-Ramahi, I; Pham, M; Shapiro, D; Lagisetty, Y; Soleimani, S; Mota, S; Wilhelm, K; Samieinasab, M; Kim, YW; Huh, E; Asmussen, J; Katsonis, P; Botas, J; Lichtarge, O;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  69. 2023;  
    Cell Stem Cell;  
    Volume: 30;  
    Issue: 5;  
  70. A global view of the genetic basis of Alzheimer disease

    Reitz, C; Pericak-Vance, MA; Foroud, T; Mayeux, R;
    2023;  
    Nature Reviews. Neurology;  
    Volume: 19;  
    Issue: 5;  
  71. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

    Qiao, M; Lee, AJ; Reyes-Dumeyer, D; Tosto, G; Faber, K; Goate, A; Renton, A; Chao, M; Boeve, B; Cruchaga, C; Pericak-Vance, M; Haines, JL; Rosenberg, R; Tsuang, D; Sweet, RA; Bennett, DA; Wilson, RS; Foroud, T; Mayeux, R; Vardarajan, BN;
    2023;  
    Annals of Clinical and Translational Neurology;  
    Volume: 10;  
    Issue: 5;  
  72. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease

    Huang, J; Stein, TD; Wang, Y; Ang, TFA; Tao, Q; Lunetta, KL; Massaro, J; Akhter-Khan, SC; Mez, J; Au, R; Farrer, LA; Zhang, X; Qiu, WQ; Alzheimer's Disease Neuroimaging Initiative;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 19;  
    Issue: 5;  
  73. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

    Ali, M; Archer, DB; Gorijala, P; Western, D; Timsina, J; Fernández, MV; Wang, T; Satizabal, CL; Yang, Q; Beiser, AS; Wang, R; Chen, G; Gordon, B; Benzinger, TLS; Xiong, C; Morris, JC; Bateman, RJ; Karch, CM; McDade, E; Goate, A; Seshadri, S; Mayeux, RP; Sperling, RA; Buckley, RF; Johnson, KA; Won, H; Jung, S; Kim, H; Seo, SW; Kim, HJ; Mormino, E; Laws, SM; Fan, K; Kamboh, MI; Vemuri, P; Ramanan, VK; Yang, H; Wenzel, A; Rajula, HSR; Mishra, A; Dufouil, C; Debette, S; Lopez, OL; DeKosky, ST; Tao, F; Nagle, MW; Knight Alzheimer Disease Research Center (Knight ADRC); Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); ADNI-DOD, A4 Study Team; Australian Imaging Biomarkers, Lifestyle (AIBL) Study; Hohman, TJ; Sung, YJ; Dumitrescu, L; Cruchaga, C;
    2023;  
    Acta Neuropathologica Communications;  
    Volume: 11;  
    Issue: 1;  
  74. Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer's and coronary disease pathways

    Wang, L; Western, D; Timsina, J; Repaci, C; Song, W; Norton, J; Kohlfeld, P; Budde, J; Climer, S; Butt, OH; Jacobson, D; Garvin, M; Templeton, AR; Campagna, S; O'Halloran, J; Presti, R; Goss, CW; Mudd, PA; Ances, BM; Zhang, B; Sung, YJ; Cruchaga, C;
    2023;  
    iScience;  
    Volume: 26;  
    Issue: 4;  
  75. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

    Brase, L; You, S; D'Oliveira Albanus, R; Del-Aguila, JL; Dai, Y; Novotny, BC; Soriano-Tarraga, C; Dykstra, T; Fernandez, MV; Budde, JP; Bergmann, K; Morris, JC; Bateman, RJ; Perrin, RJ; McDade, E; Xiong, C; Goate, AM; Farlow, M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland, GT; Kipnis, J; Karch, CM; Benitez, BA; Harari, O;
    2023;  
    Nature Communications;  
    Volume: 14;  
    Issue: 1;  
  76. Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity

    Honig, LS; Kang, MS; Lee, AJ; Reyes-Dumeyer, D; Piriz, A; Soriano, B; Franco, Y; Coronado, ZD; Recio, P; Mejía, DR; Medrano, M; Lantigua, RA; Teich, AF; Dage, JL; Mayeux, R;
    2023;  
    JAMA network open;  
    Volume: 6;  
    Issue: 4;  
  77. The complex genetic architecture of Alzheimer's disease: novel insights and future directions

    Andrews, SJ; Renton, AE; Fulton-Howard, B; Podlesny-Drabiniok, A; Marcora, E; Goate, AM;
    2023;  
    EBioMedicine;  
    Volume: 90;  
  78. 2023;  
    Neurobiology of Disease;  
    Volume: 179;  
  79. Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

    Pettigrew, C; Nazarovs, J; Soldan, A; Singh, V; Wang, J; Hohman, T; Dumitrescu, L; Libby, J; Kunkle, B; Gross, AL; Johnson, S; Lu, Q; Engelman, C; Masters, CL; Maruff, P; Laws, SM; Morris, JC; Hassenstab, J; Cruchaga, C; Resnick, SM; Kitner-Triolo, MH; An, Y; Albert, M;
    2023;  
    Alzheimer's Research & Therapy;  
    Volume: 15;  
    Issue: 1;  
  80. Evolutionarily conserved regulators of tau identify targets for new therapies

    Kim, J; de Haro, M; Al-Ramahi, I; Garaicoechea, LL; Jeong, H; Sonn, JY; Tadros, B; Liu, Z; Botas, J; Zoghbi, HY;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 6;  
  81. The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

    Maestre, G; Carrillo, M; Kalaria, R; Acosta, D; Adams, L; Adoukonou, T; Akinwande, K; Akinyemi, J; Akinyemi, R; Akpa, O; Alladi, S; Allegri, R; Arizaga, R; Arshad, F; Arulogun, O; Babalola, D; Baiyewu, O; Bak, T; Bellaj, T; Boshe, J; Brayne, C; Brodie-Mends, D; Brown, R; Cahn, J; Cyrille, N; Damasceno, A; de Silva, R; de Silva, R; Djibuti, M; Dreyer, AJ; Ellajosyula, R; Farombi, T; Fongang, B; Forner, S; Friedland, R; Garza, N; Gbessemehlan, A; Georgiou, EE; Gouider, R; Govia, I; Grinberg, L; Guerchet, M; Gugssa, S; Gumikiriza-Onoria, JL; Gustafson, D; Hogervorst, E; Hornberger, M; Ibanez, A; Ihara, M; Ismail, O; Issac, T; Jönsson, L; Kaputu, C; Karanja, W; Karungi, J; Tshala-Katumbay, D; Kunkle, B; Lee, JH; Leroi, I; Lewis, R; Livingston, G; Lopera, F; Lwere, K; Manes, F; Mbakile-Mahlanza, L; Mena, P; Miller, B; Millogo, A; Mohamed, A; Musyimi, C; Mutiso, V; Nakasujja, N; Ndetei, D; Nightingale, S; Njamnshi, AK; Novotni, G; Nyamayaro, P; Nyame, S; Ogeng'o, J; Ogunniyi, A; Okada De Oliveira, M; Okubadejo, N; Orrell, M; Orunmuyi, A; Owolabi, M; Paddick, S; A Pericak-Vance, M; Pirtosek, Z; Potocnik, F; Preston, B; Raman, R; Ranchod, K; Rizig, M; Rosselli, M; Deepa, R; Roy, U; Salokhiddinov, M; Sano, M; Sarfo, F; Satizabal, CL; Sepulveda-Falla, D; Seshadri, S; Sexton, C; Skoog, I; St George-Hyslop, P; Suemoto, C; Tanner, J; Thapa, P; Toure, K; Ucheagwu, V; Udeh-Momoh, C; Valcour, V; Vance, J; Varghese, M; Vera, J; Walker, R; Weidner, W; Sebastian, W; Whitehead Gay, P; Zetterberg, H; Zewde, Y; African Dementia Consortium;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  82. Identification of circRNAs linked to Alzheimer's disease and related dementias

    Puri, S; Hu, J; Sun, Z; Lin, M; Stein, TD; Farrer, LA; Wolozin, B; Zhang, X;
    2023;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  83. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

    Jiang, L; Chakraborty, P; Zhang, L; Wong, M; Hill, SE; Webber, CJ; Libera, J; Blair, LJ; Wolozin, B; Zweckstetter, M;
    2023;  
    Science Advances;  
    Volume: 9;  
    Issue: 5;  
  84. Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes

    Li, J; Amoh, BK; McCormick, E; Tarkunde, A; Zhu, KF; Perez, A; Mair, M; Moore, J; Shulman, JM; Al-Ramahi, I; Botas, J;
    2023;  
    Human Molecular Genetics;  
    Volume: 32;  
    Issue: 4;  
  85. Genetics and Pathogenesis of Parkinson's Syndrome

    Ye, H; Robak, LA; Yu, M; Cykowski, M; Shulman, JM;
    2023;  
    Annual Review of Pathology;  
    Volume: 18;  
  86. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

    Gratuze, M; Schlachetzki, JCM; D'Oliveira Albanus, R; Jain, N; Novotny, B; Brase, L; Rodriguez, L; Mansel, C; Kipnis, M; O'Brien, S; Pasillas, MP; Lee, C; Manis, M; Colonna, M; Harari, O; Glass, CK; Ulrich, JD; Holtzman, DM;
    2023;  
    Neuron;  
    Volume: 111;  
    Issue: 2;  
  87. Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

    Minaya, MA; Mahali, S; Iyer, AK; Eteleeb, AM; Martinez, R; Huang, G; Budde, J; Temple, S; Nana, AL; Seeley, WW; Spina, S; Grinberg, LT; Harari, O; Karch, CM;
    2023;  
    Frontiers in Molecular Biosciences;  
    Volume: 10;  
  88. The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms

    Felsky, D; Santa-Maria, I; Cosacak, MI; French, L; Schneider, JA; Bennett, DA; De Jager, PL; Kizil, C; Tosto, G;
    2023;  
    Neurobiology of Disease;  
    Volume: 176;  
  89. Understanding the molecular basis of resilience to Alzheimer's disease

    Montine, KS; Berson, E; Phongpreecha, T; Huang, Z; Aghaeepour, N; Zou, JY; MacCoss, MJ; Montine, TJ;
    2023;  
    Frontiers in Neuroscience;  
    Volume: 17;  
  90. Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?

    Mantyh, WG; Cochran, JN; Taylor, JW; Broce, IJ; Geier, EG; Bonham, LW; Anderson, AG; Sirkis, DW; Joie, RL; Iaccarino, L; Chaudhary, K; Edwards, L; Strom, A; Grant, H; Allen, IE; Miller, ZA; Gorno-Tempini, ML; Kramer, JH; Miller, BL; Desikan, RS; Rabinovici, GD; Yokoyama, JS;
    2023;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 15;  
    Issue: 4;  
  91. 2023;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 95;  
    Issue: 1;  
  92. Linking Air Pollution Exposure to Blood-Based Metabolic Features in a Community-Based Aging Cohort with and without Dementia

    Kalia, V; Kulick, ER; Vardarajan, B; Gu, Y; Manly, JJ; Elkind, MSV; Kaufman, JD; Jones, DP; Baccarelli, AA; Mayeux, R; Kioumourtzoglou, M; Miller, GW;
    2023;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 96;  
    Issue: 3;  
  93. Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

    De Guzman, RM; Rosinger, ZJ; Rybka, KA; Jacobskind, JS; Thrasher, CA; Caballero, AL; Sturm, KL; Sharif, MS; Abbas, MS; Parra, KE; Zuloaga, KL; Justice, NJ; Zuloaga, DG;
    2023;  
    Neuroendocrinology;  
    Volume: 113;  
    Issue: 8;  
  94. 2022

  95. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease

    Huang, J; Tao, Q; Ang, TFA; Farrell, J; Zhu, C; Wang, Y; Stein, TD; Lunetta, KL; Massaro, J; Mez, J; Au, R; Farrer, LA; Qiu, WQ; Zhang, X; Alzheimer’s Disease Neuroimaging Initiative;
    2022;  
    Translational Psychiatry;  
    Volume: 12;  
    Issue: 1;  
  96. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan

    Luo, J; Agboola, F; Grant, E; Morris, JC; Masters, CL; Albert, MS; Johnson, SC; McDade, EM; Fagan, AM; Benzinger, TLS; Hassenstab, J; Bateman, RJ; Perrin, RJ; Wang, G; Li, Y; Gordon, B; Cruchaga, C; Day, GS; Levin, J; Vöglein, J; Ikeuchi, T; Suzuki, K; Allegri, RF; Xiong, C; Dominantly Inherited Alzheimer Network (DIAN);
    2022;  
    Brain: A Journal of Neurology;  
    Volume: 145;  
    Issue: 12;  
  97. 2022;  
    Genome Medicine;  
    Volume: 14;  
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  98. Progranulin mutations in clinical and neuropathological Alzheimer's disease

    Vardarajan, BN; Reyes-Dumeyer, D; Piriz, AL; Lantigua, RA; Medrano, M; Rivera, D; Jiménez-Velázquez, IZ; Martin, E; Pericak-Vance, MA; Bush, W; Farrer, L; Haines, JL; Wang, L; Leung, YY; Schellenberg, G; Kukull, W; De Jager, P; Bennett, DA; Schneider, JA; Alzheimer's Disease Sequencing Project; Mayeux, R;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 12;  
  99. 2022;  
    Genome Medicine;  
    Volume: 14;  
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  100. Microglial efferocytosis: Diving into the Alzheimer's disease gene pool

    Romero-Molina, C; Garretti, F; Andrews, SJ; Marcora, E; Goate, AM;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 21;  
  101. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

    Drieu, A; Du, S; Storck, SE; Rustenhoven, J; Papadopoulos, Z; Dykstra, T; Zhong, F; Kim, K; Blackburn, S; Mamuladze, T; Harari, O; Karch, CM; Bateman, RJ; Perrin, R; Farlow, M; Chhatwal, J; Dominantly Inherited Alzheimer Network; Hu, S; Randolph, GJ; Smirnov, I; Kipnis, J;
    2022;  
    Nature;  
    Volume: 611;  
    Issue: 7936;  
  102. Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

    Katsumata, Y; Shade, LM; Hohman, TJ; Schneider, JA; Bennett, DA; Farfel, JM; Alzheimer’s Disease Genetics Consortium; Kukull, WA; Fardo, DW; Nelson, PT;
    2022;  
    Neurobiology of Disease;  
    Volume: 174;  
  103. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

    Jansen, IE; van der Lee, SJ; Gomez-Fonseca, D; de Rojas, I; Dalmasso, MC; Grenier-Boley, B; Zettergren, A; Mishra, A; Ali, M; Andrade, V; Bellenguez, C; Kleineidam, L; Küçükali, F; Sung, YJ; Tesí, N; Vromen, EM; Wightman, DP; Alcolea, D; Alegret, M; Alvarez, I; Amouyel, P; Athanasiu, L; Bahrami, S; Bailly, H; Belbin, O; Bergh, S; Bertram, L; Biessels, GJ; Blennow, K; Blesa, R; Boada, M; Boland, A; Buerger, K; Carracedo, Á; Cervera-Carles, L; Chene, G; Claassen, JAHR; Debette, S; Deleuze, J; de Deyn, PP; Diehl-Schmid, J; Djurovic, S; Dols-Icardo, O; Dufouil, C; Duron, E; Düzel, E; EADB consortium; Fladby, T; Fortea, J; Frölich, L; García-González, P; Garcia-Martinez, M; Giegling, I; Goldhardt, O; Gobom, J; Grimmer, T; Haapasalo, A; Hampel, H; Hanon, O; Hausner, L; Heilmann-Heimbach, S; Helisalmi, S; Heneka, MT; Hernández, I; Herukka, S; Holstege, H; Jarholm, J; Kern, S; Knapskog, A; Koivisto, AM; Kornhuber, J; Kuulasmaa, T; Lage, C; Laske, C; Leinonen, V; Lewczuk, P; Lleó, A; de Munain, AL; Lopez-Garcia, S; Maier, W; Marquié, M; Mol, MO; Montrreal, L; Moreno, F; Moreno-Grau, S; Nicolas, G; Nöthen, MM; Orellana, A; Pålhaugen, L; Papma, JM; Pasquier, F; Perneczky, R; Peters, O; Pijnenburg, YAL; Popp, J; Posthuma, D; Pozueta, A; Priller, J; Puerta, R; Quintela, I; Ramakers, I; Rodriguez-Rodriguez, E; Rujescu, D; Saltvedt, I; Sanchez-Juan, P; Scheltens, P; Scherbaum, N; Schmid, M; Schneider, A; Selbæk, G; Selnes, P; Shadrin, A; Skoog, I; Soininen, H; Tárraga, L; Teipel, S; GR@ACE study group; Tijms, B; Tsolaki, M; Van Broeckhoven, C; Van Dongen, J; van Swieten, JC; Vandenberghe, R; Vidal, J; Visser, PJ; Vogelgsang, J; Waern, M; Wagner, M; Wiltfang, J; Wittens, MMJ; Zetterberg, H; Zulaica, M; van Duijn, CM; Bjerke, M; Engelborghs, S; Jessen, F; Teunissen, CE; Pastor, P; Hiltunen, M; Ingelsson, M; Andreassen, OA; Clarimón, J; Sleegers, K; Ruiz, A; Ramirez, A; Cruchaga, C; Lambert, J; van der Flier, W;
    2022;  
    Acta Neuropathologica;  
    Volume: 144;  
    Issue: 5;  
  104. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

    Rickner, HD; Jiang, L; Hong, R; O'Neill, NK; Mojica, CA; Snyder, BJ; Zhang, L; Shaw, D; Medalla, M; Wolozin, B; Cheng, CS;
    2022;  
    Nature Communications;  
    Volume: 13;  
    Issue: 1;  
  105. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

    Novotny, BC; Fernandez, MV; Wang, C; Budde, JP; Bergmann, K; Eteleeb, AM; Bradley, J; Webster, C; Ebl, C; Norton, J; Gentsch, J; Dube, U; Wang, F; Morris, JC; Bateman, RJ; Perrin, RJ; McDade, E; Xiong, C; Chhatwal, J; Dominantly Inherited Alzheimer Network (DIAN) Study Group; Alzheimer's Disease Neuroimaging Initiative; and the Alzheimer's Disease Metabolomics Consortium (ADMC); Goate, A; Farlow, M; Schofield, P; Chui, H; Karch, CM; Cruchaga, C; Benitez, BA; Harari, O;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  106. Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets

    Nuytemans, K; Lipkin Vasquez, M; Wang, L; Van Booven, D; Griswold, AJ; Rajabli, F; Celis, K; Oron, O; Hofmann, N; Rolati, S; Garcia-Serje, C; Zhang, S; Jin, F; Argenziano, M; Grant, SFA; Chesi, A; Brown, CD; Young, JI; Dykxhoorn, DM; Pericak-Vance, MA; Vance, JM;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
  107. The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery

    Reyes-Dumeyer, D; Faber, K; Vardarajan, B; Goate, A; Renton, A; Chao, M; Boeve, B; Cruchaga, C; Pericak-Vance, M; Haines, JL; Rosenberg, R; Tsuang, D; Sweet, RA; Bennett, DA; Wilson, RS; Foroud, T; Mayeux, R;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
  108. Whole genome sequencing-based copy number variations reveal novel pathways and targets in Alzheimer's disease

    Ming, C; Wang, M; Wang, Q; Neff, R; Wang, E; Shen, Q; Reddy, JS; Wang, X; Allen, M; Ertekin-Taner, N; De Jager, PL; Bennett, DA; Haroutunian, V; Schadt, E; Zhang, B;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
  109. Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance

    Gao, Y; Felsky, D; Reyes-Dumeyer, D; Sariya, S; Rentería, MA; Ma, Y; Klein, H; Cosentino, S; De Jager, PL; Bennett, DA; Brickman, AM; Schellenberg, GD; Mayeux, R; Barral, S; CHAP, UKBB, ADNI, ROSMAP, LLFS, NIA-LOAD and ADGC consortia;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 10;  
  110. Mosaic loss of Chromosome Y in aged human microglia

    Vermeulen, MC; Pearse, R; Young-Pearse, T; Mostafavi, S;
    2022;  
    Genome Research;  
    Volume: 32;  
    Issue: 10;  
  111. 2022;  
    STAR protocols;  
    Volume: 3;  
    Issue: 3;  
  112. Identification of risk genes for Alzheimer's disease by gene embedding

    Lagisetty, Y; Bourquard, T; Al-Ramahi, I; Mangleburg, CG; Mota, S; Soleimani, S; Shulman, JM; Botas, J; Lee, K; Lichtarge, O;
    2022;  
    Cell Genomics;  
    Volume: 2;  
    Issue: 9;  
  113. 2022;  
    Trends in genetics: TIG;  
    Volume: 38;  
    Issue: 9;  
  114. 2022;  
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences;  
    Volume: 77;  
    Issue: 9;  
  115. Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults

    Pa, J; Aslanyan, V; Casaletto, KB; Rentería, MA; Harrati, A; Tom, SE; Armstrong, N; Rajan, K; Avila-Rieger, J; Gu, Y; Schupf, N; Manly, JJ; Brickman, A; Zahodne, L;
    2022;  
    Neurology;  
    Volume: 99;  
    Issue: 8;  
  116. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

    Saroja, SR; Gorbachev, K; Julia, T; Goate, AM; Pereira, AC;
    2022;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 119;  
    Issue: 34;  
  117. Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

    Ibanez, L; Heitsch, L; Carrera, C; Farias, FHG; Del Aguila, JL; Dhar, R; Budde, J; Bergmann, K; Bradley, J; Harari, O; Phuah, CL; Lemmens, R; Viana Oliveira Souza, AA; Moniche, F; Cabezas-Juan, A; Arenillas, JF; Krupinksi, J; Cullell, N; Torres-Aguila, N; Muiño, E; Cárcel-Márquez, J; Marti-Fabregas, J; Delgado-Mederos, R; Marin-Bueno, R; Hornick, A; Vives-Bauza, C; Navarro, RD; Tur, S; Jimenez, C; Obach, V; Segura, T; Serrano-Heras, G; Chung, JW; Roquer, J; Soriano-Tarraga, C; Giralt-Steinhauer, E; Mola-Caminal, M; Pera, J; Lapicka-Bodzioch, K; Derbisz, J; Davalos, A; Lopez-Cancio, E; Muñoz, L; Tatlisumak, T; Molina, C; Ribo, M; Bustamante, A; Sobrino, T; Castillo-Sanchez, J; Campos, F; Rodriguez-Castro, E; Arias-Rivas, S; Rodríguez-Yáñez, M; Herbosa, C; Ford, AL; Gutierrez-Romero, A; Uribe-Pacheco, R; Arauz, A; Lopes-Cendes, I; Lowenkopf, T; Barboza, MA; Amini, H; Stamova, B; Ander, BP; Sharp, FR; Kim, GM; Bang, OY; Jimenez-Conde, J; Slowik, A; Stribian, D; Tsai, EA; Burkly, LC; Montaner, J; Fernandez-Cadenas, I; Lee, JM; Cruchaga, C;
    2022;  
    Brain: A Journal of Neurology;  
    Volume: 145;  
    Issue: 7;  
  118. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry

    Rajabli, F; Beecham, GW; Hendrie, HC; Baiyewu, O; Ogunniyi, A; Gao, S; Kushch, NA; Lipkin-Vasquez, M; Hamilton-Nelson, KL; Young, JI; Dykxhoorn, DM; Nuytemans, K; Kunkle, BW; Wang, L; Jin, F; Liu, X; Feliciano-Astacio, BE; Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium; Schellenberg, GD; Dalgard, CL; Griswold, AJ; Byrd, GS; Reitz, C; Cuccaro, ML; Haines, JL; Pericak-Vance, MA; Vance, JM;
    2022;  
    PLoS genetics;  
    Volume: 18;  
    Issue: 7;  
  119. DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution

    Zhang, S; Plummer, D; Lu, L; Cui, J; Xu, W; Wang, M; Liu, X; Prabhakar, N; Shrinet, J; Srinivasan, D; Fraser, P; Li, Y; Li, J; Jin, F;
    2022;  
    Nature Genetics;  
    Volume: 54;  
    Issue: 7;  
  120. Fine-mapping from summary data with the "Sum of Single Effects" model

    Zou, Y; Carbonetto, P; Wang, G; Stephens, M;
    2022;  
    PLoS genetics;  
    Volume: 18;  
    Issue: 7;  
  121. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

    Lee, AJ; Raghavan, NS; Bhattarai, P; Siddiqui, T; Sariya, S; Reyes-Dumeyer, D; Flowers, XE; Cardoso, SAL; De Jager, PL; Bennett, DA; Schneider, JA; Menon, V; Wang, Y; Lantigua, RA; Medrano, M; Rivera, D; Jiménez-Velázquez, IZ; Kukull, WA; Brickman, AM; Manly, JJ; Tosto, G; Kizil, C; Vardarajan, BN; Mayeux, R;
    2022;  
    Acta Neuropathologica;  
    Volume: 144;  
    Issue: 1;  
  122. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

    Tcw, J; Qian, L; Pipalia, NH; Chao, MJ; Liang, SA; Shi, Y; Jain, BR; Bertelsen, SE; Kapoor, M; Marcora, E; Sikora, E; Andrews, EJ; Martini, AC; Karch, CM; Head, E; Holtzman, DM; Zhang, B; Wang, M; Maxfield, FR; Poon, WW; Goate, AM;
    2022;  
    Cell;  
    Volume: 185;  
    Issue: 13;  
  123. Integration of rare expression outlier-associated variants improves polygenic risk prediction

    Smail, C; Ferraro, NM; Hui, Q; Durrant, MG; Aguirre, M; Tanigawa, Y; Keever-Keigher, MR; Rao, AS; Justesen, JM; Li, X; Gloudemans, MJ; Assimes, TL; Kooperberg, C; Reiner, AP; Huang, J; O'Donnell, CJ; Sun, YV; Million Veteran Program; Rivas, MA; Montgomery, SB;
    2022;  
    American Journal of Human Genetics;  
    Volume: 109;  
    Issue: 6;  
  124. Chromatin accessibility profiling by ATAC-seq

    Grandi, FC; Modi, H; Kampman, L; Corces, MR;
    2022;  
    Nature Protocols;  
    Volume: 17;  
    Issue: 6;  
  125. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

    Horgusluoglu, E; Neff, R; Song, W; Wang, M; Wang, Q; Arnold, M; Krumsiek, J; Galindo-Prieto, B; Ming, C; Nho, K; Kastenmüller, G; Han, X; Baillie, R; Zeng, Q; Andrews, S; Cheng, H; Hao, K; Goate, A; Bennett, DA; Saykin, AJ; Kaddurah-Daouk, R; Zhang, B; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Metabolomics Consortium;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 6;  
  126. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1

    Kizil, C; Sariya, S; Kim, YA; Rajabli, F; Martin, E; Reyes-Dumeyer, D; Vardarajan, B; Maldonado, A; Haines, JL; Mayeux, R; Jiménez-Velázquez, IZ; Santa-Maria, I; Tosto, G;
    2022;  
    Molecular Psychiatry;  
    Volume: 27;  
    Issue: 6;  
  127. High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

    Gannon, OJ; Robison, LS; Salinero, AE; Abi-Ghanem, C; Mansour, FM; Kelly, RD; Tyagi, A; Brawley, RR; Ogg, JD; Zuloaga, KL;
    2022;  
    Journal of Neuroinflammation;  
    Volume: 19;  
    Issue: 1;  
  128. Molecular Quantitative Trait Locus Mapping in Human Complex Diseases

    Olayinka, OA; O'Neill, NK; Farrer, LA; Wang, G; Zhang, X;
    2022;  
    Current Protocols;  
    Volume: 2;  
    Issue: 5;  
  129. 2022;  
    Journal of Clinical Periodontology;  
    Volume: 49;  
    Issue: 5;  
  130. Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice

    Lyons, CE; Zhou, X; Razzoli, M; Chen, M; Xia, W; Ashe, K; Zhang, B; Bartolomucci, A;
    2022;  
    The European Journal of Neuroscience;  
    Volume: 55;  
    Issue: 9-10;  
  131. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

    Martens, YA; Zhao, N; Liu, C; Kanekiyo, T; Yang, AJ; Goate, AM; Holtzman, DM; Bu, G;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 8;  
  132. 2022;  
    Med (New York, N.Y.);  
    Volume: 3;  
    Issue: 4;  
  133. Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

    Meijer, M; Agirre, E; Kabbe, M; van Tuijn, CA; Heskol, A; Zheng, C; Mendanha Falcão, A; Bartosovic, M; Kirby, L; Calini, D; Johnson, MR; Corces, MR; Montine, TJ; Chen, X; Chang, HY; Malhotra, D; Castelo-Branco, G;
    2022;  
    Neuron;  
    Volume: 110;  
    Issue: 7;  
  134. Replication study of AD-associated rare variants

    Neupane, A; Lenny, B; Budde, JP; Wang, F; Norton, J; Morris, JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga, C; Fernández, MV;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 4;  
  135. Soluble TREM2: Innocent bystander or active player in neurological diseases?

    Filipello, F; Goldsbury, C; You, SF; Locca, A; Karch, CM; Piccio, L;
    2022;  
    Neurobiology of Disease;  
    Volume: 165;  
  136. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns

    Jin, B; Capra, JA; Benchek, P; Wheeler, N; Naj, AC; Hamilton-Nelson, KL; Farrell, JJ; Leung, YY; Kunkle, B; Vadarajan, B; Schellenberg, GD; Mayeux, R; Wang, L; Farrer, LA; Pericak-Vance, MA; Martin, ER; Haines, JL; Crawford, DC; Bush, WS;
    2022;  
    Genome Research;  
    Volume: 32;  
    Issue: 4;  
  137. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

    Morenas-Rodríguez, E; Li, Y; Nuscher, B; Franzmeier, N; Xiong, C; Suárez-Calvet, M; Fagan, AM; Schultz, S; Gordon, BA; Benzinger, TLS; Hassenstab, J; McDade, E; Feederle, R; Karch, CM; Schlepckow, K; Morris, JC; Kleinberger, G; Nellgard, B; Vöglein, J; Blennow, K; Zetterberg, H; Ewers, M; Jucker, M; Levin, J; Bateman, RJ; Haass, C; Dominantly Inherited Alzheimer Network;
    2022;  
    The Lancet. Neurology;  
    Volume: 21;  
    Issue: 4;  
  138. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

    Chen, H; Eteleeb, A; Wang, C; Fernandez, MV; Budde, JP; Bergmann, K; Norton, J; Wang, F; Ebl, C; Morris, JC; Perrin, RJ; Bateman, RJ; McDade, E; Xiong, C; Goate, A; Farlow, M; Chhatwal, J; Schofield, PR; Chui, H; Harari, O; Cruchaga, C; Ibanez, L; Dominantly Inherited Alzheimer Network;
    2022;  
    Acta Neuropathologica Communications;  
    Volume: 10;  
    Issue: 1;  
  139. APOE4 confers transcriptomic and functional alterations to primary mouse microglia

    Machlovi, SI; Neuner, SM; Hemmer, BM; Khan, R; Liu, Y; Huang, M; Zhu, JD; Castellano, JM; Cai, D; Marcora, E; Goate, AM;
    2022;  
    Neurobiology of Disease;  
    Volume: 164;  
  140. Social network characteristics moderate associations between cortical thickness and cognitive functioning in older adults

    Sharifian, N; Zaheed, AB; Morris, EP; Sol, K; Manly, JJ; Schupf, N; Mayeux, R; Brickman, AM; Zahodne, LB;
    2022;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 18;  
    Issue: 2;  
  141. 2022;  
    Current Opinion in Neurobiology;  
    Volume: 72;  
  142. Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

    Bigley, TM; Xiong, M; Ali, M; Chen, Y; Wang, C; Serrano, JR; Eteleeb, A; Harari, O; Yang, L; Patel, SJ; Cruchaga, C; Yokoyama, WM; Holtzman, DM;
    2022;  
    Molecular Neurodegeneration;  
    Volume: 17;  
    Issue: 1;  
  143. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

    Xu, P; Wang, M; Song, W; Wang, Q; Yuan, G; Sudmant, PH; Zare, H; Tu, Z; Orr, ME; Zhang, B;
    2022;  
    Molecular Neurodegeneration;  
    Volume: 17;  
    Issue: 1;  
  144. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population

    Angevaare, MJ; Vonk, JMJ; Bertola, L; Zahodne, L; Watson, CW; Boehme, A; Schupf, N; Mayeux, R; Geerlings, MI; Manly, JJ;
    2022;  
    Neurology;  
    Volume: 98;  
    Issue: 1;  
  145. Genome-wide association study and functional validation implicates JADE1 in tauopathy

    Farrell, K; Kim, S; Han, N; Iida, MA; Gonzalez, EM; Otero-Garcia, M; Walker, JM; Richardson, TE; Renton, AE; Andrews, SJ; Fulton-Howard, B; Humphrey, J; Vialle, RA; Bowles, KR; de Paiva Lopes, K; Whitney, K; Dangoor, DK; Walsh, H; Marcora, E; Hefti, MM; Casella, A; Sissoko, CT; Kapoor, M; Novikova, G; Udine, E; Wong, G; Tang, W; Bhangale, T; Hunkapiller, J; Ayalon, G; Graham, RR; Cherry, JD; Cortes, EP; Borukov, VY; McKee, AC; Stein, TD; Vonsattel, J; Teich, AF; Gearing, M; Glass, J; Troncoso, JC; Frosch, MP; Hyman, BT; Dickson, DW; Murray, ME; Attems, J; Flanagan, ME; Mao, Q; Mesulam, M; Weintraub, S; Woltjer, RL; Pham, T; Kofler, J; Schneider, JA; Yu, L; Purohit, DP; Haroutunian, V; Hof, PR; Gandy, S; Sano, M; Beach, TG; Poon, W; Kawas, CH; Corrada, MM; Rissman, RA; Metcalf, J; Shuldberg, S; Salehi, B; Nelson, PT; Trojanowski, JQ; Lee, EB; Wolk, DA; McMillan, CT; Keene, CD; Latimer, CS; Montine, TJ; Kovacs, GG; Lutz, MI; Fischer, P; Perrin, RJ; Cairns, NJ; Franklin, EE; Cohen, HT; Raj, T; Cobos, I; Frost, B; Goate, A; White Iii, CL; Crary, JF;
    2022;  
    Acta Neuropathologica;  
    Volume: 143;  
    Issue: 1;  
  146. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

    Ali, M; Sung, YJ; Wang, F; Fernández, MV; Morris, JC; Fagan, AM; Blennow, K; Zetterberg, H; Heslegrave, A; Johansson, PM; Svensson, J; Nellgård, B; Lleó, A; Alcolea, D; Clarimon, J; Rami, L; Molinuevo, JL; Suárez-Calvet, M; Morenas-Rodríguez, E; Kleinberger, G; Haass, C; Ewers, M; Levin, J; Farlow, MR; Perrin, RJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN); Cruchaga, C;
    2022;  
    PloS One;  
    Volume: 17;  
    Issue: 5;  
  147. Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach

    Timsina, J; Gomez-Fonseca, D; Wang, L; Do, A; Western, D; Alvarez, I; Aguilar, M; Pastor, P; Henson, RL; Herries, E; Xiong, C; Schindler, SE; Fagan, AM; Bateman, RJ; Farlow, M; Morris, JC; Perrin, RJ; Moulder, K; Hassenstab, J; Vöglein, J; Chhatwal, J; Mori, H; Alzheimer’s Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network Consortia; Sung, YJ; Cruchaga, C;
    2022;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 89;  
    Issue: 1;  
  148. 2021

  149. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

    Moulton, MJ; Barish, S; Ralhan, I; Chang, J; Goodman, LD; Harland, JG; Marcogliese, PC; Johansson, JO; Ioannou, MS; Bellen, HJ;
    2021;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 118;  
    Issue: 52;  
  150. 2021;  
    Autophagy;  
    Volume: 17;  
    Issue: 12;  
  151. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

    Lagomarsino, VN; Pearse, RV; Liu, L; Hsieh, Y; Fernandez, MA; Vinton, EA; Paull, D; Felsky, D; Tasaki, S; Gaiteri, C; Vardarajan, B; Lee, H; Muratore, CR; Benoit, CR; Chou, V; Fancher, SB; He, A; Merchant, JP; Duong, DM; Martinez, H; Zhou, M; Bah, F; Vicent, MA; Stricker, JMS; Xu, J; Dammer, EB; Levey, AI; Chibnik, LB; Menon, V; Seyfried, NT; De Jager, PL; Noggle, S; Selkoe, DJ; Bennett, DA; Young-Pearse, TL;
    2021;  
    Neuron;  
    Volume: 109;  
    Issue: 21;  
  152. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

    Jiang, L; Lin, W; Zhang, C; Ash, PEA; Verma, M; Kwan, J; van Vliet, E; Yang, Z; Cruz, AL; Boudeau, S; Maziuk, BF; Lei, S; Song, J; Alvarez, VE; Hovde, S; Abisambra, JF; Kuo, M; Kanaan, N; Murray, ME; Crary, JF; Zhao, J; Cheng, J; Petrucelli, L; Li, H; Emili, A; Wolozin, B;
    2021;  
    Molecular Cell;  
    Volume: 81;  
    Issue: 20;  
  153. KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease

    Siddiqui, T; Bhattarai, P; Popova, S; Cosacak, MI; Sariya, S; Zhang, Y; Mayeux, R; Tosto, G; Kizil, C;
    2021;  
    Cells;  
    Volume: 10;  
    Issue: 10;  
  154. Large scale enzyme based xenobiotic identification for exposomics

    Liu, KH; Lee, CM; Singer, G; Bais, P; Castellanos, F; Woodworth, MH; Ziegler, TR; Kraft, CS; Miller, GW; Li, S; Go, Y; Morgan, ET; Jones, DP;
    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
  155. Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease

    Li, F; Eteleeb, A; Buchser, W; Wang, G; Xiong, C; Payne, PR; McDade, E; Karch, CM; Harari, O; Cruchaga, C;
    2021;  
    bioRxiv: The Preprint Server for Biology;  
  156. Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics

    Sariya, S; Felsky, D; Reyes-Dumeyer, D; Lali, R; Lantigua, RA; Vardarajan, B; Jiménez-Velázquez, IZ; Haines, JL; Shellenberg, GD; Pericak-Vance, MA; Paré, G; Mayeux, R; Tosto, G;
    2021;  
    Annals of Neurology;  
    Volume: 90;  
    Issue: 3;  
  157. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

    Yang, C; Farias, FHG; Ibanez, L; Suhy, A; Sadler, B; Fernandez, MV; Wang, F; Bradley, JL; Eiffert, B; Bahena, JA; Budde, JP; Li, Z; Dube, U; Sung, YJ; Mihindukulasuriya, KA; Morris, JC; Fagan, AM; Perrin, RJ; Benitez, BA; Rhinn, H; Harari, O; Cruchaga, C;
    2021;  
    Nature Neuroscience;  
    Volume: 24;  
    Issue: 9;  
  158. Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression

    Saito, ER; Miller, JB; Harari, O; Cruchaga, C; Mihindukulasuriya, KA; Kauwe, JSK; Bikman, BT;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 9;  
  159. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis

    Cao, J; Huang, M; Guo, L; Zhu, L; Hou, J; Zhang, L; Pero, A; Ng, S; El Gaamouch, F; Elder, G; Sano, M; Goate, A; Tcw, J; Haroutunian, V; Zhang, B; Cai, D;
    2021;  
    Molecular Psychiatry;  
    Volume: 26;  
    Issue: 9;  
  160. 2021;  
    Archives of Clinical Neuropsychology: The Official Journal of the National Academy of Neuropsychologists;  
    Volume: 36;  
    Issue: 6;  
  161. 2021;  
    Genes;  
    Volume: 12;  
    Issue: 8;  
  162. Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study

    Brickman, AM; Manly, JJ; Honig, LS; Sanchez, D; Reyes-Dumeyer, D; Lantigua, RA; Lao, PJ; Stern, Y; Vonsattel, JP; Teich, AF; Airey, DC; Proctor, NK; Dage, JL; Mayeux, R;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 8;  
  163. Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery

    Chung, MK; Rappaport, SM; Wheelock, CE; Nguyen, VK; van der Meer, TP; Miller, GW; Vermeulen, R; Patel, CJ;
    2021;  
    Environmental Health Perspectives;  
    Volume: 129;  
    Issue: 8;  
  164. 2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
  165. Neuronal VCP loss of function recapitulates FTLD-TDP pathology

    Wani, A; Zhu, J; Ulrich, JD; Eteleeb, A; Sauerbeck, AD; Reitz, SJ; Arhzaouy, K; Ikenaga, C; Yuede, CM; Pittman, SK; Wang, F; Li, S; Benitez, BA; Cruchaga, C; Kummer, TT; Harari, O; Chou, T; Schröder, R; Clemen, CS; Weihl, CC;
    2021;  
    Cell Reports;  
    Volume: 36;  
    Issue: 3;  
  166. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds

    Griswold, AJ; Celis, K; Bussies, PL; Rajabli, F; Whitehead, PL; Hamilton-Nelson, KL; Beecham, GW; Dykxhoorn, DM; Nuytemans, K; Wang, L; Gardner, OK; Dorfsman, DA; Bigio, EH; Mesulam, MM; Weintraub, S; Geula, C; Gearing, M; McGrath-Martinez, E; Dalgard, CL; Scott, WK; Haines, JL; Pericak-Vance, MA; Young, JI; Vance, JM;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 7;  
  167. Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease

    Zhang, X; Farrell, JJ; Tong, T; Hu, J; Zhu, C; Alzheimer's Disease Sequencing Project; Wang, L; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GD; Lunetta, KL; Farrer, LA;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  168. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; Franco-Macías, E; Macías, J; Blesa, R; Cervera-Carles, L; Menéndez-González, M; Frank-García, A; Royo, JL; Moreno, F; Huerto Vilas, R; Baquero, M; Diez-Fairen, M; Lage, C; García-Madrona, S; García-González, P; Alarcón-Martín, E; Valero, S; Sotolongo-Grau, O; Ullgren, A; Naj, AC; Lemstra, AW; Benaque, A; Pérez-Cordón, A; Benussi, A; Rábano, A; Padovani, A; Squassina, A; de Mendonça, A; Arias Pastor, A; Kok, AAL; Meggy, A; Pastor, AB; Espinosa, A; Corma-Gómez, A; Martín Montes, A; Sanabria, Á; DeStefano, AL; Schneider, A; Haapasalo, A; Kinhult Ståhlbom, A; Tybjærg-Hansen, A; Hartmann, AM; Spottke, A; Corbatón-Anchuelo, A; Rongve, A; Borroni, B; Arosio, B; Nacmias, B; Nordestgaard, BG; Kunkle, BW; Charbonnier, C; Abdelnour, C; Masullo, C; Martínez Rodríguez, C; Muñoz-Fernandez, C; Dufouil, C; Graff, C; Ferreira, CB; Chillotti, C; Reynolds, CA; Fenoglio, C; Van Broeckhoven, C; Clark, C; Pisanu, C; Satizabal, CL; Holmes, C; Buiza-Rueda, D; Aarsland, D; Rujescu, D; Alcolea, D; Galimberti, D; Wallon, D; Seripa, D; Grünblatt, E; Dardiotis, E; Düzel, E; Scarpini, E; Conti, E; Rubino, E; Gelpi, E; Rodriguez-Rodriguez, E; Duron, E; Boerwinkle, E; Ferri, E; Tagliavini, F; Küçükali, F; Pasquier, F; Sanchez-Garcia, F; Mangialasche, F; Jessen, F; Nicolas, G; Selbæk, G; Ortega, G; Chêne, G; Hadjigeorgiou, G; Rossi, G; Spalletta, G; Giaccone, G; Grande, G; Binetti, G; Papenberg, G; Hampel, H; Bailly, H; Zetterberg, H; Soininen, H; Karlsson, IK; Alvarez, I; Appollonio, I; Giegling, I; Skoog, I; Saltvedt, I; Rainero, I; Rosas Allende, I; Hort, J; Diehl-Schmid, J; Van Dongen, J; Vidal, J; Lehtisalo, J; Wiltfang, J; Thomassen, JQ; Kornhuber, J; Haines, JL; Vogelgsang, J; Pineda, JA; Fortea, J; Popp, J; Deckert, J; Buerger, K; Morgan, K; Fließbach, K; Sleegers, K; Molina-Porcel, L; Kilander, L; Weinhold, L; Farrer, LA; Wang, L; Kleineidam, L; Farotti, L; Parnetti, L; Tremolizzo, L; Hausner, L; Benussi, L; Froelich, L; Ikram, MA; Deniz-Naranjo, MC; Tsolaki, M; Rosende-Roca, M; Löwenmark, M; Hulsman, M; Spallazzi, M; Pericak-Vance, MA; Esiri, M; Bernal Sánchez-Arjona, M; Dalmasso, MC; Martínez-Larrad, MT; Arcaro, M; Nöthen, MM; Fernández-Fuertes, M; Dichgans, M; Ingelsson, M; Herrmann, MJ; Scherer, M; Vyhnalek, M; Kosmidis, MH; Yannakoulia, M; Schmid, M; Ewers, M; Heneka, MT; Wagner, M; Scamosci, M; Kivipelto, M; Hiltunen, M; Zulaica, M; Alegret, M; Fornage, M; Roberto, N; van Schoor, NM; Seidu, NM; Banaj, N; Armstrong, NJ; Scarmeas, N; Scherbaum, N; Goldhardt, O; Hanon, O; Peters, O; Skrobot, OA; Quenez, O; Lerch, O; Bossù, P; Caffarra, P; Dionigi Rossi, P; Sakka, P; Mecocci, P; Hoffmann, P; Holmans, PA; Fischer, P; Riederer, P; Yang, Q; Marshall, R; Kalaria, RN; Mayeux, R; Vandenberghe, R; Cecchetti, R; Ghidoni, R; Frikke-Schmidt, R; Sorbi, S; Hägg, S; Engelborghs, S; Helisalmi, S; Botne Sando, S; Kern, S; Archetti, S; Boschi, S; Fostinelli, S; Gil, S; Mendoza, S; Mead, S; Ciccone, S; Djurovic, S; Heilmann-Heimbach, S; Riedel-Heller, S; Kuulasmaa, T; Del Ser, T; Lebouvier, T; Polak, T; Ngandu, T; Grimmer, T; Bessi, V; Escott-Price, V; Giedraitis, V; Deramecourt, V; Maier, W; Jian, X; Pijnenburg, YAL; EADB contributors; GR@ACE study group; DEGESCO consortium; IGAP (ADGC, CHARGE, EADI, GERAD); PGC-ALZ consortia; Kehoe, PG; Garcia-Ribas, G; Sánchez-Juan, P; Pastor, P; Pérez-Tur, J; Piñol-Ripoll, G; Lopez de Munain, A; García-Alberca, JM; Bullido, MJ; Álvarez, V; Lleó, A; Real, LM; Mir, P; Medina, M; Scheltens, P; Holstege, H; Marquié, M; Sáez, ME; Carracedo, Á; Amouyel, P; Schellenberg, GD; Williams, J; Seshadri, S; van Duijn, CM; Mather, KA; Sánchez-Valle, R; Serrano-Ríos, M; Orellana, A; Tárraga, L; Blennow, K; Huisman, M; Andreassen, OA; Posthuma, D; Clarimón, J; Boada, M; van der Flier, WM; Ramirez, A; Lambert, J; van der Lee, SJ; Ruiz, A;
    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
  169. Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease

    Qin, W; Zhou, A; Zuo, X; Jia, L; Li, F; Wang, Q; Li, Y; Wei, Y; Jin, H; Cruchaga, C; Benitez, BA; Jia, J;
    2021;  
    Human Molecular Genetics;  
    Volume: 30;  
    Issue: 9;  
  170. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

    Guo, J; Brickman, AM; Manly, JJ; Reitz, C; Schupf, N; Mayeux, RP; Gu, Y;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
  171. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

    Da Mesquita, S; Papadopoulos, Z; Dykstra, T; Brase, L; Farias, FG; Wall, M; Jiang, H; Kodira, CD; de Lima, KA; Herz, J; Louveau, A; Goldman, DH; Salvador, AF; Onengut-Gumuscu, S; Farber, E; Dabhi, N; Kennedy, T; Milam, MG; Baker, W; Smirnov, I; Rich, SS; Dominantly Inherited Alzheimer Network; Benitez, BA; Karch, CM; Perrin, RJ; Farlow, M; Chhatwal, JP; Holtzman, DM; Cruchaga, C; Harari, O; Kipnis, J;
    2021;  
    Nature;  
    Volume: 593;  
    Issue: 7858;  
  172. 2021;  
    Medicinal Research Reviews;  
    Volume: 41;  
    Issue: 3;  
  173. Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue

    Patel, D; Zhang, X; Farrell, JJ; Chung, J; Stein, TD; Lunetta, KL; Farrer, LA;
    2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
  174. African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

    Schindler, SE; Cruchaga, C; Joseph, A; McCue, L; Farias, FHG; Wilkins, CH; Deming, Y; Henson, RL; Mikesell, RJ; Piccio, L; Llibre-Guerra, JJ; Moulder, KL; Fagan, AM; Ances, BM; Benzinger, TLS; Xiong, C; Holtzman, DM; Morris, JC;
    2021;  
    Neurology. Genetics;  
    Volume: 7;  
    Issue: 2;  
  175. Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

    Kirola, L; Budde, JP; Wang, F; Norton, J; Morris, JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga, C; Fernández, MV;
    2021;  
    Acta Neuropathologica;  
    Volume: 141;  
    Issue: 4;  
  176. 2021;  
    Genes;  
    Volume: 12;  
    Issue: 3;  
  177. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

    Novikova, G; Kapoor, M; Tcw, J; Abud, EM; Efthymiou, AG; Chen, SX; Cheng, H; Fullard, JF; Bendl, J; Liu, Y; Roussos, P; Björkegren, JL; Liu, Y; Poon, WW; Hao, K; Marcora, E; Goate, AM;
    2021;  
    Nature Communications;  
    Volume: 12;  
    Issue: 1;  
  178. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

    Ash, PEA; Lei, S; Shattuck, J; Boudeau, S; Carlomagno, Y; Medalla, M; Mashimo, BL; Socorro, G; Al-Mohanna, LFA; Jiang, L; Öztürk, MM; Knobel, M; Ivanov, P; Petrucelli, L; Wegmann, S; Kanaan, NM; Wolozin, B;
    2021;  
    Proceedings of the National Academy of Sciences of the United States of America;  
    Volume: 118;  
    Issue: 9;  
  179. Socioeconomic and psychosocial mechanisms underlying racial/ethnic disparities in cognition among older adults

    Zahodne, LB; Sharifian, N; Kraal, AZ; Zaheed, AB; Sol, K; Morris, EP; Schupf, N; Manly, JJ; Brickman, AM;
    2021;  
    Neuropsychology;  
    Volume: 35;  
    Issue: 3;  
  180. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers

    Fulton-Howard, B; Goate, AM; Adelson, RP; Koppel, J; Gordon, ML; Alzheimer's Disease Genetics Consortium; Barzilai, N; Atzmon, G; Davies, P; Freudenberg-Hua, Y;
    2021;  
    Neurobiology of Aging;  
    Volume: 99;  
  181. Long runs of homozygosity are associated with Alzheimer's disease

    Moreno-Grau, S; Fernández, MV; de Rojas, I; Garcia-González, P; Hernández, I; Farias, F; Budde, JP; Quintela, I; Madrid, L; González-Pérez, A; Montrreal, L; Alarcón-Martín, E; Alegret, M; Maroñas, O; Pineda, JA; Macías, J; GR@ACE study group; DEGESCO consortium; Marquié, M; Valero, S; Benaque, A; Clarimón, J; Bullido, MJ; García-Ribas, G; Pástor, P; Sánchez-Juan, P; Álvarez, V; Piñol-Ripoll, G; García-Alberca, JM; Royo, JL; Franco-Macías, E; Mir, P; Calero, M; Medina, M; Rábano, A; Ávila, J; Antúnez, C; Real, LM; Orellana, A; Carracedo, Á; Sáez, ME; Tárraga, L; Boada, M; Cruchaga, C; Ruiz, A; Alzheimer’s Disease Neuroimaging Initiative;
    2021;  
    Translational Psychiatry;  
    Volume: 11;  
    Issue: 1;  
  182. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

    Wang, M; Li, A; Sekiya, M; Beckmann, ND; Quan, X; Schrode, N; Fernando, MB; Yu, A; Zhu, L; Cao, J; Lyu, L; Horgusluoglu, E; Wang, Q; Guo, L; Wang, Y; Neff, R; Song, W; Wang, E; Shen, Q; Zhou, X; Ming, C; Ho, S; Vatansever, S; Kaniskan, HÜ; Jin, J; Zhou, M; Ando, K; Ho, L; Slesinger, PA; Yue, Z; Zhu, J; Katsel, P; Gandy, S; Ehrlich, ME; Fossati, V; Noggle, S; Cai, D; Haroutunian, V; Iijima, KM; Schadt, E; Brennand, KJ; Zhang, B;
    2021;  
    Neuron;  
    Volume: 109;  
    Issue: 2;  
  183. The variant call format provides efficient and robust storage of GWAS summary statistics

    Lyon, MS; Andrews, SJ; Elsworth, B; Gaunt, TR; Hemani, G; Marcora, E;
    2021;  
    Genome Biology;  
    Volume: 22;  
    Issue: 1;  
  184. Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response

    Pimenova, AA; Herbinet, M; Gupta, I; Machlovi, SI; Bowles, KR; Marcora, E; Goate, AM;
    2021;  
    Neurobiology of Disease;  
    Volume: 148;  
  185. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

    Neff, RA; Wang, M; Vatansever, S; Guo, L; Ming, C; Wang, Q; Wang, E; Horgusluoglu-Moloch, E; Song, W; Li, A; Castranio, EL; Tcw, J; Ho, L; Goate, A; Fossati, V; Noggle, S; Gandy, S; Ehrlich, ME; Katsel, P; Schadt, E; Cai, D; Brennand, KJ; Haroutunian, V; Zhang, B;
    2021;  
    Science Advances;  
    Volume: 7;  
    Issue: 2;  
  186. Positive Psychosocial Factors and Cognitive Decline in Ethnically Diverse Older Adults

    Zahodne, LB; Sharifian, N; Kraal, AZ; Sol, K; Zaheed, AB; Manly, JJ; Brickman, AM;
    2021;  
    Journal of the International Neuropsychological Society: JINS;  
    Volume: 27;  
    Issue: 1;  
  187. Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome

    Andrews, SJ; Fulton-Howard, B; O'Reilly, P; Marcora, E; Goate, AM; collaborators of the Alzheimer's Disease Genetics Consortium;
    2021;  
    Annals of Neurology;  
    Volume: 89;  
    Issue: 1;  
  188. Education differentially contributes to cognitive reserve across racial/ethnic groups

    Avila, JF; Rentería, MA; Jones, RN; Vonk, JMJ; Turney, I; Sol, K; Seblova, D; Arias, F; Hill-Jarrett, T; Levy, S; Meyer, O; Racine, AM; Tom, SE; Melrose, RJ; Deters, K; Medina, LD; Carrión, CI; Díaz-Santos, M; Byrd, DR; Chesebro, A; Colon, J; Igwe, KC; Maas, B; Brickman, AM; Schupf, N; Mayeux, R; Manly, JJ;
    2021;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 17;  
    Issue: 1;  
  189. Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease

    Xue, D; Bush, WS; Renton, AE; Marcora, EA; Bis, JC; Kunkle, BW; Alzheimer's Disease Sequencing Project; Boerwinkle, E; DeStefano, AL; Farrer, L; Goate, A; Mayeux, R; Pericak-Vance, M; Schellenberg, G; Seshadri, S; Wijsman, E; Haines, JL; Blue, EE;
    2021;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 13;  
    Issue: 1;  
  190. Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

    Huq, AJ; Fulton-Howard, B; Riaz, M; Laws, S; Sebra, R; Ryan, J; Alzheimer's Disease Genetics Consortium; Renton, AE; Goate, AM; Masters, CL; Storey, E; Shah, RC; Murray, A; McNeil, J; Winship, I; James, PA; Lacaze, P;
    2021;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 13;  
    Issue: 1;  
  191. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    Kunkle, BW; Schmidt, M; Klein, H; Naj, AC; Hamilton-Nelson, KL; Larson, EB; Evans, DA; De Jager, PL; Crane, PK; Buxbaum, JD; Ertekin-Taner, N; Barnes, LL; Fallin, MD; Manly, JJ; Go, RCP; Obisesan, TO; Kamboh, MI; Bennett, DA; Hall, KS; Goate, AM; Foroud, TM; Martin, ER; Wang, L; Byrd, GS; Farrer, LA; Haines, JL; Schellenberg, GD; Mayeux, R; Pericak-Vance, MA; Reitz, C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC); Graff-Radford, NR; Martinez, I; Ayodele, T; Logue, MW; Cantwell, LB; Jean-Francois, M; Kuzma, AB; Adams, LD; Vance, JM; Cuccaro, ML; Chung, J; Mez, J; Lunetta, KL; Jun, GR; Lopez, OL; Hendrie, HC; Reiman, EM; Kowall, NW; Leverenz, JB; Small, SA; Levey, AI; Golde, TE; Saykin, AJ; Starks, TD; Albert, MS; Hyman, BT; Petersen, RC; Sano, M; Wisniewski, T; Vassar, R; Kaye, JA; Henderson, VW; DeCarli, C; LaFerla, FM; Brewer, JB; Miller, BL; Swerdlow, RH; Van Eldik, LJ; Paulson, HL; Trojanowski, JQ; Chui, HC; Rosenberg, RN; Craft, S; Grabowski, TJ; Asthana, S; Morris, JC; Strittmatter, SM; Kukull, WA;
    2021;  
    JAMA neurology;  
    Volume: 78;  
    Issue: 1;  
  192. 2021;  
    Current Alzheimer Research;  
    Volume: 18;  
    Issue: 12;  
  193. 2020

  194. Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis

    Lananna, BV; McKee, CA; King, MW; Del-Aguila, JL; Dimitry, JM; Farias, FHG; Nadarajah, CJ; Xiong, DD; Guo, C; Cammack, AJ; Elias, JA; Zhang, J; Cruchaga, C; Musiek, ES;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 574;  
  195. 2020;  
    Trends in Neurosciences;  
    Volume: 43;  
    Issue: 12;  
  196. 2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 12;  
  197. Family Ties and Aging in a Multiethnic Cohort

    Ying, G; Vonk, JMJ; Sol, K; Brickman, AM; Manly, JJ; Zahodne, LB;
    2020;  
    Journal of Aging and Health;  
    Volume: 32;  
    Issue: 10;  
  198. Sampling interstitial fluid from human skin using a microneedle patch

    Samant, PP; Niedzwiecki, MM; Raviele, N; Tran, V; Mena-Lapaix, J; Walker, DI; Felner, EI; Jones, DP; Miller, GW; Prausnitz, MR;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 571;  
  199. Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

    Ibanez, L; Bahena, JA; Yang, C; Dube, U; Farias, FHG; Budde, JP; Bergmann, K; Brenner-Webster, C; Morris, JC; Perrin, RJ; Cairns, NJ; O'Donnell, J; Álvarez, I; Diez-Fairen, M; Aguilar, M; Miller, R; Davis, AA; Pastor, P; Kotzbauer, P; Campbell, MC; Perlmutter, JS; Rhinn, H; Harari, O; Cruchaga, C; Benitez, BA;
    2020;  
    Acta Neuropathologica Communications;  
    Volume: 8;  
    Issue: 1;  
  200. Assessment of Leisure Time Physical Activity and Brain Health in a Multiethnic Cohort of Older Adults

    Gu, Y; Beato, JM; Amarante, E; Chesebro, AG; Manly, JJ; Schupf, N; Mayeux, RP; Brickman, AM;
    2020;  
    JAMA network open;  
    Volume: 3;  
    Issue: 11;  
  201. Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease

    Stamm, BC; Lao, PJ; Rizvi, B; Colon, J; Igwe, K; Chesebro, AG; Maas, B; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences;  
    Volume: 75;  
    Issue: 11;  
  202. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

    Hur, J; Frost, GR; Wu, X; Crump, C; Pan, SJ; Wong, E; Barros, M; Li, T; Nie, P; Zhai, Y; Wang, JC; Tcw, J; Guo, L; McKenzie, A; Ming, C; Zhou, X; Wang, M; Sagi, Y; Renton, AE; Esposito, BT; Kim, Y; Sadleir, KR; Trinh, I; Rissman, RA; Vassar, R; Zhang, B; Johnson, DS; Masliah, E; Greengard, P; Goate, A; Li, Y;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7831;  
  203. 2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 10;  
  204. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    Cignarella, F; Filipello, F; Bollman, B; Cantoni, C; Locca, A; Mikesell, R; Manis, M; Ibrahim, A; Deng, L; Benitez, BA; Cruchaga, C; Licastro, D; Mihindukulasuriya, K; Harari, O; Buckland, M; Holtzman, DM; Rosenthal, A; Schwabe, T; Tassi, I; Piccio, L;
    2020;  
    Acta Neuropathologica;  
    Volume: 140;  
    Issue: 4;  
  205. Negative feedback control of neuronal activity by microglia

    Badimon, A; Strasburger, HJ; Ayata, P; Chen, X; Nair, A; Ikegami, A; Hwang, P; Chan, AT; Graves, SM; Uweru, JO; Ledderose, C; Kutlu, MG; Wheeler, MA; Kahan, A; Ishikawa, M; Wang, Y; Loh, YE; Jiang, JX; Surmeier, DJ; Robson, SC; Junger, WG; Sebra, R; Calipari, ES; Kenny, PJ; Eyo, UB; Colonna, M; Quintana, FJ; Wake, H; Gradinaru, V; Schaefer, A;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7829;  
  206. Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

    Zhang, Q; Sidorenko, J; Couvy-Duchesne, B; Marioni, RE; Wright, MJ; Goate, AM; Marcora, E; Huang, K; Porter, T; Laws, SM; Australian Imaging Biomarkers and Lifestyle (AIBL) Study; Sachdev, PS; Mather, KA; Armstrong, NJ; Thalamuthu, A; Brodaty, H; Yengo, L; Yang, J; Wray, NR; McRae, AF; Visscher, PM;
    2020;  
    Nature Communications;  
    Volume: 11;  
    Issue: 1;  
  207. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    Ewers, M; Biechele, G; Suárez-Calvet, M; Sacher, C; Blume, T; Morenas-Rodriguez, E; Deming, Y; Piccio, L; Cruchaga, C; Kleinberger, G; Shaw, L; Trojanowski, JQ; Herms, J; Dichgans, M; Alzheimer's Disease Neuroimaging Initiative (ADNI); Brendel, M; Haass, C; Franzmeier, N;
    2020;  
    EMBO molecular medicine;  
    Volume: 12;  
    Issue: 9;  
  208. Genetic architecture of Alzheimer's disease

    Neuner, SM; Tcw, J; Goate, AM;
    2020;  
    Neurobiology of Disease;  
    Volume: 143;  
  209. Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

    Sherva, R; Gross, A; Mukherjee, S; Koesterer, R; Amouyel, P; Bellenguez, C; Dufouil, C; Bennett, DA; Chibnik, L; Cruchaga, C; Del-Aguila, J; Farrer, LA; Mayeux, R; Munsie, L; Winslow, A; Newhouse, S; Saykin, AJ; Kauwe, JSK; Alzheimer's Disease Genetics Consortium; Crane, PK; Green, RC;
    2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 8;  
  210. A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease

    Zhao, L; Zhang, Z; Rodriguez, SMB; Vardarajan, BN; Renton, AE; Goate, AM; Mayeux, R; Wang, GT; Leal, SM;
    2020;  
    European journal of human genetics: EJHG;  
  211. Synonymous variants associated with Alzheimer disease in multiplex families

    Tang, M; Alaniz, ME; Felsky, D; Vardarajan, B; Reyes-Dumeyer, D; Lantigua, R; Medrano, M; Bennett, DA; de Jager, PL; Mayeux, R; Santa-Maria, I; Reitz, C;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 4;  
  212. Sex-dependent autosomal effects on clinical progression of Alzheimer's disease

    Fan, CC; Banks, SJ; Thompson, WK; Chen, C; McEvoy, LK; Tan, CH; Kukull, W; Bennett, DA; Farrer, LA; Mayeux, R; Schellenberg, GD; Andreassen, OA; Desikan, R; Dale, AM;
    2020;  
    Brain: A Journal of Neurology;  
    Volume: 143;  
    Issue: 7;  
  213. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

    Castillo-Barnes, D; Su, L; Ramírez, J; Salas-Gonzalez, D; Martinez-Murcia, FJ; Illan, IA; Segovia, F; Ortiz, A; Cruchaga, C; Farlow, MR; Xiong, C; Graff-Radford, NR; Schofield, PR; Masters, CL; Salloway, S; Jucker, M; Mori, H; Levin, J; Gorriz, JM; Dominantly Inherited Alzheimer Network (DIAN);
    2020;  
    An International Journal on Information Fusion;  
    Volume: 58;  
  214. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Johnson, ECB; Dammer, EB; Duong, DM; Ping, L; Zhou, M; Yin, L; Higginbotham, LA; Guajardo, A; White, B; Troncoso, JC; Thambisetty, M; Montine, TJ; Lee, EB; Trojanowski, JQ; Beach, TG; Reiman, EM; Haroutunian, V; Wang, M; Schadt, E; Zhang, B; Dickson, DW; Ertekin-Taner, N; Golde, TE; Petyuk, VA; De Jager, PL; Bennett, DA; Wingo, TS; Rangaraju, S; Hajjar, I; Shulman, JM; Lah, JJ; Levey, AI; Seyfried, NT;
    2020;  
    Nature Medicine;  
    Volume: 26;  
    Issue: 5;  
  215. Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease

    Bussies, PL; Rajabli, F; Griswold, A; Dorfsman, DA; Whitehead, P; Adams, LD; Mena, PR; Cuccaro, M; Haines, JL; Byrd, GS; Beecham, GW; Pericak-Vance, MA; Young, JI; Vance, JM;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 2;  
  216. 2020;  
    The Lancet. Neurology;  
    Volume: 19;  
    Issue: 4;  
  217. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs

    Ramdhani, S; Navarro, E; Udine, E; Efthymiou, AG; Schilder, BM; Parks, M; Goate, A; Raj, T;
    2020;  
    PLOS Genetics;  
    Volume: 16;  
    Issue: 2;  
  218. Overlapping genetic architecture between Parkinson disease and melanoma

    Dube, U; Ibanez, L; Budde, JP; Benitez, BA; Davis, AA; Harari, O; Iles, MM; Law, MH; Brown, KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
    Issue: 2;  
  219. 2020;  
    Current Opinion in Immunology;  
    Volume: 62;  
  220. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

    Li, Z; Farias, FHG; Dube, U; Del-Aguila, JL; Mihindukulasuriya, KA; Fernandez, MV; Ibanez, L; Budde, JP; Wang, F; Lake, AM; Deming, Y; Perez, J; Yang, C; Bahena, JA; Qin, W; Bradley, JL; Davenport, R; Bergmann, K; Morris, JC; Perrin, RJ; Benitez, BA; Dougherty, JD; Harari, O; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
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  221. Linking depressive symptoms and cognitive functioning: The mediating role of leisure activity

    Sharifian, N; Gu, Y; Manly, JJ; Schupf, N; Mayeux, R; Brickman, AM; Zahodne, LB;
    2020;  
    Neuropsychology;  
    Volume: 34;  
    Issue: 1;  
  222. Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity

    Vardarajan, B; Kalia, V; Manly, J; Brickman, A; Reyes-Dumeyer, D; Lantigua, R; Ionita-Laza, I; Jones, DP; Miller, GW; Mayeux, R;
    2020;  
    Alzheimer's & Dementia (New York, N. Y.);  
    Volume: 6;  
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  223. APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults

    Turney, IC; Chesebro, AG; Rentería, MA; Lao, PJ; Beato, JM; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 12;  
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  224. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

    Faura, J; Bustamante, A; Penalba, A; Giralt, D; Simats, A; Martínez-Sáez, E; Alcolea, D; Fortea, J; Lleó, A; Teunissen, CE; van der Flier, WM; Ibañez, L; Harari, O; Cruchaga, C; Hernández-Guillamón, M; Delgado, P; Montaner, J;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 73;  
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  225. Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning

    Stojanovic, M; Jin, Y; Fagan, AM; Benzinger, TL; Hassenstab, J; Cruchaga, C; Morris, JC; Head, D;
    2020;  
    Alzheimer Disease and Associated Disorders;  
    Volume: 34;  
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  226. Reproducibility of serum cytokines in an elderly population

    Guo, J; Schupf, N; Mayeux, RP; Gu, Y;
    2020;  
    Immunity & Ageing: I & A;  
    Volume: 17;  
  227. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes

    Olive, C; Ibanez, L; Farias, FHG; Wang, F; Budde, JP; Norton, JB; Gentsch, J; Morris, JC; Li, Z; Dube, U; Del-Aguila, J; Bergmann, K; Bradley, J; Benitez, BA; Harari, O; Fagan, A; Ances, B; Cruchaga, C; Fernandez, MV;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 77;  
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  228. Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease

    Aschenbrenner, AJ; Gordon, BA; Fagan, AM; Schindler, SE; Balota, DA; Morris, JC; Hassenstab, JJ;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 74;  
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  229. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

    Lancour, D; Dupuis, J; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GC; Crovella, M; Farrer, LA; Kasif, S;
    2020;  
    Alzheimer's Research & Therapy;  
    Volume: 12;  
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  230. APOE genotype regulates pathology and disease progression in synucleinopathy

    Davis, AA; Inman, CE; Wargel, ZM; Dube, U; Freeberg, BM; Galluppi, A; Haines, JN; Dhavale, DD; Miller, R; Choudhury, FA; Sullivan, PM; Cruchaga, C; Perlmutter, JS; Ulrich, JD; Benitez, BA; Kotzbauer, PT; Holtzman, DM;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
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  231. 2019

  232. Sex differences in the genetic predictors of Alzheimer's pathology

    Dumitrescu, L; Barnes, LL; Thambisetty, M; Beecham, G; Kunkle, B; Bush, WS; Gifford, KA; Chibnik, LB; Mukherjee, S; De Jager, PL; Kukull, W; Crane, PK; Resnick, SM; Keene, CD; Montine, TJ; Schellenberg, GD; Deming, Y; Chao, MJ; Huentelman, M; Martin, ER; Hamilton-Nelson, K; Shaw, LM; Trojanowski, JQ; Peskind, ER; Cruchaga, C; Pericak-Vance, MA; Goate, AM; Cox, NJ; Haines, JL; Zetterberg, H; Blennow, K; Larson, EB; Johnson, SC; Albert, M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative; Bennett, DA; Schneider, JA; Jefferson, AL; Hohman, TJ;
    2019;  
    Brain: A Journal of Neurology;  
    Volume: 142;  
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  233. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

    Ewers, M; Franzmeier, N; Suárez-Calvet, M; Morenas-Rodriguez, E; Caballero, MAA; Kleinberger, G; Piccio, L; Cruchaga, C; Deming, Y; Dichgans, M; Trojanowski, JQ; Shaw, LM; Weiner, MW; Haass, C; Alzheimer’s Disease Neuroimaging Initiative;
    2019;  
    Science Translational Medicine;  
    Volume: 11;  
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  234. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

    Deming, Y; Filipello, F; Cignarella, F; Cantoni, C; Hsu, S; Mikesell, R; Li, Z; Del-Aguila, JL; Dube, U; Farias, FG; Bradley, J; Budde, J; Ibanez, L; Fernandez, MV; Blennow, K; Zetterberg, H; Heslegrave, A; Johansson, PM; Svensson, J; Nellgård, B; Lleo, A; Alcolea, D; Clarimon, J; Rami, L; Molinuevo, JL; Suárez-Calvet, M; Morenas-Rodríguez, E; Kleinberger, G; Ewers, M; Harari, O; Haass, C; Brett, TJ; Benitez, BA; Karch, CM; Piccio, L; Cruchaga, C;
    2019;  
    Science Translational Medicine;  
    Volume: 11;  
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  235. TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

    Del-Aguila, JL; Benitez, BA; Li, Z; Dube, U; Mihindukulasuriya, KA; Budde, JP; Farias, FHG; Fernández, MV; Ibanez, L; Jiang, S; Perrin, RJ; Cairns, NJ; Morris, JC; Harari, O; Cruchaga, C;
    2019;  
    Molecular Neurodegeneration;  
    Volume: 14;  
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  236. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

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    2019;  
    Nature Genetics;  
    Volume: 51;  
    Issue: 3;  
  237. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

    Kapoor, M; Wang, J; Farris, SP; Liu, Y; McClintick, J; Gupta, I; Meyers, JL; Bertelsen, S; Chao, M; Nurnberger, J; Tischfield, J; Harari, O; Zeran, L; Hesselbrock, V; Bauer, L; Raj, T; Porjesz, B; Agrawal, A; Foroud, T; Edenberg, HJ; Mayfield, RD; Goate, A;
    2019;  
    Translational Psychiatry;  
    Volume: 9;  
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  238. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

    Suárez-Calvet, M; Morenas-Rodríguez, E; Kleinberger, G; Schlepckow, K; Araque Caballero, MÁ; Franzmeier, N; Capell, A; Fellerer, K; Nuscher, B; Eren, E; Levin, J; Deming, Y; Piccio, L; Karch, CM; Cruchaga, C; Shaw, LM; Trojanowski, JQ; Weiner, M; Ewers, M; Haass, C; Alzheimer’s Disease Neuroimaging Initiative;
    2019;  
    Molecular Neurodegeneration;  
    Volume: 14;  
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  239. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

    Dube, U; Del-Aguila, JL; Li, Z; Budde, JP; Jiang, S; Hsu, S; Ibanez, L; Fernandez, MV; Farias, F; Norton, J; Gentsch, J; Wang, F; Dominantly Inherited Alzheimer Network (DIAN); Salloway, S; Masters, CL; Lee, J; Graff-Radford, NR; Chhatwal, JP; Bateman, RJ; Morris, JC; Karch, CM; Harari, O; Cruchaga, C;
    2019;  
    Nature Neuroscience;  
    Volume: 22;  
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  240. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease

    Ma, Y; Jun, GR; Chung, J; Zhang, X; Kunkle, BW; Naj, AC; White, CC; Bennett, DA; De Jager, PL; Alzheimer’s Disease Genetics Consortium; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GD; Farrer, LA; Lunetta, KL;
    2019;  
    Aging Cell;  
    Volume: 18;  
    Issue: 4;  
  241. A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

    Del-Aguila, JL; Li, Z; Dube, U; Mihindukulasuriya, KA; Budde, JP; Fernandez, MV; Ibanez, L; Bradley, J; Wang, F; Bergmann, K; Davenport, R; Morris, JC; Holtzman, DM; Perrin, RJ; Benitez, BA; Dougherty, J; Cruchaga, C; Harari, O;
    2019;  
    Alzheimer's Research & Therapy;  
    Volume: 11;  
    Issue: 1;  
  242. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

    Zhang, X; Zhu, C; Beecham, G; Vardarajan, BN; Ma, Y; Lancour, D; Farrell, JJ; Chung, J; Alzheimer's Disease Sequencing Project; Mayeux, R; Haines, JL; Schellenberg, GD; Pericak-Vance, MA; Lunetta, KL; Farrer, LA;
    2019;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 15;  
    Issue: 3;  
  243. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease

    Baker, E; Sims, R; Leonenko, G; Frizzati, A; Harwood, JC; Grozeva, D; GERAD/PERADES; CHARGE; ADGC; EADI; IGAP consortia; Morgan, K; Passmore, P; Holmes, C; Powell, J; Brayne, C; Gill, M; Mead, S; Bossù, P; Spalletta, G; Goate, AM; Cruchaga, C; Maier, W; Heun, R; Jessen, F; Peters, O; Dichgans, M; FröLich, L; Ramirez, A; Jones, L; Hardy, J; Ivanov, D; Hill, M; Holmans, P; Allen, ND; Morgan, BP; Seshadri, S; Schellenberg, GD; Amouyel, P; Williams, J; Escott-Price, V;
    2019;  
    PloS One;  
    Volume: 14;  
    Issue: 7;  
  244. 2018

  245. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

    Jiang, S; Wen, N; Li, Z; Dube, U; Del Aguila, J; Budde, J; Martinez, R; Hsu, S; Fernandez, MV; Cairns, NJ; Dominantly Inherited Alzheimer Network (DIAN); International FTD-Genomics Consortium (IFGC); Harari, O; Cruchaga, C; Karch, CM;
    2018;  
    Translational Psychiatry;  
    Volume: 8;  
    Issue: 1;  
  246. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease

    Beecham, GW; Vardarajan, B; Blue, E; Bush, W; Jaworski, J; Barral, S; DeStefano, A; Hamilton-Nelson, K; Kunkle, B; Martin, ER; Naj, A; Rajabli, F; Reitz, C; Thornton, T; van Duijn, C; Goate, A; Seshadri, S; Farrer, LA; Boerwinkle, E; Schellenberg, G; Haines, JL; Wijsman, E; Mayeux, R; Pericak-Vance, MA; Alzheimer's Disease Sequencing Project;
    2018;  
    Neurology. Genetics;  
    Volume: 4;  
    Issue: 6;  
  247. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

    Suárez-Calvet, M; Capell, A; Araque Caballero, MÁ; Morenas-Rodríguez, E; Fellerer, K; Franzmeier, N; Kleinberger, G; Eren, E; Deming, Y; Piccio, L; Karch, CM; Cruchaga, C; Paumier, K; Bateman, RJ; Fagan, AM; Morris, JC; Levin, J; Danek, A; Jucker, M; Masters, CL; Rossor, MN; Ringman, JM; Shaw, LM; Trojanowski, JQ; Weiner, M; Ewers, M; Haass, C; Dominantly Inherited Alzheimer Network; Alzheimer's Disease Neuroimaging Initiative;
    2018;  
    EMBO molecular medicine;  
    Volume: 10;  
    Issue: 12;  
  248. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

    Rathore, N; Ramani, SR; Pantua, H; Payandeh, J; Bhangale, T; Wuster, A; Kapoor, M; Sun, Y; Kapadia, SB; Gonzalez, L; Zarrin, AA; Goate, A; Hansen, DV; Behrens, TW; Graham, RR;
    2018;  
    PLoS genetics;  
    Volume: 14;  
    Issue: 11;  
  249. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

    Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; Cantwell, L; Charbonnier, C; Chung, J; Crane, PK; Cruchaga, C; Cupples, LA; Dartigues, J; Debette, S; Deleuze, J; Fulton, L; Gabriel, SB; Genin, E; Gibbs, RA; Goate, A; Grenier-Boley, B; Gupta, N; Haines, JL; Havulinna, AS; Helisalmi, S; Hiltunen, M; Howrigan, DP; Ikram, MA; Kaprio, J; Konrad, J; Kuzma, A; Lander, ES; Lathrop, M; Lehtimäki, T; Lin, H; Mattila, K; Mayeux, R; Muzny, DM; Nasser, W; Neale, B; Nho, K; Nicolas, G; Patel, D; Pericak-Vance, MA; Perola, M; Psaty, BM; Quenez, O; Rajabli, F; Redon, R; Reitz, C; Remes, AM; Salomaa, V; Sarnowski, C; Schmidt, H; Schmidt, M; Schmidt, R; Soininen, H; Thornton, TA; Tosto, G; Tzourio, C; van der Lee, SJ; van Duijn, CM; Valladares, O; Vardarajan, B; Wang, L; Wang, W; Wijsman, E; Wilson, RK; Witten, D; Worley, KC; Zhang, X; Alzheimer’s Disease Sequencing Project; Bellenguez, C; Lambert, J; Kurki, MI; Palotie, A; Daly, M; Boerwinkle, E; Lunetta, KL; Destefano, AL; Dupuis, J; Martin, ER; Schellenberg, GD; Seshadri, S; Naj, AC; Fornage, M; Farrer, LA;
    2018;  
    Molecular Psychiatry;  
  250. 2018;  
    Expert Opinion on Therapeutic Targets;  
    Volume: 22;  
    Issue: 7;