FunGen-xQTL Resources

ROSMAP DLPFC Glycoproteomics

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) DLPFC glycoproteomics (N-glycosylation proteomics).

Please refer to this document for an overview of the ROSMAP project.

Cohort
ROSMAPReligious Orders Study and Rush Memory and Aging Project
Data type
GlycoproteomicsOmics data
Tissue or cell type
DLPFC
Sample size
Not recorded on this page
Release status
Stagednot yet verified
Access
ControlledData use certificate
Lead analysts
FunGen-xQTL Analysis Working GroupContact by name
QTL results
ROSMAP DLPFC glycoQTL
Open syn17015098 in Synapse ↗

Access

Controlled access. Request data access for ROSMAP on the AD Knowledge Portal; you need a Synapse account. See How to get the data.

WhereIDAccessWhat you get
Synapsesyn17015098ControlledFiles described below

Other Synapse IDs on this page syn69670592 syn69670597 syn69670600 syn69670611 syn69670630 syn69865816

shell
pip install synapseclient
synapse login
synapse get -r syn17015098

Contact

FunGen-xQTL Analysis Working Group

Study Overview

  • PI: David A. Bennett (Rush University Medical Center, Chicago, IL, USA)
  • Grant numbers: U01AG046152, R01AG048015, U01AG061356, R01AG15819, U01AG061359
  • Publication: PMID: 30084846
  • Genetics publication: PMID: 40407102
  • Acknowledgement: Study data were generated from postmortem brain tissue provided by the Religious Orders Study and Rush Memory and Aging Project (ROSMAP) cohort at Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago.
  • Omics data: syn17015098
  • Genetics data: ng00067
  • Disease: Alzheimer’s Disease

Dataset Details

Overview

Glycoproteomics data profiling N-glycosylation of proteins from dorsolateral prefrontal cortex (DLPFC) tissue of ROSMAP participants. Protein glycosylation is quantified alongside standard protein abundance to characterize post-translational modifications relevant to Alzheimer’s disease pathology.

  • Brain region: Dorsolateral prefrontal cortex (DLPFC)
  • Data type: Glycoproteomics (N-glycosylation mass spectrometry)
  • Platform: Tandem mass tag (TMT) isobaric labeling mass spectrometry

Molecular Phenotype Matrices

Glycopeptide abundance matrices normalized from TMT-based mass spectrometry data. Available through the AD Knowledge Portal at syn17015098.

QTL Analysis

QTL analysis for this dataset is documented in ../../qtl/glycoQTL/ROSMAP_DLPFC_glycoproteomics_qtl.md.

Flagship paper analyses: