FunGen-AD researcher Oscar Harari was part of a team that found a new way to improve waste clearance from the brain that could help treat or prevent neurodegenerative conditions. Immune cells surrounding the brain that influence how efficiently waste is swept out of the brain are impaired in old mice and in people and mice with Alzheimer’s disease.
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New biomarker of early-stage Alzheimer’s disease identified in study supported by FunGen-AD
FunGen-AD investigator Carlos Cruchaga was part of a team that identified a unique biomarker that could lead to new diagnostic tests able to detect Alzheimer’s disease before symptoms appear. Levels of this protein in cerebrospinal fluid can reliably detect damage to the cells lining tiny blood vessels in the brain in Alzheimer’s disease. Blood vessel injury is an important contributor to cognitive impairment in even the earliest presymptomatic stages of the disease.
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