ROSMAP DLPFC Metabolomics
Access
Controlled access. Request data access for ROSMAP on the AD Knowledge Portal; you need a Synapse account. See How to get the data.
| Where | ID | Access | What you get |
|---|---|---|---|
| Synapse | syn69670592 | Controlled | Files described below |
Other Synapse IDs on this page syn69670597 syn69670630 syn69865816
pip install synapseclient
synapse login
synapse get -r syn69670592Summary
Brain metabolomics data from the Religious Orders Study and Memory and Aging Project (ROSMAP), profiling ~600 metabolites in dorsolateral prefrontal cortex (DLPFC) samples.
Dataset Information
- Cohort: ROSMAP (Religious Orders Study / Memory and Aging Project)
- Brain region: Dorsolateral prefrontal cortex (DLPFC)
- Data type: Untargeted metabolomics
- Metabolites: ~600 metabolites
- Platform: Mass spectrometry
Omics Data
Metabolite abundance matrices
Metabolite abundance data available through the AD Knowledge Portal.
QTL Analysis
QTL analysis for this dataset is documented in ../../qtl/metQTL/ROSMAP_DLPFC_metabolomics_qtl.md.
Flagship paper analyses:
- Fine-mapping (SuSiE-RSS): syn69670592
- Pairwise colocalization (SuSiE-coloc): syn69670597
- AD GWAS–xQTL colocalization results: syn69865816
- AD GWAS–xQTL colocalization models: syn69670630