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    2020

  1. Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis

    Lananna, BV; McKee, CA; King, MW; Del-Aguila, JL; Dimitry, JM; Farias, FHG; Nadarajah, CJ; Xiong, DD; Guo, C; Cammack, AJ; Elias, JA; Zhang, J; Cruchaga, C; Musiek, ES;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 574;  
  2. 2020;  
    Trends in Neurosciences;  
    Volume: 43;  
    Issue: 12;  
  3. 2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 12;  
  4. Family Ties and Aging in a Multiethnic Cohort

    Ying, G; Vonk, JMJ; Sol, K; Brickman, AM; Manly, JJ; Zahodne, LB;
    2020;  
    Journal of Aging and Health;  
    Volume: 32;  
    Issue: 10;  
  5. Sampling interstitial fluid from human skin using a microneedle patch

    Samant, PP; Niedzwiecki, MM; Raviele, N; Tran, V; Mena-Lapaix, J; Walker, DI; Felner, EI; Jones, DP; Miller, GW; Prausnitz, MR;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 571;  
  6. Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

    Ibanez, L; Bahena, JA; Yang, C; Dube, U; Farias, FHG; Budde, JP; Bergmann, K; Brenner-Webster, C; Morris, JC; Perrin, RJ; Cairns, NJ; O'Donnell, J; Álvarez, I; Diez-Fairen, M; Aguilar, M; Miller, R; Davis, AA; Pastor, P; Kotzbauer, P; Campbell, MC; Perlmutter, JS; Rhinn, H; Harari, O; Cruchaga, C; Benitez, BA;
    2020;  
    Acta Neuropathologica Communications;  
    Volume: 8;  
    Issue: 1;  
  7. Assessment of Leisure Time Physical Activity and Brain Health in a Multiethnic Cohort of Older Adults

    Gu, Y; Beato, JM; Amarante, E; Chesebro, AG; Manly, JJ; Schupf, N; Mayeux, RP; Brickman, AM;
    2020;  
    JAMA network open;  
    Volume: 3;  
    Issue: 11;  
  8. Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease

    Stamm, BC; Lao, PJ; Rizvi, B; Colon, J; Igwe, K; Chesebro, AG; Maas, B; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences;  
    Volume: 75;  
    Issue: 11;  
  9. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

    Hur, J; Frost, GR; Wu, X; Crump, C; Pan, SJ; Wong, E; Barros, M; Li, T; Nie, P; Zhai, Y; Wang, JC; Tcw, J; Guo, L; McKenzie, A; Ming, C; Zhou, X; Wang, M; Sagi, Y; Renton, AE; Esposito, BT; Kim, Y; Sadleir, KR; Trinh, I; Rissman, RA; Vassar, R; Zhang, B; Johnson, DS; Masliah, E; Greengard, P; Goate, A; Li, Y;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7831;  
  10. 2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 10;  
  11. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    Cignarella, F; Filipello, F; Bollman, B; Cantoni, C; Locca, A; Mikesell, R; Manis, M; Ibrahim, A; Deng, L; Benitez, BA; Cruchaga, C; Licastro, D; Mihindukulasuriya, K; Harari, O; Buckland, M; Holtzman, DM; Rosenthal, A; Schwabe, T; Tassi, I; Piccio, L;
    2020;  
    Acta Neuropathologica;  
    Volume: 140;  
    Issue: 4;  
  12. Negative feedback control of neuronal activity by microglia

    Badimon, A; Strasburger, HJ; Ayata, P; Chen, X; Nair, A; Ikegami, A; Hwang, P; Chan, AT; Graves, SM; Uweru, JO; Ledderose, C; Kutlu, MG; Wheeler, MA; Kahan, A; Ishikawa, M; Wang, Y; Loh, YE; Jiang, JX; Surmeier, DJ; Robson, SC; Junger, WG; Sebra, R; Calipari, ES; Kenny, PJ; Eyo, UB; Colonna, M; Quintana, FJ; Wake, H; Gradinaru, V; Schaefer, A;
    2020;  
    Nature;  
    Volume: 586;  
    Issue: 7829;  
  13. Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

    Zhang, Q; Sidorenko, J; Couvy-Duchesne, B; Marioni, RE; Wright, MJ; Goate, AM; Marcora, E; Huang, K; Porter, T; Laws, SM; Australian Imaging Biomarkers and Lifestyle (AIBL) Study; Sachdev, PS; Mather, KA; Armstrong, NJ; Thalamuthu, A; Brodaty, H; Yengo, L; Yang, J; Wray, NR; McRae, AF; Visscher, PM;
    2020;  
    Nature Communications;  
    Volume: 11;  
    Issue: 1;  
  14. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    Ewers, M; Biechele, G; Suárez-Calvet, M; Sacher, C; Blume, T; Morenas-Rodriguez, E; Deming, Y; Piccio, L; Cruchaga, C; Kleinberger, G; Shaw, L; Trojanowski, JQ; Herms, J; Dichgans, M; Alzheimer's Disease Neuroimaging Initiative (ADNI); Brendel, M; Haass, C; Franzmeier, N;
    2020;  
    EMBO molecular medicine;  
    Volume: 12;  
    Issue: 9;  
  15. Genetic architecture of Alzheimer's disease

    Neuner, SM; Tcw, J; Goate, AM;
    2020;  
    Neurobiology of Disease;  
    Volume: 143;  
  16. Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

    Sherva, R; Gross, A; Mukherjee, S; Koesterer, R; Amouyel, P; Bellenguez, C; Dufouil, C; Bennett, DA; Chibnik, L; Cruchaga, C; Del-Aguila, J; Farrer, LA; Mayeux, R; Munsie, L; Winslow, A; Newhouse, S; Saykin, AJ; Kauwe, JSK; Alzheimer's Disease Genetics Consortium; Crane, PK; Green, RC;
    2020;  
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association;  
    Volume: 16;  
    Issue: 8;  
  17. Synonymous variants associated with Alzheimer disease in multiplex families

    Tang, M; Alaniz, ME; Felsky, D; Vardarajan, B; Reyes-Dumeyer, D; Lantigua, R; Medrano, M; Bennett, DA; de Jager, PL; Mayeux, R; Santa-Maria, I; Reitz, C;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 4;  
  18. A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease

    Zhao, L; Zhang, Z; Rodriguez, SMB; Vardarajan, BN; Renton, AE; Goate, AM; Mayeux, R; Wang, GT; Leal, SM;
    2020;  
    European journal of human genetics: EJHG;  
  19. Sex-dependent autosomal effects on clinical progression of Alzheimer's disease

    Fan, CC; Banks, SJ; Thompson, WK; Chen, C; McEvoy, LK; Tan, CH; Kukull, W; Bennett, DA; Farrer, LA; Mayeux, R; Schellenberg, GD; Andreassen, OA; Desikan, R; Dale, AM;
    2020;  
    Brain: A Journal of Neurology;  
    Volume: 143;  
    Issue: 7;  
  20. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

    Castillo-Barnes, D; Su, L; Ramírez, J; Salas-Gonzalez, D; Martinez-Murcia, FJ; Illan, IA; Segovia, F; Ortiz, A; Cruchaga, C; Farlow, MR; Xiong, C; Graff-Radford, NR; Schofield, PR; Masters, CL; Salloway, S; Jucker, M; Mori, H; Levin, J; Gorriz, JM; Dominantly Inherited Alzheimer Network (DIAN);
    2020;  
    An International Journal on Information Fusion;  
    Volume: 58;  
  21. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Johnson, ECB; Dammer, EB; Duong, DM; Ping, L; Zhou, M; Yin, L; Higginbotham, LA; Guajardo, A; White, B; Troncoso, JC; Thambisetty, M; Montine, TJ; Lee, EB; Trojanowski, JQ; Beach, TG; Reiman, EM; Haroutunian, V; Wang, M; Schadt, E; Zhang, B; Dickson, DW; Ertekin-Taner, N; Golde, TE; Petyuk, VA; De Jager, PL; Bennett, DA; Wingo, TS; Rangaraju, S; Hajjar, I; Shulman, JM; Lah, JJ; Levey, AI; Seyfried, NT;
    2020;  
    Nature Medicine;  
    Volume: 26;  
    Issue: 5;  
  22. 2020;  
    The Lancet. Neurology;  
    Volume: 19;  
    Issue: 4;  
  23. Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease

    Bussies, PL; Rajabli, F; Griswold, A; Dorfsman, DA; Whitehead, P; Adams, LD; Mena, PR; Cuccaro, M; Haines, JL; Byrd, GS; Beecham, GW; Pericak-Vance, MA; Young, JI; Vance, JM;
    2020;  
    Neurology. Genetics;  
    Volume: 6;  
    Issue: 2;  
  24. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs

    Ramdhani, S; Navarro, E; Udine, E; Efthymiou, AG; Schilder, BM; Parks, M; Goate, A; Raj, T;
    2020;  
    PLOS Genetics;  
    Volume: 16;  
    Issue: 2;  
  25. 2020;  
    Current Opinion in Immunology;  
    Volume: 62;  
  26. Overlapping genetic architecture between Parkinson disease and melanoma

    Dube, U; Ibanez, L; Budde, JP; Benitez, BA; Davis, AA; Harari, O; Iles, MM; Law, MH; Brown, KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
    Issue: 2;  
  27. Linking depressive symptoms and cognitive functioning: The mediating role of leisure activity

    Sharifian, N; Gu, Y; Manly, JJ; Schupf, N; Mayeux, R; Brickman, AM; Zahodne, LB;
    2020;  
    Neuropsychology;  
    Volume: 34;  
    Issue: 1;  
  28. Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity

    Vardarajan, B; Kalia, V; Manly, J; Brickman, A; Reyes-Dumeyer, D; Lantigua, R; Ionita-Laza, I; Jones, DP; Miller, GW; Mayeux, R;
    2020;  
    Alzheimer's & Dementia (New York, N. Y.);  
    Volume: 6;  
    Issue: 1;  
  29. APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults

    Turney, IC; Chesebro, AG; Rentería, MA; Lao, PJ; Beato, JM; Schupf, N; Mayeux, R; Manly, JJ; Brickman, AM;
    2020;  
    Alzheimer's & Dementia (Amsterdam, Netherlands);  
    Volume: 12;  
    Issue: 1;  
  30. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

    Faura, J; Bustamante, A; Penalba, A; Giralt, D; Simats, A; Martínez-Sáez, E; Alcolea, D; Fortea, J; Lleó, A; Teunissen, CE; van der Flier, WM; Ibañez, L; Harari, O; Cruchaga, C; Hernández-Guillamón, M; Delgado, P; Montaner, J;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 73;  
    Issue: 4;  
  31. Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning

    Stojanovic, M; Jin, Y; Fagan, AM; Benzinger, TL; Hassenstab, J; Cruchaga, C; Morris, JC; Head, D;
    2020;  
    Alzheimer Disease and Associated Disorders;  
    Volume: 34;  
    Issue: 3;  
  32. Reproducibility of serum cytokines in an elderly population

    Guo, J; Schupf, N; Mayeux, RP; Gu, Y;
    2020;  
    Immunity & Ageing: I & A;  
    Volume: 17;  
  33. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes

    Olive, C; Ibanez, L; Farias, FHG; Wang, F; Budde, JP; Norton, JB; Gentsch, J; Morris, JC; Li, Z; Dube, U; Del-Aguila, J; Bergmann, K; Bradley, J; Benitez, BA; Harari, O; Fagan, A; Ances, B; Cruchaga, C; Fernandez, MV;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 77;  
    Issue: 4;  
  34. Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease

    Aschenbrenner, AJ; Gordon, BA; Fagan, AM; Schindler, SE; Balota, DA; Morris, JC; Hassenstab, JJ;
    2020;  
    Journal of Alzheimer's disease: JAD;  
    Volume: 74;  
    Issue: 4;  
  35. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

    Li, Z; Farias, FHG; Dube, U; Del-Aguila, JL; Mihindukulasuriya, KA; Fernandez, MV; Ibanez, L; Budde, JP; Wang, F; Lake, AM; Deming, Y; Perez, J; Yang, C; Bahena, JA; Qin, W; Bradley, JL; Davenport, R; Bergmann, K; Morris, JC; Perrin, RJ; Benitez, BA; Dougherty, JD; Harari, O; Cruchaga, C;
    2020;  
    Acta Neuropathologica;  
    Volume: 139;  
    Issue: 1;  
  36. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

    Lancour, D; Dupuis, J; Mayeux, R; Haines, JL; Pericak-Vance, MA; Schellenberg, GC; Crovella, M; Farrer, LA; Kasif, S;
    2020;  
    Alzheimer's Research & Therapy;  
    Volume: 12;  
    Issue: 1;  
  37. APOE genotype regulates pathology and disease progression in synucleinopathy

    Davis, AA; Inman, CE; Wargel, ZM; Dube, U; Freeberg, BM; Galluppi, A; Haines, JN; Dhavale, DD; Miller, R; Choudhury, FA; Sullivan, PM; Cruchaga, C; Perlmutter, JS; Ulrich, JD; Benitez, BA; Kotzbauer, PT; Holtzman, DM;
    2020;  
    Science Translational Medicine;  
    Volume: 12;  
    Issue: 529;