FunGen-xQTL Resources

ROSMAP RNA-seq microglia gene expression QTL

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) microglia data-set.

Please refer to this document for an overview of the ROSMAP project.

Cohort
ROSMAPReligious Orders Study and Rush Memory and Aging Project
Modality
eQTLQTL results
Tissue or cell type
microglia
Sample size
Not recorded on this page
Release status
Stagednot yet verified
Access
ControlledData use certificate
Lead analysts
Travyse EdwardsSelect a name to email them
Source data
ROSMAP microglia Expression
Open syn2580853 in Synapse ↗ Query associations in the xQTL Atlas ↗

Access

Controlled access. Request data access for ROSMAP on the AD Knowledge Portal; you need a Synapse account. See How to get the data.

WhereIDAccessWhat you get
Synapsesyn2580853ControlledResults described below

Other Synapse IDs on this page syn11468526 syn69670592 syn69670600 syn69670611 syn69670597 syn69865816 syn69670630

shell
pip install synapseclient
synapse login
synapse get -r syn2580853

Contact

Travyse Edwards

Data descriptions

The ROSMAP monocyte data were downloaded from syn2580853 on Janunary xx, 2023.

  • Path on CU cluster /..

I didn’t do cis assocaition for microglia seperately?

Path(s) to fine-mapping with SuSiE RSS model

Fine-mapping model objects (SuSiE-RSS, .rds) are available in the finemapping models folder (syn69670592).

Path(s) to TWAS models

Pre-trained TWAS weight models for this context: syn69670600

Quantile TWAS (qTWAS) models: syn69670611

Path(s) to colocalization with SuSiE-coloc / ColocBoost

Multi-context colocalization models (ColocBoost): syn69670597

AD GWAS–xQTL colocalization results: syn69865816

AD GWAS–xQTL colocalization models: syn69670630