ROSMAP DLPFC protein expression QTL

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) DLPFC protein expression.

Please refer to this document for an overview of the ROSMAP project.

Contact

Study Overview

  • Study name : ROSMAP Glyco_proteomics QTL
  • Study Description : Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) proteomics QTL analysis summary statistics using the FGC xQTL pipeline.

Samples’ phenotype information (sex, age, race etc.) can be found in ROSMAP metadata, see “Other information” section in this document

Analysis Status

TransQTL association:

See notebooks in:

The notebooks in this folder contain the commands and data wrangling codes for analysis of the methylation data in KnightADRC. (data wrangling exist because not all data are processed using the xqtl-pipeline from the beginning and need to be reformatted to fit one intermediate step of the pipeline).

Association data preprocessing

Genotype data preprocessing

Principal component analysis for eQTL mapping

Phenotype data preprocessing

Covariate data preprocessing

Association scan using TensorQTL and summary statistics standardization

  • TensorQTL.ipynb provides the pipeline to generate TensorQTL cis association results for all QTLs.
  • ROSMAP_gpQTL provides information about the input files for adjusted/unadjusted glycoproteomics TensorQTL cis association in the base_params variable in [generate_command_1].

Path(s) to cis-QTL association testing

output of TensorQTL.ipynb

  • s3://statfungen/ftp_fgc_xqtl/analysis_result/cis_association/ROSMAP/pQTL/gpQTL/

Path(s) to fine-mapping with SuSiE RSS model

Fine-mapping model objects (SuSiE-RSS, .rds) are available in the finemapping models folder (syn69670592).

Path(s) to TWAS models

Pre-trained TWAS weight models for this context: syn69670600

Quantile TWAS (qTWAS) models: syn69670611

Path(s) to colocalization with SuSiE-coloc / ColocBoost

Multi-context colocalization models (ColocBoost): syn69670597

AD GWAS–xQTL colocalization results: syn69865816

AD GWAS–xQTL colocalization models: syn69670630